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Exportin
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<StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'> | <StructureSection load='3icq' size='400' side='right' caption='Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code [[3icq]]).' scene='59/592125/Cv/9'> | ||
| - | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | + | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. <br /> |
| + | *'''XPO-1''' mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA.<br /> | ||
| + | *'''XPO-4''' mediates nuclear transport of eukaryotic translation initiation factor 5A<ref>PMID:10944119</ref>.<br /> | ||
| + | *'''XPO-4''' mediates nuclear transport of pre-miroRNAs and short hairpin RNAs<ref>PMID:14681208</ref>.<br /> | ||
| + | *'''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>.<br /> | ||
==Structural highlights == | ==Structural highlights == | ||
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<scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref> | <scene name='59/592125/Cv/12'>Mg coordination site</scene> (PDB code [[3icq]]).<ref>PMID:19680239</ref> | ||
| - | </StructureSection> | ||
==3D structures of exportin== | ==3D structures of exportin== | ||
| + | [[Exportin 3D structures]] | ||
| - | + | </StructureSection> | |
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== References == | == References == | ||
Current revision
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References
- ↑ Lipowsky G, Bischoff FR, Schwarzmaier P, Kraft R, Kostka S, Hartmann E, Kutay U, Gorlich D. Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes. EMBO J. 2000 Aug 15;19(16):4362-71. PMID:10944119 doi:http://dx.doi.org/10.1093/emboj/19.16.4362
- ↑ Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003 Dec 15;17(24):3011-6. Epub 2003 Dec 17. PMID:14681208 doi:http://dx.doi.org/10.1101/gad.1158803
- ↑ Kohler A, Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73. PMID:17786152 doi:http://dx.doi.org/10.1038/nrm2255
- ↑ Cook AG, Fukuhara N, Jinek M, Conti E. Structures of the tRNA export factor in the nuclear and cytosolic states. Nature. 2009 Sep 3;461(7260):60-5. PMID:19680239 doi:10.1038/nature08394
