Anthrax protective antigen
From Proteopedia
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== Function == | == Function == | ||
| - | '''Anthrax protective antigen''' (PA) is the cell-binding part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of the PA, lethal factor and edema factor. | + | '''Anthrax protective antigen''' (PA) is the cell-binding part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of the PA, lethal factor and edema factor. The PA translocates the [[Anthrax Lethal Factor|lethal]] (LF) and [[Anthrax edema factor|edema]] factors (EF) into the cell. The 83kD form of PA '''(PA83)''' binds to the anthrax toxin receptor. A 20kD fragment (PA20) is cleaved off the PA83 and the remaining '''PA63''' assembles into ring-shaped oligomer which becomes a membrane pre-channel. The PA pre-channel binds the lethal and edema factors allowing them to penetrate the membrane via pH gradient. |
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| + | For more details see | ||
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| + | *[[Molecular Playground/Protective Antigen]]<br /> | ||
| + | *[[Anthrax Toxin Protein]]<br /> | ||
| + | *[[Toxins]]. | ||
== Structural highlights == | == Structural highlights == | ||
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==3D structures of anthrax protective antigen== | ==3D structures of anthrax protective antigen== | ||
| - | [[Anthrax protective antigen 3D structures | + | [[Anthrax protective antigen 3D structures]] |
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of anthrax protective antigen== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *PA83 | ||
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| - | **[[1acc]], [[3tew]], [[3q8a]], [[3q8b]], [[4h2a]] – PA<br /> | ||
| - | **[[3tex]], [[3tey]], [[3tez]], [[3q8c]], [[3q8e]], [[4ee2]], [[4nam]], [[5fr3]] – PA (mutant)<br /> | ||
| - | **[[3mhz]], [[3q8f]] – PA with fluoro-histidine<br /> | ||
| - | **[[1t6b]] – PA + anthrax toxin receptor A/I domain | ||
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| - | *PA63 | ||
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| - | **[[3hvd]] – PA63 (mutant)<br /> | ||
| - | **[[1tzo]] – PA63<br /> | ||
| - | **[[3j9c]] – PA63 C-terminal<br /> | ||
| - | **[[1tzn]] – PA63 + anthrax toxin receptor VWA domain<br /> | ||
| - | **[[3kwv]] – PA63 (mutant) + lethal factor | ||
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| - | *PA domain 4 | ||
| - | **[[3ino]] – PA domain 4<br /> | ||
| - | **[[3etb]] – PA domain 4 + antibody (mutant) | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Petosa C, Collier RJ, Klimpel KR, Leppla SH, Liddington RC. Crystal structure of the anthrax toxin protective antigen. Nature. 1997 Feb 27;385(6619):833-8. PMID:9039918 doi:10.1038/385833a0
