Apoptotic protease-activating factor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Apoptosis protease-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>. | + | '''Apoptosis protease-activating factor-1''' or '''Apoptosis peptidase-activating factor-1''' (APAF-1) binds to cytochrome c and ATP to form the apoptosome which leads to the recruitment and activation of caspase 9 by cleaving the procaspase 9. Caspase 9 is involved in executing the apoptosis of cells<ref>PMID:15829969</ref>. |
== Disease == | == Disease == | ||
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</StructureSection> | </StructureSection> | ||
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| - | ==3D structures of apoptotic protease-activating factor-1== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | [[2ygs]], [[1cy5]], [[2p1h]] – hAPAF-1 CARD domain – human <br /> | ||
| - | [[1c15]], [[1cww]] – hAPAF-1 CARD domain – NMR <br /> | ||
| - | [[1z6t]] – hAPAF-1 + ADP <br /> | ||
| - | [[3ygs]] – hAPAF-1 CARD domain + procaspase 9 <br /> | ||
| - | [[4rhw]], [[5wvc]] – hAPAF-1 CARD domain + caspase 9 <br /> | ||
| - | [[3j2t]], [[3jbt]] – hAPAF-1 + cytochrome c<br /> | ||
| - | [[5juy]], [[5wve]] – hAPAF-1 + caspase 9 + cytochrome c<br /> | ||
| - | [[3sfz]] – mAPAF-1 + ADP - mouse <br /> | ||
| - | [[3shf]] – mAPAF-1 (mutant) + ADP <br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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References
- ↑ Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y. Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature. 2005 Apr 14;434(7035):926-33. PMID:15829969 doi:10.1038/nature03465
- ↑ Furukawa Y, Sutheesophon K, Wada T, Nishimura M, Saito Y, Ishii H, Furukawa Y. Methylation silencing of the Apaf-1 gene in acute leukemia. Mol Cancer Res. 2005 Jun;3(6):325-34. PMID:15972851 doi:http://dx.doi.org/10.1158/1541-7786.MCR-04-0105
- ↑ Shalaeva DN, Dibrova DV, Galperin MY, Mulkidjanian AY. Modeling of interaction between cytochrome c and the WD domains of Apaf-1: bifurcated salt bridges underlying apoptosome assembly. Biol Direct. 2015 May 27;10:29. doi: 10.1186/s13062-015-0059-4. PMID:26014357 doi:http://dx.doi.org/10.1186/s13062-015-0059-4
