Antifreeze protein
From Proteopedia
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== Function == | == Function == | ||
| - | '''Antifreeze protein''' (AFP) permits the survival of certain organisms in subzero temperatures. AFP binds to small ice crystals thus inhibiting their growth.<ref>PMID:15152087</ref><br /> | + | '''Antifreeze protein''' (AFP) permits the survival of certain organisms in subzero temperatures. AFP binds to small ice crystals thus inhibiting their growth.<ref>PMID:15152087</ref>. There are 3 types of AFP which differ in the ice crusts face to which they bind<ref>PMID:33317024</ref>.<br /> |
| + | *'''AFP I''' is Ala-rich and alpha helical<br /> | ||
| + | *'''AFP II''' is Cys-rich and globular<br /> | ||
| + | *'''AFP III''' is globular<br /> | ||
* For winter flounder antifreeze protein type I see [[User:Mary Ball/AFP]].<br /> | * For winter flounder antifreeze protein type I see [[User:Mary Ball/AFP]].<br /> | ||
* For snow flea antifreeze protein see [[Sandox 2pne]] | * For snow flea antifreeze protein see [[Sandox 2pne]] | ||
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of antifreeze protein == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *AFP I | ||
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| - | **[[3p4g]] – MpAFP Ca-dependent residues 997-1318 – ''Marinomonas primoryensis''<BR /> | ||
| - | **[[4kdv]], [[4kdw]] – MpAFP Igg-like domain residues 101-204<br /> | ||
| - | **[[5ix9]] – MpAFP anchoring domain residues 12-187 (mutant) - NMR<br /> | ||
| - | **[[5k8g]] – MpAFP peptide-binding domain residues 205-723 <br /> | ||
| - | **[[5j6y]] – MpAFP PA14 domain residues 716-903 <br /> | ||
| - | **[[5juh]] – MpAFP C-terminal domain residues 1386-1567 <br /> | ||
| - | **[[3bog]], [[3boi]], [[2pne]] – AFP glycine-rich – ''Hypogastrura harveyi''<BR /> | ||
| - | **[[1z2f]], [[1eww]] – sbAFP – spruce budworm – NMR<BR /> | ||
| - | **[[1m8n]] – sbAFP<BR /> | ||
| - | **[[1l0s]] – sbAFP (mutant) <BR /> | ||
| - | **[[1j5b]] – wfAFP I (mutant) – winter flounder – NMR<BR /> | ||
| - | **[[1wfa]], [[1wfb]], [[4ke2]] – wfAFP I <br /> | ||
| - | **[[1ezg]] – TmAFP – ''Tenebrio molitor''<br /> | ||
| - | **[[1l1i]] – TmAFP – NMR<br /> | ||
| - | **[[1y03]], [[1y04]] - AFP – ''Myoxocephalus scorpius'' - NMR<br /> | ||
| - | **[[3uyu]], [[3uyv]] – AFP residues 21-261 – arctic yeast<br /> | ||
| - | **[[1n4i]] – AFP – ''Choristoneura fumiferana''<br /> | ||
| - | **[[3vn3]] – AFP – snow mold fungus<br /> | ||
| - | **[[4dt5]] – AFP – ''Rhagium inquisitor''<br /> | ||
| - | **[[4nu2]], [[4nu3]], [[3wp9]] – AFP – ''Flavobacterium frigoris''<br /> | ||
| - | **[[4nuh]] – AFP – ''Leucosporidium''<br /> | ||
| - | **[[5b5h]] – AFP – ''Typhula ishikariensis''<br /> | ||
| - | **[[6eio]] – AFP – uncultured bacteria<br /> | ||
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| - | *AFP II | ||
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| - | **[[2py2]] – AFP II – Atlantic herring<BR /> | ||
| - | **[[2afp]] – AFP II – sea raven - NMR<BR /> | ||
| - | **[[2zib]] – AFP II Ca-independent – ''Brachyopsis rostratus'' | ||
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| - | *AFP III | ||
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| - | **[[3qf6]] – opAFP III – ocean pout – Neutron<BR /> | ||
| - | **[[1ops]], [[4ny6]] – opAFP III<BR /> | ||
| - | **[[1hg7]], [[1b7i]], [[1b7j]], [[2ame]], [[1b7k]], [[1ekl]], [[1jab]], [[1msj]], [[2jia]], [[2msj]], [[3ame]], [[4ame]], [[6ame]], [[7ame]], [[8ame]], [[8msi]], [[9ame]], [[2spg]], [[9msi]], [[2msi]], [[3msi]], [[4msi]], [[5msi]], [[6msi]], [[7msi]], [[1ame]], [[1msi]], [[1gzi]] – opAFP III (mutant) <BR /> | ||
| - | **[[1kde]], [[1kdf]] - opAFP III (mutant) - NMR<BR /> | ||
| - | **[[1ucs]], [[4ur4]], [[4ur6]] – aepAFP III – Atlantic eel pout<BR /> | ||
| - | **[[3nla]], [[3rdn]] - aepAFP III N terminal]] - NMR<BR /> | ||
| - | **[[1c89]], [[1c8a]] – AFP III – ''Pachycara brachycephalum'' - NMR<BR /> | ||
| - | **[[5xqn]], [[5xqp]] – ZeAFP III – ''Zoarces elongatus'' <br /> | ||
| - | **[[2lx2]], [[2lx3]] – ZeAFP III - NMR<br /> | ||
| - | **[[5xqr]], [[5xqu]], [[5xqv]], [[5xr0]] – ZeAFP III (mutant)<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Jorov A, Zhorov BS, Yang DS. Theoretical study of interaction of winter flounder antifreeze protein with ice. Protein Sci. 2004 Jun;13(6):1524-37. PMID:15152087 doi:http://dx.doi.org/10.1110/ps.04641104
- ↑ Eskandari A, Leow TC, Rahman MBA, Oslan SN. Antifreeze Proteins and Their Practical Utilization in Industry, Medicine, and Agriculture. Biomolecules. 2020 Dec 9;10(12):1649. PMID:33317024 doi:10.3390/biom10121649
- ↑ Kondo H, Hanada Y, Sugimoto H, Hoshino T, Garnham CP, Davies PL, Tsuda S. Ice-binding site of snow mold fungus antifreeze protein deviates from structural regularity and high conservation. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9360-5. Epub 2012 May 29. PMID:22645341 doi:10.1073/pnas.1121607109
