User:Josephine Thestrup/Sandbox 1
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Histone Deacetylase 8 from ''Homo Sapiens'' | Histone Deacetylase 8 from ''Homo Sapiens'' | ||
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This is a default text for your page '''Josephine Thestrup/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Josephine Thestrup/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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| + | <Structure load='2v5w' size='400' frame='true' align='right' caption='Human Histone Deacetylase 8 homodimer,pdb:2v5w' scene='Insert optional scene name here' /> | ||
= Introduction= | = Introduction= | ||
| + | <scene name='81/811087/Active_site_loop_1_s30-k36/13'>Ser39</scene> | ||
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= Function = | = Function = | ||
= Structural highlights = | = Structural highlights = | ||
| - | [[Image:Hdac_8_overview.png ]] | + | [[Image:Hdac_8_overview.png|200 px|left|thumb|HDAC 8 structure overview ]] |
== Enzymatic mechanism == | == Enzymatic mechanism == | ||
| + | <scene name='81/811087/Active_site_hdac8/1'>Active</scene> | ||
| + | <scene name='81/811087/Active_site_loop_1_s30-k36/4'>N-Terminus L1 loop</scene> | ||
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| + | <scene name='81/811087/Asp_to_the_ligand/1'>The crucial Asp 101 interacting with the ligand at the rim of the active site</scene> | ||
= Inhibitors = | = Inhibitors = | ||
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| + | <scene name='81/811087/Ligand_interaction/2'>Asp101, Phe152 and Phe208</scene> | ||
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| + | <scene name='81/811087/Active_site_loop_1_s30-k36/10'>Ser39</scene> | ||
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= Medical relevance = | = Medical relevance = | ||
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| + | <scene name='81/811087/Inhibitor_and_zinc_binding/2'>Compound 1 (HDAC class 1 hydroxamic acid inhibitor) binding to the Zn2+ in a bidentate fashion</scene> | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
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| + | <scene name='81/811087/Inhibitor_and_zinc_binding/4'>His142,His143 and Tyr306</scene> | ||
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| + | <scene name='81/811087/Inhibitor_and_zinc_binding/9'>at the active site of HDAC8</scene> | ||
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| + | <scene name='81/811087/Active_site_loop_1_s30-k36/11'>N-Terminus L1 loop</scene> | ||
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| + | <scene name='81/811087/Active_site_loop_1_s30-k36/12'>Ser39</scene> | ||
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| + | <scene name='81/811087/Inhibitor_and_zinc_binding/10'>Amino acid derived</scene> | ||
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| + | <scene name='81/811087/Inhibitor_and_zinc_binding/13'>binds to the zinc ion</scene> | ||
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| + | <scene name='81/811087/Potassium_ion/2'>potassium ions</scene> | ||
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| + | <scene name='81/811087/Ligand_interaction/4'>Asp101,Phe152 and Phe208</scene> | ||
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| + | <scene name='81/811087/Ligand_interaction/5'>Asp101</scene> | ||
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| + | <scene name='81/811087/Active_site_loop_1_s30-k36/14'>N-Terminus L1 loop</scene> | ||
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| + | <scene name='81/811087/Potassium_ion/4'>Asp178 and His180</scene> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Histone Deacetylase 8 from Homo Sapiens
This is a default text for your page Josephine Thestrup/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
|
Contents |
Introduction
Function
Structural highlights
Enzymatic mechanism
Inhibitors
Medical relevance
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
