Tubulin tyrosine ligase

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== Structural highlights ==
== Structural highlights ==
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<scene name='70/707399/Cv/2'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/3'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/4'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>.
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<scene name='70/707399/Cv/5'>Tubulin tyrosine ligase complex with α-tubulin (2 chains), β-tubulin (2 chains), and stathmin</scene>. TTL structure is composed of <scene name='70/707399/Cv/6'>N-terminal, central and C-terminal domains</scene>. <scene name='70/707399/Cv/7'>TTL interacts with α- and β-tubulin</scene> via 3 loops and one helix terminal<ref>PMID:23358242</ref>.
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</StructureSection>
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== 3D Structures of tubulin tyrosine ligase ==
== 3D Structures of tubulin tyrosine ligase ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Tubulin tyrosine ligase 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Tubulin tyrosine ligase
 
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**[[3tig]] – fTTL - frog<br />
 
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**[[3tii]] – fTTL + ATP derivative <br />
 
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**[[3tin]] – fTTL + ADP <br />
 
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*Tubulin tyrosine ligase complex with tubulin
 
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**[[4iij]] – cTTL + rSTM + tubulin + GTP + GDP - chicken<br />
 
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**[[4ihj]] – cTTL + rSTM + tubulin + GTP + GDP + ADP <br />
 
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**[[6i5c]], [[4i55]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative <br />
 
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**[[5jqg]], [[5xp3]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative - pig <br />
 
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*Tubulin tyrosine ligase complex with tubulin and inhibitor
 
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**[[5xkf]], [[5xkg]] – cTTL + rSTM + tubulin + GTP + GDP + inhibitor<br />
 
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**[[4o2a]], [[5fnv]], [[5ca1]] – cTTL + rSTM + tubulin + GTP + GDP + ADP + inhibitor<br />
 
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**[[4i50]] – cTTL + rSTM + tubulin + GTP + GDP + epothilone <br />
 
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**[[4o4l]], [[4tuy]], [[4tv8]], [[4yj2]], [[4yj3]], [[5j2t]], [[5xiw]] – cTTL + rSTM + tubulin + GTP + GDP + anti-cancer drugs<br />
 
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**[[4o2b]], [[5lp6]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-gout drug<br />
 
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**[[4o4h]], [[4o4j]], [[4o4i]], [[5c8y]], [[5cb4]], [[5ca1]], [[5bmv]], [[5jh7]], [[5lxt]], [[4i4t]], [[5osk]], [[5xlt]], [[5xlz]], [[5mw1]], [[6fii]], [[6fjm]], [[5xag]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + anti-cancer drug<br />
 
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**[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fjf]], [[6fkj]], [[6fkl]], [[5xhc]], [[5xi5]], [[5xi7]] – cTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor<br />
 
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**[[5iyz]], [[5j2t]], [[5j2u]], [[5la6]], [[5bmv]], [[5jh7]] – bTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor - bovine<br />
 
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**[[4zhq]], [[4zi7]], [[4zol]], [[5c8y]], [[5fnv]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5lov]], [[5lyj]], [[5m7e]], [[5njh]], [[5lxs]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor <br />
 
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**[[5iyz]] – pTTL + rSTM + tubulin + GTP + GDP + ATP derivative + auristatin <br />
 
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**[[5cb4]] – bpTTL + rSTM + tubulin + GTP + GDP + ATP derivative + inhibitor – bearded pig<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Tubulin tyrosine ligase (cyan) complex with α-tubulin (grey and pink), β-tubulin (green and yellow), stathmin (magenta), MES, GTP, Ca+2, Cl- and Mg+2 ions (PDB code 4iij)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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