6j2s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of HitA bound to gallium from Pseudomonas aeruginosa== | |
| + | <StructureSection load='6j2s' size='340' side='right'caption='[[6j2s]], [[Resolution|resolution]] 1.73Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6j2s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J2S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J2S FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7300512Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GA:GALLIUM+(III)+ION'>GA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j2s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j2s OCA], [https://pdbe.org/6j2s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j2s RCSB], [https://www.ebi.ac.uk/pdbsum/6j2s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j2s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9HVA8_PSEAE Q9HVA8_PSEAE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development. | ||
| - | + | Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514<ref>PMID:31475514</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Guo | + | <div class="pdbe-citations 6j2s" style="background-color:#fffaf0;"></div> |
| - | [[Category: Li | + | |
| - | [[Category: Sun | + | ==See Also== |
| - | [[Category: Xia | + | *[[ABC transporter 3D structures|ABC transporter 3D structures]] |
| + | *[[Ferric-binding protein|Ferric-binding protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Guo Y]] | ||
| + | [[Category: Li HY]] | ||
| + | [[Category: Sun HZ]] | ||
| + | [[Category: Xia W]] | ||
Current revision
Structure of HitA bound to gallium from Pseudomonas aeruginosa
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