6o8j
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6o8j is ON HOLD Authors: Fields, F.R., Lee, S.W. Description: Syn-safencin Category: Unreleased Structures Category: Lee, S.W [[Category: F...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Syn-safencin== | |
| + | <StructureSection load='6o8j' size='340' side='right'caption='[[6o8j]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6o8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_safensis Bacillus safensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O8J FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o8j OCA], [https://pdbe.org/6o8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o8j RCSB], [https://www.ebi.ac.uk/pdbsum/6o8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o8j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1L6ZNG9_BACIA A0A1L6ZNG9_BACIA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The ribosomally produced antimicrobial peptides of bacteria (bacteriocins) represent an unexplored source of membrane-active antibiotics. We designed a library of linear peptides from a circular bacteriocin and show that pore-formation dynamics in bacterial membranes are tunable via selective amino acid substitution. We observed antibacterial interpeptide synergy indicating that fundamentally altering interactions with the membrane enables synergy. Our findings suggest an approach for engineering pore-formation through rational peptide design and increasing the utility of novel antimicrobial peptides by exploiting synergy. | ||
| - | + | Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy.,Fields FR, Manzo G, Hind CK, Janardhanan J, Foik IP, Carmo Silva PD, Balsara RD, Clifford M, Vu HM, Ross JN, Kalwajtys VR, Gonzalez AJ, Bui TT, Ploplis VA, Castellino FJ, Siryaporn A, Chang M, Sutton JM, Mason AJ, Lee S ACS Pharmacol Transl Sci. 2020 Feb 21;3(3):418-424. doi:, 10.1021/acsptsci.0c00001. eCollection 2020 Jun 12. PMID:32566907<ref>PMID:32566907</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6o8j" style="background-color:#fffaf0;"></div> |
| - | [[Category: Fields | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus safensis]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fields FR]] | ||
| + | [[Category: Lee SW]] | ||
Current revision
Syn-safencin
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