6o9m

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(New page: '''Unreleased structure''' The entry 6o9m is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (14:51, 13 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6o9m is ON HOLD
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==Structure of the human apo TFIIH==
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<SX load='6o9m' size='340' side='right' viewer='molstar' caption='[[6o9m]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6o9m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O9M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o9m OCA], [https://pdbe.org/6o9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o9m RCSB], [https://www.ebi.ac.uk/pdbsum/6o9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o9m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ERCC2_HUMAN ERCC2_HUMAN] Trichothiodystrophy;COFS syndrome;Xeroderma pigmentosum complementation group D. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ERCC2_HUMAN ERCC2_HUMAN] ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.<ref>PMID:10024882</ref> <ref>PMID:15494306</ref> <ref>PMID:20797633</ref> <ref>PMID:8413672</ref>
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Authors:
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==See Also==
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*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dodd T]]
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[[Category: He Y]]
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[[Category: Ivanov I]]
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[[Category: Tainer JA]]
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[[Category: Tsutakawa SE]]
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[[Category: Yan CL]]

Current revision

Structure of the human apo TFIIH

6o9m, resolution 4.40Å

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OCA

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