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2cip

From Proteopedia

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[[Image:2cip.gif|left|200px]]<br />
 
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<applet load="2cip" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2cip, resolution 1.40&Aring;" />
 
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'''STRUCTURE OF THE MICHAELIS COMPLEX OF A FAMILY 26 LICHENASE'''<br />
 
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==About this Structure==
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==Structure of the Michaelis complex of a family 26 lichenase==
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2CIP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_thermocellum Clostridium thermocellum] with ZZ1 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cellulase Cellulase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.4 3.2.1.4] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CIP OCA].
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<StructureSection load='2cip' size='340' side='right'caption='[[2cip]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2cip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetivibrio_thermocellus Acetivibrio thermocellus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PRD_900024:beta-laminaribiose'>PRD_900024</scene>, <scene name='pdbligand=ZZ1:4-METHYL-2H-CHROMEN-2-ONE'>ZZ1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cip OCA], [https://pdbe.org/2cip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cip RCSB], [https://www.ebi.ac.uk/pdbsum/2cip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cip ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GUNH_ACET2 GUNH_ACET2] This enzyme catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cip_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cip ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases., Money VA, Smith NL, Scaffidi A, Stick RV, Gilbert HJ, Davies GJ, Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5136-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16823793 16823793]
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*[[Glucanase 3D structures|Glucanase 3D structures]]
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[[Category: Cellulase]]
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__TOC__
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[[Category: Clostridium thermocellum]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Acetivibrio thermocellus]]
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[[Category: Davies, G.J.]]
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[[Category: Large Structures]]
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[[Category: Gilbert, H.J.]]
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[[Category: Davies GJ]]
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[[Category: Money, V.A.]]
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[[Category: Gilbert HJ]]
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[[Category: Scaffidi, A.]]
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[[Category: Money VA]]
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[[Category: Smith, N.L.]]
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[[Category: Scaffidi A]]
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[[Category: Stick, R.V.]]
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[[Category: Smith NL]]
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[[Category: ZZ1]]
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[[Category: Stick RV]]
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[[Category: 3 glucanase]]
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[[Category: 4 beta-1]]
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[[Category: beta-1]]
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[[Category: carbohydrate metabolism]]
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[[Category: cellulose degradation]]
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[[Category: glycosidase]]
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[[Category: glycoside hydrolase]]
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[[Category: hydrolase]]
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[[Category: lichenase]]
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[[Category: michaelis complex]]
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[[Category: polysaccharide degradation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 18:10:15 2007''
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Current revision

Structure of the Michaelis complex of a family 26 lichenase

PDB ID 2cip

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