6r1l
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6r1l is ON HOLD Authors: Reddem, R., Thunnissen, A.M.W.H. Description: Crystal structure of LmrR with bound copper phenanthroline [[Category: Unrel...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of LmrR with bound copper phenanthroline== | |
| + | <StructureSection load='6r1l' size='340' side='right'caption='[[6r1l]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6r1l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._cremoris_MG1363 Lactococcus lactis subsp. cremoris MG1363]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R1L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.095Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=PHN:1,10-PHENANTHROLINE'>PHN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r1l OCA], [https://pdbe.org/6r1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r1l RCSB], [https://www.ebi.ac.uk/pdbsum/6r1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r1l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A2RI36_LACLM A2RI36_LACLM] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We present an artificial metalloenzyme based on the transcriptional regulator LmrR that exhibits dynamics involving the positioning of its abiological metal cofactor. The position of the cofactor, in turn, was found to be related to the preferred catalytic reactivity, which is either the enantioselective Friedel-Crafts alkylation of indoles with beta-substituted enones or the tandem Friedel-Crafts alkylation/enantioselective protonation of indoles with alpha-substituted enones. The artificial metalloenzyme could be specialized for one of these catalytic reactions introducing a single mutation in the protein. The relation between cofactor dynamics and activity and selectivity in catalysis has not been described for natural enzymes and, to date, appears to be particular for artificial metalloenzymes. | ||
| - | + | Cofactor Binding Dynamics Influence the Catalytic Activity and Selectivity of an Artificial Metalloenzyme.,Villarino L, Chordia S, Alonso-Cotchico L, Reddem E, Zhou Z, Thunnissen AMWH, Marechal JD, Roelfes G ACS Catal. 2020 Oct 16;10(20):11783-11790. doi: 10.1021/acscatal.0c01619. Epub, 2020 Sep 18. PMID:33101759<ref>PMID:33101759</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Reddem | + | <div class="pdbe-citations 6r1l" style="background-color:#fffaf0;"></div> |
| - | [[Category: Thunnissen | + | |
| + | ==See Also== | ||
| + | *[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lactococcus lactis subsp. cremoris MG1363]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Reddem R]] | ||
| + | [[Category: Thunnissen AMWH]] | ||
Current revision
Crystal structure of LmrR with bound copper phenanthroline
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