6n1z

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<StructureSection load='6n1z' size='340' side='right'caption='[[6n1z]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6n1z' size='340' side='right'caption='[[6n1z]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6n1z]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N1Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6n1z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N1Z FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1z OCA], [http://pdbe.org/6n1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n1z RCSB], [http://www.ebi.ac.uk/pdbsum/6n1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1z ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1z OCA], [https://pdbe.org/6n1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n1z RCSB], [https://www.ebi.ac.uk/pdbsum/6n1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IPO9_HUMAN IPO9_HUMAN]] Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains (PubMed:11823430). Mediates the nuclear import of actin (By similarity).[UniProtKB:Q91YE6]<ref>PMID:11823430</ref> [[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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[https://www.uniprot.org/uniprot/H2A1_XENLA H2A1_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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== References ==
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<references/>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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*[[Importin 3D structures|Importin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chook, Y M]]
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[[Category: Xenopus laevis]]
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[[Category: Padavannil, A]]
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[[Category: Chook YM]]
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[[Category: Tomchick, D R]]
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[[Category: Padavannil A]]
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[[Category: H2a]]
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[[Category: Tomchick DR]]
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[[Category: H2b]]
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[[Category: Histone]]
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[[Category: Histone chaperone]]
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[[Category: Importin-9]]
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[[Category: Karyopherin]]
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[[Category: Nl]]
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[[Category: Nuclear pore complex]]
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[[Category: Nucleosome]]
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[[Category: Ran gtpase]]
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[[Category: Transport protein]]
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Current revision

Importin-9 bound to H2A-H2B

PDB ID 6n1z

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