4c9y

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<StructureSection load='4c9y' size='340' side='right'caption='[[4c9y]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='4c9y' size='340' side='right'caption='[[4c9y]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4c9y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C9Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4c9y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C9Y FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ca0|4ca0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9y OCA], [http://pdbe.org/4c9y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c9y RCSB], [http://www.ebi.ac.uk/pdbsum/4c9y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c9y OCA], [https://pdbe.org/4c9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c9y RCSB], [https://www.ebi.ac.uk/pdbsum/4c9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c9y ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/SKA1_HUMAN SKA1_HUMAN]] Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.<ref>PMID:17093495</ref> <ref>PMID:19289083</ref>
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Abad, M]]
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[[Category: Abad M]]
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[[Category: Jayachandran, U]]
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[[Category: Jayachandran U]]
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[[Category: Jeyaprakash, A A]]
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[[Category: Jeyaprakash AA]]
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[[Category: Madhumalar, A]]
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[[Category: Madhumalar A]]
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[[Category: Medina, B]]
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[[Category: Medina B]]
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[[Category: Nigg, E A]]
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[[Category: Nigg EA]]
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[[Category: Plasberg-Hill, C]]
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[[Category: Plasberg-Hill C]]
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[[Category: Rappsilber, J]]
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[[Category: Rappsilber J]]
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[[Category: Redli, P M]]
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[[Category: Redli PM]]
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[[Category: Santamaria, A]]
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[[Category: Santamaria A]]
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[[Category: Zou, J]]
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[[Category: Zou J]]
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[[Category: Cell cycle]]
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[[Category: Cell divison]]
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[[Category: Kinetochore-microtubule attachment]]
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[[Category: Winged-helix domain]]
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Current revision

Structural Basis for the microtubule binding of the human kinetochore Ska complex

PDB ID 4c9y

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