Aldehyde dehydrogenase 3D structures

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Line 6: Line 6:
*ALDH class 1
*ALDH class 1
 +
**[[1hso]] – hALDH1 α subunit + Zn + NAD - human<br />
 +
**[[4wj9]] - hALDH1 (mutant) <br />
 +
**[[4wpn]] - hALDH1 + inhibitor<br />
 +
**[[4wp7]] - hALDH1 (mutant) + inhibitor<br />
 +
**[[4wb9]], [[8wfq]] - hALDH1 + NAD derivative <br />
 +
**[[4x4l]] - hALDH1 + NAD derivative + inhibitor<br />
 +
**[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD<br />
**[[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR />
**[[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR />
**[[1bxs]] – sALDH1 + NAD - sheep<br />
**[[1bxs]] – sALDH1 + NAD - sheep<br />
Line 14: Line 21:
**[[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br />
**[[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br />
**[[3rhm]] - rALDH1 C- terminal<br />
**[[3rhm]] - rALDH1 C- terminal<br />
-
**[[1hso]] – hALDH1 α subunit + Zn + NAD - human<br />
 
-
**[[4wj9]] - hALDH1 (mutant) <br />
 
-
**[[4wpn]] - hALDH1 + inhibitor<br />
 
-
**[[4wp7]] - hALDH1 (mutant) + inhibitor<br />
 
-
**[[4wb9]] - hALDH1 + NAD derivative <br />
 
-
**[[4x4l]] - hALDH1 + NAD derivative + inhibitor<br />
 
-
**[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD
 
-
*ALDH class 1 A (retinal dehydrogenase)
+
*ALDH family 1 A (retinal dehydrogenase)
-
**[[5l2m]], [[5l2n]], [[5l2o]] – hRALDH1 + inhibitor<br />
+
**[[4x4l]], [[5l2m]], [[5l2n]], [[5l2o]], [[7jws]], [[7jwt]], [[7jwu]], [[7jwv]], [[7jww]], [[8t0n]], [[8t0t]] – hRALDHA1 + inhibitor<br />
-
**[[5tei]] – hRALDH1 + NAD + inhibitor<br />
+
**[[8d46]], [[8dno]], [[8pvh]] – hRALDH1A1 – Cryo EM<br />
-
**[[6alj]], [[6b5g]], [[6b5h]], [[6b5i]] – hRALDH2 + NAD + inhibitor<br />
+
**[[8ene]] – hRALDH1A1 + NAD – Cryo EM<br />
-
**[[5fhz]] – hRALDH3 + NAD + retinol<br />
+
**[[4wb9]] – hRALDH1A1 + NAD <br />
 +
**[[5tei]], [[6dum]], [[7um9]] – hRALDH1A1 + NAD + inhibitor<br />
 +
**[[6alj]], [[6b5g]], [[6b5h]], [[6b5i]] – hRALDH1A22 + NAD + inhibitor<br />
 +
**[[7qk7]] – hRALDH1A3 <br />
 +
**[[7qk9]] – hRALDH1A3 + ATP<br />
 +
**[[5fhz]] – hRALDH1A3 + NAD + retinol<br />
 +
**[[6s6w]], [[6te5]], [[6try]], [[7a6q]], [[7qk8]] – hRALDH1A3 + NAD + inhibitor<br />
 +
**[[7mjc]] – hRALDH1B1 + NAD <br />
 +
**[[7mjd]], [[7rad]] – hRALDH1B1 + NAD + inhibitor<br />
 +
**[[5abm]] – sRALDHA1 + inhibitor<br />
 +
**[[7yob]] – mRALDHA1 - mouse<br />
*ALDH class 2
*ALDH class 2
 +
**[[8shs]] – hALDH2 – Cryo EM<br />
**[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517<BR />
**[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517<BR />
**[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR />
**[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR />
Line 39: Line 50:
**[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR />
**[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR />
**[[2vle]] - hALDH2 residues 24-517 + daidzin<BR />
**[[2vle]] - hALDH2 residues 24-517 + daidzin<BR />
-
**[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]], [[4x2q]] - hALDH2 residues 18-517 + NAD<BR />
+
**[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]], [[4x2q]], [[8dr9]]- hALDH2 residues 18-517 + NAD<BR />
**[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR />
**[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR />
**[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br />
**[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br />
Line 57: Line 68:
*ALDH class 3
*ALDH class 3
-
**[[1ad3]] – rALDH3<br />
 
**[[3sza]] - hALDH3A1<br />
**[[3sza]] - hALDH3A1<br />
**[[3szb]], [[4l1o]], [[4l2o]] – hALDH3A1 + inhibitor<br />
**[[3szb]], [[4l1o]], [[4l2o]] – hALDH3A1 + inhibitor<br />
 +
**[[8bb8]] – hALDH3A1 + octanal<br />
**[[4h80]] - hALDH3A1 (mutant) + inhibitor<br />
**[[4h80]] - hALDH3A1 (mutant) + inhibitor<br />
**[[4qgk]] – hALDH3A2 + ligand<br />
**[[4qgk]] – hALDH3A2 + ligand<br />
 +
**[[1ad3]] – rALDH3<br />
**[[5myp]] – TbALDH – ''Trypanosoma brucei''<br />
**[[5myp]] – TbALDH – ''Trypanosoma brucei''<br />
**[[5nno]] – TbALDH + NAD + inhibitor <br />
**[[5nno]] – TbALDH + NAD + inhibitor <br />
 +
 +
*ALDH family 4 (delta-1-pyrroline-5-carboxylate dehydrogenase)
 +
 +
**[[3v9g]], [[4oe5]] – hALDH4A1 <br />
 +
**[[3v9h]], [[3v9i]] – hALDH4A1 (mutant)<br />
 +
**[[3v9j]], [[4e3x]] – mALDH4A1 <br />
 +
**[[3v9k]] – mALDH4A1 + Glu<br />
 +
**[[4lh0]] – mALDH4A1 + glyoxylate<br />
 +
**[[4lh1]] – mALDH4A1 + malonate<br />
 +
**[[4lh2]] – mALDH4A1 + succinate<br />
 +
**[[4lh3]] – mALDH4A1 + glutarate<br />
 +
**[[4lgz]] – mALDH4A1 + acetate<br />
 +
**[[3v9l]] – mALDH4A1 + NAD<br />
 +
**[[7mer]], [[7mes]] – mALDH4A1 + Pro derivative<br />
 +
 +
*ALDH family 5 (succinate-semialdehyde dehydrogenase)
 +
 +
**[[2w8n]], [[2w8o]], [[2w8r]] – hALDH5A1 <br />
 +
**[[2w8p]] – hALDH5A1 (mutant)<br />
 +
**[[2w8q]] – hALDH5A1 + succinate<br />
 +
**[[3jz4]] - EcALDH5A1 + NADP<br />
 +
**[[4v6h]] - BpALDH5A1 – ''Burkholderia pseudomallei''<br />
 +
**[[3rh9]] - ALDH5A1 – ''Marinobacter aquaeolei''<br />
 +
 +
*ALDH family 7 (alpha-aminoadipic semialdehyde dehydrogenase)
 +
 +
**[[4zvw]], [[4zvx]], [[4zuk]] - hALDH7A1<br />
 +
**[[6o4d]] – hALDH7A1 + pipecolic acid<br />
 +
**[[2j6l]], [[4zvy]] – hALDH7A1 + NAD
 +
**[[6o4b]], [[6o4c]], [[6o4e]], [[6o4h]], [[6o4k]], [[6o4l]], [[6u2x]], [[6v0z]] – hALDH7A1 (mutant) + NAD<br />
 +
**[[6o4d]], [[6o4i]] – hALDH7A1 (mutant) + pipecolic acid<br />
 +
**[[4x0u]] - hALDH7A1 + inhibitor<br />
 +
**[[4zul]] - hALDH7A1 + a-aminoadipate<br />
 +
**[[6o4f]], [[6o4g]] - hALDH7A1 (mutant) + a-aminoadipate<br />
 +
**[[4x0t]] - hALDH7A1 + NAD+ inhibitor<br />
 +
 +
*ALDH family 9 (4-trimethylaminobutyraldehyde dehydrogenase)
 +
 +
**[[6qak]], [[6qao]], [[6qap]] – hALDH9A1 <br />
 +
**[[6vr6]], [[6vwf]] – hALDH9A1 + NAD<br />
*NAD-dependent ALDH
*NAD-dependent ALDH
-
**[[2w8n]], [[2w8o]], [[2w8r]] – Succinate–semi-hALDH family 5<BR />
 
-
**[[2w8p]] - Succinate–semi-hALDH family 5 (mutant) <BR />
 
-
**[[3r31]] – Betaine-ALDH – ''Agrobacterium tumefaciens''<BR />
 
-
**[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR />
 
-
**[[4qje]] - Betaine-SaALDH (mutant)<br />
 
-
**[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br />
 
-
**[[4cbb]], [[6bpg]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br />
 
-
**[[6bjp]] - Betaine-PaALDH (mutant)<br />
 
-
**[[1a4s]] - Betaine-cALDH - cod<BR />
 
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
**[[3vos]], [[3tz6]], [[3vos]] – Aspartate-semi-MtALDH<BR />
**[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR />
**[[2cq8]] - Formyltetrahydrofolate-hALDH PP-binding domain - NMR<BR />
 +
**[[7rlt]] - Formyltetrahydrofolate-rALDH1L1<br />
**[[2nac]] – Formate-PsALDH<BR />
**[[2nac]] – Formate-PsALDH<BR />
**[[3i44]] – ALDH – ''Bartonella henselae''<BR />
**[[3i44]] – ALDH – ''Bartonella henselae''<BR />
Line 89: Line 133:
**[[4qet]] – BcALDH (mutant)<br />
**[[4qet]] – BcALDH (mutant)<br />
**[[5uju]] - BmALDH – ''Burkholderia multivorans''<br />
**[[5uju]] - BmALDH – ''Burkholderia multivorans''<br />
-
**[[6fk3]], [[6fkv]], [[6fjv]] - TtALDH – ''Thermus thermophilus''<br />
+
**[[6fk3]], [[6fkv]], [[6fjx]] - TtALDH – ''Thermus thermophilus''<br />
*NAD-dependent ALDH binary complexes
*NAD-dependent ALDH binary complexes
-
**[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR />
 
-
**[[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR />
 
-
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br />
 
-
**[[1bpw]] - Betaine-cALDH + NAD<BR />
 
-
**[[4zvw]], [[4zvx]] - Aminoadipate-semi-hALDH family 7<br />
 
-
**[[2j6l]], [[4zvy]] – Aminoadipate-semi-hALDH family 7 + NAD<BR />
 
-
**[[4x0u]] - Aminoadipate-semi-hALDH family 7+ inhibitor<br />
 
-
**[[4zuk]] - Aminoadipate-semi-hALDH family 7+ NAD<br />
 
-
**[[4zul]] - Aminoadipate-semi-hALDH family 7+ α-aminoadipate<br />
 
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR />
-
**[[2nad]] - Formate-PaALDH + NAD <BR />
+
**[[7rlu]] - Formyltetrahydrofolate-rALDH1L1 + NADP <br />
-
**[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br />
+
**[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br />
**[[4a0m]], [[4v37]] – spALDH + NAD – spinach<br />
**[[4a0m]], [[4v37]] – spALDH + NAD – spinach<br />
**[[5a2d]], [[4v3f]] – spALDH + choline<br />
**[[5a2d]], [[4v3f]] – spALDH + choline<br />
**[[3iwk]] – amino-ALDH + NAD – pea<br />
**[[3iwk]] – amino-ALDH + NAD – pea<br />
 +
**[[2nad]] - Formate-PaALDH + NAD <BR />
 +
**[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br />
**[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD <br />
**[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD <br />
-
**[[4caz]] - Betaine-PaALDH + NAD derivative<br />
 
**[[4c3s]] - CpALDH + NAD <br />
**[[4c3s]] - CpALDH + NAD <br />
**[[5dbv]] - CpALDH + CoA <br />
**[[5dbv]] - CpALDH + CoA <br />
Line 127: Line 163:
**[[4i3x]] – SmALDH + phosphonoacete + NAD<br />
**[[4i3x]] – SmALDH + phosphonoacete + NAD<br />
**[[5jfm]] – RpALDH + CoA + propionyl-CoA<br />
**[[5jfm]] – RpALDH + CoA + propionyl-CoA<br />
-
**[[4x0t]] - Aminoadipate-semi-hALDH family 7 + NAD+ inhibitor<br />
 
*NADP-dependent ALDH
*NADP-dependent ALDH
-
**[[3k2w]] - Betaine-ALDH – ''Pseudoalteromonas atlantica''<BR />
+
**[[4gac]] – mALDH <br />
**[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR />
**[[2hg2]], [[2opx]] – Lactaldehyde-EcALDH <BR />
-
**[[2o2p]] – Formyltetrahydrofolate-rALDH C-terminal<br />
 
**[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br />
**[[2y51]], [[2y52]], [[2y53]], [[2y5d]] – BxALDH (mutant) – ''Burkholderia xenovorans''<br />
-
**[[4v6h]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br />
 
-
**[[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br />
 
**[[3uw3]] - aspartate–semi-BtALDH – ''Burkholderia thailandensis''<br />
**[[3uw3]] - aspartate–semi-BtALDH – ''Burkholderia thailandensis''<br />
**[[3v4c]] - SmALDH<br />
**[[3v4c]] - SmALDH<br />
-
**[[4gac]] – ALDH – mouse<br />
 
**[[5eeb]] - PfALDH – ''Pyrobaculum ferrireducens''<br />
**[[5eeb]] - PfALDH – ''Pyrobaculum ferrireducens''<br />
 +
**[[6j75]] – VvALDH – ''Vibrio variablis''<br />
 +
**[[6pnu]] – PfALDH – ''Pseudoalteromonas fuliginea''<br />
*NADP-dependent ALDH binary complexes
*NADP-dependent ALDH binary complexes
-
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - Betaine-PaALDH + NADP<BR />
+
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - PaBDH + NADP<BR />
**[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR />
**[[2ilu]] - Lactaldehyde-EcALDH + NADP<BR />
**[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br />
**[[3rhd]] - Lactaldehyde-MjALDH + NADP - ''Methanocaldococcus jannaschii''<br />
Line 150: Line 183:
**[[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR />
**[[3b4w]] - MtALDH + NADP – ''Mycobacterium tuberculosis''<BR />
**[[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi''<br />
**[[1eyy]], [[1ez0]] – ALDH + NADP – ''Vibrio harveyi''<br />
-
**[[3jz4]] - Succinate–semi-EcALDH + NADP<br />
 
**[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br />
**[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br />
**[[4h73]], [[4nmj]], [[4nmk]], [[5f2c]], [[5exf]], [[5euy]], [[5ekc]], [[5ek6]] - PfALDH + NADP <br />
**[[4h73]], [[4nmj]], [[4nmk]], [[5f2c]], [[5exf]], [[5euy]], [[5ekc]], [[5ek6]] - PfALDH + NADP <br />
Line 157: Line 189:
**[[5j6b]] - BtALDH + NADP <br />
**[[5j6b]] - BtALDH + NADP <br />
**[[5gtl]] – BcALDH + NADP<br />
**[[5gtl]] – BcALDH + NADP<br />
 +
**[[6j76]] – VvALDH + NADP<br />
 +
**[[6pop]] – PfALDH + NADP<br />
*NADP-dependent ALDH ternary complexes
*NADP-dependent ALDH ternary complexes
Line 163: Line 197:
**[[2vro]] – BxALDH + NADP + alcohol <br />
**[[2vro]] – BxALDH + NADP + alcohol <br />
-
*Indole-3-ALDH
+
*Indole-3-acetaldehyde dehydrogenase
**[[5iuu]] – PsIALDH – ''Pseudomonas syringae''<br />
**[[5iuu]] – PsIALDH – ''Pseudomonas syringae''<br />
**[[5iuv]] – PsIALDH + NAD<br />
**[[5iuv]] – PsIALDH + NAD<br />
-
**[[5iuw]] – PsIALDH + NAD + indole acetate<br />
+
**[[5iuw]], [[7jso]] – PsIALDH + NAD + indole acetate<br />
-
*NAD-dependent glyceraldehydes-3-phosphate dehydrogenase
+
*NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
**[[1vsu]] – CpGAPDH – ''Cryptosporidium parvum''<br />
Line 243: Line 277:
**[[1uxq]] - TtGAPDH (mutant) + NADP + G1P<br />
**[[1uxq]] - TtGAPDH (mutant) + NADP + G1P<br />
**[[1uxr]] - TtGAPDH (mutant) + NADP + F6P
**[[1uxr]] - TtGAPDH (mutant) + NADP + F6P
 +
 +
*NAD/NADP-dependent betaine ALDH
 +
 +
**[[1a4s]] - cBADH – cod<br />
 +
**[[1bpw]] - cBADH + NAD<br />
 +
**[[3r31]] – BADH – ''Agrobacterium tumefaciens''<br />
 +
**[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - SaBADH – ''Staphylococcus aureus''<br />
 +
**[[4qje]] - SaBADH (mutant)<br />
 +
**[[4zxu]], [[4zwl]] - SaBADH (mutant) + NAD<br />
 +
**[[4cbb]], [[6bpg]] - PaBADH - ''Pseudomonas aeruginosa''<br />
 +
**[[6bjp]] - PaBADH (mutant)<br />
 +
**[[4mpy]], [[4nea]] - SaBADH + NAD<br />
 +
**[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - SaBADH (mutant) + NAD<br />
 +
**[[4caz]] - PaBADH + NAD derivative<br />
 +
**[[3k2w]] - BADH – ''Pseudoalteromonas atlantica''<br />
 +
**[[6wsa]] - BpBADH<br />
 +
**[[6wsb]] - BpBADH + NAD<br />
 +
**[[2wox]], [[2wme]], [[2xdr]], [[3zqa]] - PaBADH + NADP<br />
 +
**[[3k2w]] - BADH – ''Pseudoalteromonas atlantica''<BR />
 +
**[[7swk]] – KpBADH – ''Klebsiella pneumoniae''<br />
 +
**[[8u9b]] – KpBADH (mutant) <br />
 +
**[[8uzo]] – KpBADH + ADP<br />
 +
**[[8uzn]], [[8vqz]], [[8vr0]], [[8vr1]] – KpBADH (mutant) + nucleotide<br />
 +
**[[8uzi]] – KpBADH (mutant) + betaine<br />
 +
**[[8skf]] – KpBADH (mutant) + NAD<br />
 +
**[[8uzk]], [[8uzm]] – KpBADH (mutant) + NADP<br />
*Uncharacterized ALDH
*Uncharacterized ALDH
Line 253: Line 313:
**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5mz8]] – PhpALDH 21 + succinate<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
**[[5n5s]] – PhpALDH 21 + NADP<br />
 +
**[[8of3]] – PhpALDH 5F1 (mutant)<br />
 +
**[[8ofm]] – PhpALDH 5F1 + NAD<br />
**[[6mvr]] – LoALDH 16 - ''Loktanella''<br />
**[[6mvr]] – LoALDH 16 - ''Loktanella''<br />
**[[6mvu]] – LoALDH 16 (mutant)<br />
**[[6mvu]] – LoALDH 16 (mutant)<br />
**[[6mvs]], [[6mvt]] – LoALDH 16 + NAD<br />
**[[6mvs]], [[6mvt]] – LoALDH 16 + NAD<br />
 +
**[[6ahc]] – EcALDH – Cryo EM<br />
 +
**[[6k0z]] - SaALDH<br />
 +
**[[6k10]] – SaALDH (mutant)<br />
 +
**[[8hap]] – ALDH +MPADP – ''Sulfurisphaera tokodaii''<br />
 +
**[[7uyy]] – PaALDH + NAD<br />
 +
**[[8ixi]] - KpALDH<br />
*Antiquitin
*Antiquitin

Current revision

3D Structures of Aldehyde dehydrogenase

Updated on 18-September-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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