User:Andrew Hesterhagen/Sandbox 1
From Proteopedia
< User:Andrew Hesterhagen(Difference between revisions)
| (27 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | =Lysine Specific Demethylase (''Homo Sapiens'')= | + | {{Reflist}}<scene name='81/811710/Fad_n5/1'>Text To Be Displayed</scene>=Lysine Specific Demethylase (''Homo Sapiens'')= |
| - | <StructureSection load='2h94' size=' | + | ==Your Heading Here (maybe something like 'Structure')== |
| + | <StructureSection load='2h94' size='350' side='right' caption='Lysine Demthylase (PDB entry [[2h94]])' scene=''> | ||
| + | |||
| + | Anything in this section will appear adjacent to the 3D structure and will be scrollable. | ||
| + | |||
This is a default text for your page '''Andrew Hesterhagen/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Andrew Hesterhagen/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== Introduction == | == Introduction == | ||
| + | <scene name='81/811710/Fad_n5/4'>NOWWWWW</scene> | ||
===SWIRM Domain=== | ===SWIRM Domain=== | ||
[[Image:pic_numbah_4.png|400 px|left|thumb|Figure 1]] | [[Image:pic_numbah_4.png|400 px|left|thumb|Figure 1]] | ||
| + | <scene name='81/811710/Fad_highlight/3'>Wozzzzzz</scene> | ||
== Disease == | == Disease == | ||
[http://www.reddit.com Reddit] | [http://www.reddit.com Reddit] | ||
| + | ==Regulation== | ||
| + | === Allosteric Stie === | ||
| + | LSD-1 can be regulated by outside factors. The tower domain and oxidase domain are connected by a <scene name='81/811710/Tower_domain/1'>tower oxidase domain</scene>. The oxidase domain is what harbors the catalytic chamber for LSD-1. Any change to the catalytic chamber could drastically reduce the ability for the methylated lysine of the substrate to fit in the binding site correctly. Because the tower domain is attached to the oxidase domain, the tower domain and the connector region may allosterically regulate demethylase activity. Any interaction with these two sites is hypothesized to change the enzyme activity. This has further pushed the assumption that the CoRest complex effects enzyme activity via interaction with the tower domain.<ref>PMID:16799558</ref> | ||
| + | ===Androgen Receptor=== | ||
| + | LSD-1 will demethylate mono or di-methylated lysines. It will only demethylate lysine 4 of histone 3. This factor can be regulated by the androgen receptor which can change its specificity for a different target.<ref>PMID:16799558</ref> The [http://proteopedia.org/wiki/index.php/Androgen_receptor#Function androgen receptor] is a steroid hormone receptor that can modulate transcription. When it interacts with LSD-1 it will no longer demethylate H3-K4, but will now demethylate H3-K9. This attribute allows LSD-1 to work on a wider range of residues.<ref>PMID:16799558</ref> | ||
== Relevance == | == Relevance == | ||
| - | + | <scene name='81/811710/Fad_n5/3'>No merc</scene> | |
== Structural highlights == | == Structural highlights == | ||
| + | Hey <scene name='81/811710/Fad_highlight/1'>this</scene> will show the FAD | ||
| + | And <scene name='81/811710/Oxidase/1'>thisssss</scene> will show you the oxidase domain | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| Line 17: | Line 30: | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | <ref name=”Ransey”>PMID:28504306</ref> | ||
| + | <ref name=”Structure”>PMID:1599895</ref> | ||
| + | <ref name="Stavropoulos">PMID:16799558</ref> | ||
<references/> | <references/> | ||
Current revision
Your Heading Here (maybe something like 'Structure')
| |||||||||||
References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Stavropoulos P, Blobel G, Hoelz A. Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol. 2006 Jul;13(7):626-32. Epub 2006 Jun 25. PMID:16799558 doi:10.1038/nsmb1113
- ↑ Stavropoulos P, Blobel G, Hoelz A. Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol. 2006 Jul;13(7):626-32. Epub 2006 Jun 25. PMID:16799558 doi:10.1038/nsmb1113
- ↑ Stavropoulos P, Blobel G, Hoelz A. Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol. 2006 Jul;13(7):626-32. Epub 2006 Jun 25. PMID:16799558 doi:10.1038/nsmb1113
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Mineo R, Sharrock NE. Venous levels of lidocaine and bupivacaine after midtarsal ankle block. Reg Anesth. 1992 Jan-Feb;17(1):47-9. PMID:1599895
- ↑ Stavropoulos P, Blobel G, Hoelz A. Crystal structure and mechanism of human lysine-specific demethylase-1. Nat Struct Mol Biol. 2006 Jul;13(7):626-32. Epub 2006 Jun 25. PMID:16799558 doi:10.1038/nsmb1113
