6jn2
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10== | |
| + | <StructureSection load='6jn2' size='340' side='right'caption='[[6jn2]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6jn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JN2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jn2 OCA], [https://pdbe.org/6jn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jn2 RCSB], [https://www.ebi.ac.uk/pdbsum/6jn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jn2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN] Precursor T-cell acute lymphoblastic leukemia. A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein. A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AF10_HUMAN AF10_HUMAN] Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.<ref>PMID:17868029</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Song X]] | ||
| + | [[Category: Wang M]] | ||
| + | [[Category: Xu RM]] | ||
| + | [[Category: Yang N]] | ||
Current revision
Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10
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Categories: Homo sapiens | Large Structures | Song X | Wang M | Xu RM | Yang N
