6o0r

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'''Unreleased structure'''
 
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The entry 6o0r is ON HOLD until Paper Publication
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==Crystal structure of the TIR domain from human SARM1 in complex with glycerol==
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<StructureSection load='6o0r' size='340' side='right'caption='[[6o0r]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6o0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O0R FirstGlance]. <br>
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Description: Crystal structure of the TIR domain from human SARM1 in complex with glycerol
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Kobe, B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o0r OCA], [https://pdbe.org/6o0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o0r RCSB], [https://www.ebi.ac.uk/pdbsum/6o0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o0r ProSAT]</span></td></tr>
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[[Category: Ve, T]]
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</table>
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[[Category: Ericsson, D.J]]
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== Function ==
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[[Category: Chen, J]]
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[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
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[[Category: Casey, L]]
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== References ==
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[[Category: Manik, M.K]]
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<references/>
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[[Category: Nanson, J.D]]
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__TOC__
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[[Category: Foley, G]]
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</StructureSection>
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[[Category: Zhang, X]]
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[[Category: Homo sapiens]]
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[[Category: Tiancong, Q]]
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[[Category: Large Structures]]
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[[Category: Lai, J]]
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[[Category: Boden M]]
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[[Category: Williams, S.J]]
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[[Category: Bosanac T]]
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[[Category: Dry, I.B]]
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[[Category: Burdett H]]
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[[Category: Burdett, H]]
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[[Category: Casey L]]
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[[Category: Rathjen, J.P]]
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[[Category: Chen J]]
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[[Category: Horsefield, S]]
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[[Category: Coleman MP]]
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[[Category: Dodds, P.N]]
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[[Category: Deerain N]]
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[[Category: Boden, M]]
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[[Category: Dodds PN]]
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[[Category: Von Itzstein, M]]
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[[Category: Dry IB]]
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[[Category: Deerain, N]]
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[[Category: Ericsson DJ]]
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[[Category: Hughes, R.O]]
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[[Category: Foley G]]
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[[Category: Coleman, M.P]]
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[[Category: Gilley J]]
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[[Category: Bosanac, T]]
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[[Category: Gu W]]
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[[Category: Shi, Y]]
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[[Category: Horsefield S]]
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[[Category: Gilley, J]]
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[[Category: Hughes RO]]
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[[Category: Gu, W]]
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[[Category: Kobe B]]
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[[Category: Rank, M]]
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[[Category: Lai J]]
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[[Category: Staskawicz, B.J]]
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[[Category: Manik MK]]
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[[Category: Nanson JD]]
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[[Category: Rank M]]
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[[Category: Rathjen JP]]
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[[Category: Shi Y]]
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[[Category: Staskawicz BJ]]
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[[Category: Tiancong Q]]
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[[Category: Ve T]]
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[[Category: Williams SJ]]
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[[Category: Zhang X]]
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[[Category: Von Itzstein M]]

Current revision

Crystal structure of the TIR domain from human SARM1 in complex with glycerol

PDB ID 6o0r

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OCA

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