6o0w

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'''Unreleased structure'''
 
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The entry 6o0w is ON HOLD until Paper Publication
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==Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris==
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<StructureSection load='6o0w' size='340' side='right'caption='[[6o0w]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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Authors: Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6o0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vitis_rotundifolia Vitis rotundifolia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O0W FirstGlance]. <br>
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Description: Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2P:ADENOSINE-2-5-DIPHOSPHATE'>A2P</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene></td></tr>
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[[Category: Kobe, B]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o0w OCA], [https://pdbe.org/6o0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o0w RCSB], [https://www.ebi.ac.uk/pdbsum/6o0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o0w ProSAT]</span></td></tr>
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[[Category: Ve, T]]
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</table>
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[[Category: Ericsson, D.J]]
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== Function ==
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[[Category: Chen, J]]
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[https://www.uniprot.org/uniprot/RUN1_VITRO RUN1_VITRO] Disease resistance (R) protein that confers resistance to multiple powdery and downy mildew by promoting cell death (PubMed:24033846, PubMed:31439792). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:31439792).<ref>PMID:24033846</ref> <ref>PMID:31439792</ref>
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[[Category: Casey, L]]
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== References ==
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[[Category: Manik, M.K]]
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<references/>
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[[Category: Nanson, J.D]]
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__TOC__
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[[Category: Foley, G]]
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</StructureSection>
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[[Category: Zhang, X]]
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[[Category: Large Structures]]
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[[Category: Tiancong, Q]]
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[[Category: Vitis rotundifolia]]
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[[Category: Lai, J]]
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[[Category: Boden M]]
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[[Category: Williams, S.J]]
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[[Category: Bosanac T]]
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[[Category: Dry, I.B]]
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[[Category: Burdett H]]
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[[Category: Burdett, H]]
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[[Category: Casey L]]
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[[Category: Rathjen, J.P]]
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[[Category: Chen J]]
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[[Category: Horsefield, S]]
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[[Category: Coleman MP]]
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[[Category: Dodds, P.N]]
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[[Category: Dodds PN]]
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[[Category: Boden, M]]
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[[Category: Dry IB]]
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[[Category: Von Itzstein, M]]
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[[Category: Ericsson DJ]]
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[[Category: Hughes, R.O]]
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[[Category: Foley G]]
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[[Category: Coleman, M.P]]
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[[Category: Gilley J]]
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[[Category: Bosanac, T]]
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[[Category: Gu W]]
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[[Category: Rank, M]]
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[[Category: Horsefield S]]
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[[Category: Gu, W]]
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[[Category: Hughes RO]]
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[[Category: Gilley, J]]
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[[Category: Kobe B]]
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[[Category: Shi, Y]]
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[[Category: Lai J]]
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[[Category: Staskawicz, B.J]]
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[[Category: Manik MK]]
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[[Category: Nanson JD]]
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[[Category: Rank M]]
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[[Category: Rathjen JP]]
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[[Category: Shi Y]]
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[[Category: Staskawicz BJ]]
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[[Category: Tiancong Q]]
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[[Category: Ve T]]
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[[Category: Williams SJ]]
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[[Category: Zhang X]]
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[[Category: Von Itzstein M]]

Current revision

Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 in complex with NADP+ and Bis-Tris

PDB ID 6o0w

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