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6ob1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of WHB in complex with Ubiquitin Variant== | |
| + | <StructureSection load='6ob1' size='340' side='right'caption='[[6ob1]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ob1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OB1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ob1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ob1 OCA], [https://pdbe.org/6ob1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ob1 RCSB], [https://www.ebi.ac.uk/pdbsum/6ob1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ob1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ANC2_HUMAN ANC2_HUMAN] Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[3D structures of ubiquitin|3D structures of ubiquitin]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Edmond RW]] | ||
| + | [[Category: Grace CR]] | ||
Current revision
Structure of WHB in complex with Ubiquitin Variant
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