6r3e

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(New page: '''Unreleased structure''' The entry 6r3e is ON HOLD Authors: Rondelet, G., Dal Maso, T., Wouters, J. Description: Human DNMT3B PWWP domain in complex with triisopropanolamine [[Catego...)
Current revision (12:14, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6r3e is ON HOLD
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==Human DNMT3B PWWP domain in complex with triisopropanolamine==
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<StructureSection load='6r3e' size='340' side='right'caption='[[6r3e]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6r3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R3E FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.269&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=96H:Triisopropanolamine'>96H</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3e OCA], [https://pdbe.org/6r3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r3e RCSB], [https://www.ebi.ac.uk/pdbsum/6r3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3e ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
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Authors: Rondelet, G., Dal Maso, T., Wouters, J.
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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Description: Human DNMT3B PWWP domain in complex with triisopropanolamine
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Wouters, J]]
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__TOC__
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[[Category: Rondelet, G]]
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</StructureSection>
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[[Category: Dal Maso, T]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dal Maso T]]
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[[Category: Rondelet G]]
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[[Category: Wouters J]]

Current revision

Human DNMT3B PWWP domain in complex with triisopropanolamine

PDB ID 6r3e

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