6i5z
From Proteopedia
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<StructureSection load='6i5z' size='340' side='right'caption='[[6i5z]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='6i5z' size='340' side='right'caption='[[6i5z]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6i5z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5Z OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6i5z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Papaver_somniferum Papaver somniferum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I5Z FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i5z OCA], [https://pdbe.org/6i5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i5z RCSB], [https://www.ebi.ac.uk/pdbsum/6i5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i5z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SOMT1_PAPSO SOMT1_PAPSO] Methyltransferase involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:22535422, PubMed:22653730, PubMed:29610307). Catalyzes the conversion of (S)-scoulerine to (S)-tetrahydrocolumbamine (PubMed:22535422, PubMed:22653730). Can convert (S)-tetrahydrocolumbamine to tetrahydropalmatine (PubMed:22535422). Can convert (S)-norreticuline to (S)-norcodamine (PubMed:22535422). Can convert (S)-reticuline to (S)-codamine (PubMed:22535422). Substrate preference is (S)-scoulerine > (S)-tetrahydrocolumbamine > (S)-norreticuline > (S)-reticuline (PubMed:22535422).<ref>PMID:22535422</ref> <ref>PMID:22653730</ref> <ref>PMID:29610307</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Cabry, M P]] | ||
| - | [[Category: Davies, G J]] | ||
| - | [[Category: Offen, W A]] | ||
[[Category: Papaver somniferum]] | [[Category: Papaver somniferum]] | ||
| - | [[Category: | + | [[Category: Cabry MP]] |
| - | [[Category: | + | [[Category: Davies GJ]] |
| - | [[Category: | + | [[Category: Offen WA]] |
Current revision
Papaver somniferum O-methyltransferase
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