2x9e

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:37, 16 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='2x9e' size='340' side='right'caption='[[2x9e]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
<StructureSection load='2x9e' size='340' side='right'caption='[[2x9e]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2x9e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X9E FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2x9e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X9E FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SVE:N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>SVE</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hmo|3hmo]], [[3hmp|3hmp]], [[3h9f|3h9f]], [[3hmn|3hmn]], [[3gfw|3gfw]], [[2zmc|2zmc]], [[3cek|3cek]], [[2zmd|2zmd]], [[3dbq|3dbq]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SVE:N-(2,6-DIETHYLPHENYL)-1-METHYL-8-({4-[(1-METHYLPIPERIDIN-4-YL)CARBAMOYL]-2-(TRIFLUOROMETHOXY)PHENYL}AMINO)-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE'>SVE</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9e OCA], [https://pdbe.org/2x9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x9e RCSB], [https://www.ebi.ac.uk/pdbsum/2x9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9e ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9e OCA], [http://pdbe.org/2x9e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x9e RCSB], [http://www.ebi.ac.uk/pdbsum/2x9e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9e ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
+
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 22:
==See Also==
==See Also==
*[[Dual specificity protein kinase|Dual specificity protein kinase]]
*[[Dual specificity protein kinase|Dual specificity protein kinase]]
 +
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Dual-specificity kinase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Avanzi, N]]
+
[[Category: Avanzi N]]
-
[[Category: Bertrand, J A]]
+
[[Category: Bertrand JA]]
-
[[Category: Bossi, R T]]
+
[[Category: Bossi RT]]
-
[[Category: Caldarelli, M]]
+
[[Category: Caldarelli M]]
-
[[Category: Cappella, P]]
+
[[Category: Cappella P]]
-
[[Category: Colombo, R]]
+
[[Category: Colombo R]]
-
[[Category: Colotta, F]]
+
[[Category: Colotta F]]
-
[[Category: Cucchi, U]]
+
[[Category: Cucchi U]]
-
[[Category: DePaolini, S R]]
+
[[Category: DePaolini SR]]
-
[[Category: Donati, D]]
+
[[Category: Donati D]]
-
[[Category: Galvani, A]]
+
[[Category: Galvani A]]
-
[[Category: Giorgini, M L]]
+
[[Category: Giorgini ML]]
-
[[Category: Isacchi, A]]
+
[[Category: Isacchi A]]
-
[[Category: Mennecozzi, M]]
+
[[Category: Mennecozzi M]]
-
[[Category: Moll, J]]
+
[[Category: Moll J]]
-
[[Category: Perrera, C]]
+
[[Category: Perrera C]]
-
[[Category: Pesenti, E]]
+
[[Category: Pesenti E]]
-
[[Category: Rusconi, L]]
+
[[Category: Rusconi L]]
-
[[Category: Sola, F]]
+
[[Category: Sola F]]
-
[[Category: Kinase]]
+
-
[[Category: Mitotic checkpoint]]
+
-
[[Category: Serine/threonine-protein kinase]]
+
-
[[Category: Transferase]]
+
-
[[Category: Tyrosine-protein kinase]]
+

Current revision

HUMAN MPS1 IN COMPLEX WITH NMS-P715

PDB ID 2x9e

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2x9e"
Personal tools