4gal

<table><tr><td colspan='2'>[[4gal]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GAL FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gal OCA], [http://pdbe.org/4gal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gal RCSB], [http://www.ebi.ac.uk/pdbsum/4gal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gal ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Knowledge about carbohydrate recognition domains of galectins, formerly known as S-type animal lectins, is important in understanding their role(s) in cell-cell interactions. Here we report the crystal structure of human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This is the first structure of a galectin determined in both free and carbohydrate-bound forms. The structure shows a fold similar to that of the prototype galectins -1 and -2, but has greater similarity to a related galectin molecule, Gal-10. Even though the carbohydrate-binding residues are conserved, there are significant changes in this pocket due to shortening of a loop structure. The monomeric hGal-7 molecule exists as a dimer in the crystals, but adopts a packing arrangement considerably different from that of Gal-1 and Gal-2, which has implications for carbohydrate recognition.

Structural basis for the recognition of carbohydrates by human galectin-7.,Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:9760227<ref>PMID:9760227</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4gal" style="background-color:#fffaf0;"></div>

*[[Galectin|Galectin]]

[[Category: Human]]

[[Category: Acharya, K R]]

[[Category: Leonidas, D D]]

[[Category: Lectin]]