4iuy
From Proteopedia
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<StructureSection load='4iuy' size='340' side='right'caption='[[4iuy]], [[Resolution|resolution]] 2.38Å' scene=''> | <StructureSection load='4iuy' size='340' side='right'caption='[[4iuy]], [[Resolution|resolution]] 2.38Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4iuy]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4iuy]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii_ACICU Acinetobacter baumannii ACICU]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUY FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.385Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iuy OCA], [https://pdbe.org/4iuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iuy RCSB], [https://www.ebi.ac.uk/pdbsum/4iuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iuy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Over 15% of the genome of an Australian clinical isolate of Acinetobacter baumannii occurs within genomic islands. An uncharacterized protein encoded within one island feature common to this and other International Clone II strains has been studied by X-ray crystallography. The 2.4 A resolution structure of SDR-WM99c reveals it to be a new member of the classical short-chain dehydrogenase/reductase (SDR) superfamily. The enzyme contains a nucleotide-binding domain and, like many other SDRs, is tetrameric in form. The active site contains a catalytic tetrad (Asn117, Ser146, Tyr159 and Lys163) and water molecules occupying the presumed NADP cofactor-binding pocket. An adjacent cleft is capped by a relatively mobile helical subdomain, which is well positioned to control substrate access. | ||
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| + | Structure of a short-chain dehydrogenase/reductase (SDR) within a genomic island from a clinical strain of Acinetobacter baumannii.,Shah BS, Tetu SG, Harrop SJ, Paulsen IT, Mabbutt BC Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1318-23. doi:, 10.1107/S2053230X14019785. Epub 2014 Sep 25. PMID:25286932<ref>PMID:25286932</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4iuy" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Acinetobacter baumannii ACICU]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Harrop | + | [[Category: Harrop SJ]] |
| - | [[Category: Mabbutt | + | [[Category: Mabbutt BC]] |
| - | [[Category: Paulsen | + | [[Category: Paulsen IT]] |
| - | [[Category: Shah | + | [[Category: Shah BS]] |
| - | [[Category: Tetu | + | [[Category: Tetu SG]] |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of short-chain dehydrogenase/reductase (apo-form) from A. baumannii clinical strain WM99C
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