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4g6a

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<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4g6a' size='340' side='right'caption='[[4g6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G6A FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [http://pdbe.org/4g6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [http://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g6a OCA], [https://pdbe.org/4g6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g6a RCSB], [https://www.ebi.ac.uk/pdbsum/4g6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g6a ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9YK84_9HEPC Q9YK84_9HEPC]
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We have determined the crystal structure of broadly neutralizing antibody (bnAb) AP33 bound to a peptide corresponding to hepatitis C virus (HCV) E2 envelope glycoprotein antigenic site 412-423. Comparison with bnAb HCV1 bound to the same epitope reveals a different angle of approach to the antigen by bnAb AP33, and slight variation in its beta-hairpin conformation of the epitope. These structures establish two different modes of binding to E2 that antibodies adopt to neutralize diverse HCV.
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Structure of hepatitis C virus envelope glycoprotein E2 antigenic site 412-423 in complex with antibody AP33.,Kong L, Giang E, Nieusma T, Robbins JB, Deller MC, Stanfield RL, Wilson IA, Law M J Virol. 2012 Sep 12. PMID:22973046<ref>PMID:22973046</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4g6a" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Hepacivirus C]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kong, L]]
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[[Category: Kong L]]
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[[Category: Law, M]]
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[[Category: Law M]]
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[[Category: Wilson, I A]]
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[[Category: Wilson IA]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin fold]]
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Current revision

Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33

PDB ID 4g6a

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OCA

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