Geranylgeranyl transferase
From Proteopedia
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== Function == | == Function == | ||
| - | '''Geranylgeranyl transferase''' type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins | + | '''Geranylgeranyl transferase''' '''type 1''' (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containing the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid). '''Geranylgeranyl transferase type 2''' (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein. The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated<ref>PMID:16477080</ref>. |
== Relevance == | == Relevance == | ||
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The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres. | The <scene name='59/597443/Cv/5'>active site with bound geranylgeranyl pyrophosphate</scene> contains a <scene name='59/597443/Cv/6'>Zn+2 atom</scene><ref>PMID:18756270</ref>. Water molecules shown as red spheres. | ||
| - | </StructureSection> | ||
| - | ==3D structures of | + | ==3D structures of geranylgeranyl transferase== |
| + | [[Geranylgeranyl transferase 3D structures]] | ||
| - | + | </StructureSection> | |
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| - | **[[3c72]], [[3pz1]], [[3pz3]], [[4ehm]], [[4gts]], [[4gtt]], [[4gtv]] – rGGT2 α+β subunits + inhibitor<br /> | ||
| - | **[[3hxb]], [[3hxc]], [[3hxd]], [[3hxe]], [[3hxf]] – rGGT2 α (mutant) +β subunits + inhibitor<br /> | ||
| - | **[[1ltx]] – rGGT α+β subunits + tetra-alanine + Rab escort protein + farnesyl<br /> | ||
| - | **[[3dst]] – rGGT2 α+β subunits + GGPP<br /> | ||
| - | **[[3dsu]] – rGGT2 α+β subunits + farnesyl-PP<br /> | ||
| - | **[[3dsv]], [[3dsw]], [[3dsx]] – rGGT2 α+β subunits + GG<br /> | ||
| - | **[[3pz2]] – rGGT2 α+β subunits + GGPP + inhibitor<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Lane KT, Beese LS. Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. J Lipid Res. 2006 Apr;47(4):681-99. Epub 2006 Feb 13. PMID:16477080 doi:http://dx.doi.org/10.1194/jlr.R600002-JLR200
- ↑ Lawson MA, Coulton L, Ebetino FH, Vanderkerken K, Croucher PI. Geranylgeranyl transferase type II inhibition prevents myeloma bone disease. Biochem Biophys Res Commun. 2008 Dec 12;377(2):453-7. doi:, 10.1016/j.bbrc.2008.09.157. Epub 2008 Oct 16. PMID:18929536 doi:http://dx.doi.org/10.1016/j.bbrc.2008.09.157
- ↑ Guo Z, Wu YW, Das D, Delon C, Cramer J, Yu S, Thuns S, Lupilova N, Waldmann H, Brunsveld L, Goody RS, Alexandrov K, Blankenfeldt W. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. EMBO J. 2008 Sep 17;27(18):2444-56. Epub 2008 Aug 28. PMID:18756270 doi:10.1038/emboj.2008.164
