Baculoviral IAP repeat-containing protein

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Human Baculoviral IAP repeat-containing protein 2 BIR3 domain (magenta) complex with caspase-9 peptide (green) and Zn+2 ion (PDB code 3d9t)

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1 Function
2 Disease
3 Relevance
4 Structural highlights
5 3D Structures of Baculoviral IAP repeat-containing protein

Function

IAPs were discovered in baculoviruses and were shown to be involved in suppressing the host cell response to viral infection. ^[1]

Baculoviral IAP repeat-containing protein 1 (BIRC1 or NAIP) inhibits the activities of caspase-3,7,9. BIRC1 acts as mediator of neuronal survival in pathological conditions and prevents motor-neuron apoptosis.
Baculoviral IAP repeat-containing protein 2 (cIAP1) and Baculoviral IAP repeat-containing protein 3 (cIAP2) inhibit apoptosis by interfering with the activation of caspase and by binding to TNFR-associated factors TRAF1 and TRAF2. cIAP1 is a multi-functional protein which acts as an E3 ubiquitin-protein ligase and plays a role in the modulation of the cell cycle. cIAP1 is involved in controlling b-cell survival under ER stress caused by lipotoxicity. Both cIAP1 and cIAP2 regulate NF-kB activation. cIAP2 inhibits apoptosis caused by serum deprivation but not by inducers of free radicals.
For Baculoviral IAP repeat-containing protein 4 see XIAP in Ubiquitin protein ligase.
For Baculoviral IAP repeat-containing protein 5 see Survivin.
Baculoviral IAP repeat-containing protein 6 (BIRC6) inhibits caspase-3,7,9. Has a role in the final stages of cytokinesis, vescilcle targeting to the site of abscission and ubiquitin conjugation.
Baculoviral IAP repeat-containing protein 7 or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.
Baculoviral IAP repeat-containing protein 8 (BIRC8).

Disease

cIAP1 is a target for intervention against type 2 diabetes. Mutated or deleted BIRC1 were found in individuals with severe muscular atrophy.

Relevance

IAP proteins suppress cell death by inhibiting the activity of caspases. As they are involved in apoptosis regulation, IAPs are of interest in cancer and autoimmune diseases therapy.

Structural highlights

cIAPs domains include 3 BIR (zinc-finger found in apoptosis inhibitors) domains in the N-terminal, a UBA (Ubiquitin-Associated), CARD (Caspase Recruitment) and RING finger (zinc finger which contains Cys3-His-Cys4 motif) domain in the C-terminal.

in human Baculoviral IAP repeat-containing protein 2 BIR3 domain (PDB code 3d9t)^[2]

3D Structures of Baculoviral IAP repeat-containing protein

Baculoviral IAP repeat-containing protein 3D structures

References

↑ Deveraux QL, Reed JC. IAP family proteins--suppressors of apoptosis. Genes Dev. 1999 Feb 1;13(3):239-52. PMID:9990849
↑ Raina D, Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R, Kufe D. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem. 2005 Mar 25;280(12):11147-51. Epub 2005 Jan 18. PMID:15657060 doi:10.1074/jbc.M413787200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Baculoviral_IAP_repeat-containing_protein"

Category: Topic Page

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 </StructureSection>
-== 3D Structures of Baculoviral IAP repeat-containing protein ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Baculoviral IAP repeat-containing protein 1 (BIRC1)
-**[[2vm5]] – hBIRC1 BIR2 domain – human<br />
-**[[6b5b]] – mBIRC1e + NLRC4 + flagellin – mouse – Cryo EM<br />
-**[[5yud]] – mBIRC1e + flagellin – Cryo EM<br />
-*Baculoviral IAP repeat-containing protein 2 (cIAP1)); domains: BIR1 40-119; BIR3 266-363; CARD 435-562; RING 562-618
-**[[3m1d]] – hcIAP1 BIR1 domain <br />
-**[[1qbh]] – hcIAP1 BIR3 domain – NMR<br />
-**[[2l9m]] – hcIAP1 CARD domain – NMR<br />
-**[[3t6p]] – hcIAP1 BIR3-RING domain (mutant)<br />
-*cIAP1 complex
-**[[3d9t]] – hcIAP1 BIR3 domain + caspase-9 peptide<br />
-**[[3d9u]] – hcIAP1 BIR3 domain + SMAC/DIABLO peptide<br />
-**[[3mup]], [[3oz1]], [[4eb9]] – hcIAP1 BIR3 domain + SMAC-mimetic<br />
-**[[3uw4]] – hcIAP1 BIR3 domain (mutant) + anti-cancer peptide<br />
-**[[6exw]] – hcIAP1 BIR3 domain (mutant) + azepine derivative<br />
-**[[4hy4]], [[4hy5]], [[4lge]], [[4lgu]], [[4mti]], [[4mu7]], [[4kmn]], [[5m6n]] – hcIAP1 BIR3 domain + inhibitor<br />
-**[[6hpr]] – hcIAP1 RING domain + polyubiquitin + E2 ubiquitin-conjugating enzyme<br />
-*Baculoviral IAP repeat-containing protein 3 (cIAP2)
-**[[3eb5]] – hcIAP2 RING domain<br />
-**[[2uvl]] – hcIAP2 BIR3 domain <br />
-*cIAP2 complex
-**[[3eb6]] – hcIAP2 RING domain + ubiquitin-conjugating enzyme E2<br />
-**[[3m0d]] – hcIAP2 BIR1 domain + TNF-associated factor 1 + TNF-associated factor 2 <br />
-**[[3m0a]] – hcIAP2 BIR1 domain + TNF-associated factor 2 <br />
-*Baculoviral IAP repeat-containing protein 4 see [[E3 ubiquitin-protein ligase]]
-*Baculoviral IAP repeat-containing protein 5 see [[Survivin]]
-*Baculoviral IAP repeat-containing protein 6 (BIRC6)
-**[[3ceg]] – hBIRC6 UBA domain <br />
-*Baculoviral IAP repeat-containing protein 7 (ML-IAP)
-**[[1oxn]], [[1oy7]] – hML-IAP BIR domain + peptide inhibitor<br />
-**[[1oxq]] – hML-IAP BIR domain + SMAC peptide inhibitor<br />
-**[[1tw6]], [[2i3h]] – hML-IAP/XIAP BIR domain (mutant) + SMAC peptide inhibitor<br />
-**[[2i3i]], [[3f7g]], [[3f7h]], [[3f7i]], [[3gt9]], [[3gta]] – hML-IAP/XIAP BIR domain (mutant) + peptidomimetic<br />
-**[[3uw5]] – hML-IAP/XIAP BIR domain (mutant) + anti-cancer peptidomimetic<br />
-**[[4auq]] – hML-IAP residues 239-298 + ubiquitin-conjugating enzyme E2 + ubiquitin<br />
-*Baculoviral IAP repeat-containing protein 8 (BIRC8)
-**[[1xb0]], [[1xb1]] – hBIRC8 BIR domain + DIABLO
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]

Baculoviral IAP repeat-containing protein

From Proteopedia

Current revision

Contents

Function

Disease

Relevance

Structural highlights

3D Structures of Baculoviral IAP repeat-containing protein

References

Proteopedia Page Contributors and Editors (what is this?)

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