Glutathione S-transferase

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== Function ==
== Function ==
'''Glutathione S-transferase''' (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal<ref>PMID:21428697</ref>.
'''Glutathione S-transferase''' (GST) catalyzes the conjugation of reduced glutathione (GSH) to a variety of exogenous and endogenous hydrophobic electrophiles. For example, GST can detoxify peroxidised lipids. All eukaryotes possess a variety of GSTs with catalytic and non-catalytic activities. GST is divided into classes: α, δ, ε, κ, μ, ν, ω, π, ρ, σ (hematopoietic prostaglandin D synthase), τ, χ, ϑ, ζ and microsomal<ref>PMID:21428697</ref>.
 +
*'''epsilon glutathione S-transferase''' has a role in insecticide resistance<ref>PMID:26487708</ref>.
 +
*'''kappa glutathione S-transferase''' is found in mitochondria and peroxisomes. It may be involved in lipid metabolism<ref>PMID:21428694</ref>.
 +
*'''mu glutathione S-transferase''' detoxify carcinogens in tobacco smoke<ref>PMID:8485718</ref>.
 +
*'''nu glutathione S-transferase''' breaks the beta-aryl ether bond of lignin<ref>PMID:29449375</ref>.
 +
*'''pi glutathione S-transferase''' has a role in carcinogenic processes<ref>PMID:9679544</ref>.
 +
*'''rho glutathione S-transferase''' detoxifies water from the pollutant dichloroacetate<ref>PMID:25685659</ref>.
 +
*'''sigma glutathione S-transferase''' is a detoxifying agent providing drug resistance and acting as vaccine antigen<ref>PMID:38668546</ref>.
 +
*'''omega glutathione S-transferase''' catalyzes a range of thiol transferase reactions like biotransformation of haloketones to nontoxic acetophenones<ref>PMID:21495794</ref>.
 +
*'''zeta glutathione S-transferase''' catalyzes the reaction of glutathione with Endo- and xenobiotics<ref>PMID:21303221</ref>.
 +
*'''tau glutathione S-transferase''' and '''LanCL1 glutathione S-transferase''' are involved in oxidative stress response<ref>PMID:15037622</ref>.
 +
*'''phi glutathione S-transferase''' is plant-specific<ref>PMID:26884677</ref>.
 +
*'''microsomali glutathione S-transferase''' protects cells from cytostatic drugs and from oxidative stress<ref>PMID:21495795</ref>.
==Relevance==
==Relevance==
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== Structural highlights ==
== Structural highlights ==
The <scene name='52/524296/Cv/4'>glutathione binding site is at the N-terminal of GST</scene><ref>PMID:9367777</ref>.
The <scene name='52/524296/Cv/4'>glutathione binding site is at the N-terminal of GST</scene><ref>PMID:9367777</ref>.
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</StructureSection>
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==3D structures of glutathione S-transferase==
==3D structures of glutathione S-transferase==
 +
[[Glutathione S-transferase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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-
 
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-
*GST
+
-
 
+
-
**[[4hz4]] – GST – ''Actinobacillus pleuropneumoniae''<br />
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-
**[[1gsb]], [[1gsc]] – rGST – rat<br />
+
-
**[[3ubk]] – LiGST – ''Leptospira interrogans''<br />
+
-
**[[3uap]] - McGST – ''Methylococcus capsulatus''<br />
+
-
**[[1aw9]] - cGST III – corn<br />
+
-
**[[1okt]], [[4zxg]] – PfGST – ''Plasmodium falciparum''<br />
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**[[3fr6]] - PfGST (mutant) <br />
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-
**[[1tw9]] – GST - ''Heligmosomoides polygyrus''<br />
+
-
**[[1yq1]] - CeGST – ''Caenorhabditis elegans''<br />
+
-
**[[1y6e]] - SjGST – ''Schistosoma japonicum''<br />
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-
**[[2fno]], [[3lq7]] - AtGST – ''Agrobacterium tumefaciens''<br />
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-
**[[2on7]] – NaGST-1 – ''Necator americanus''<br />
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-
**[[3erf]] - yGST II – yeast<br />
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**[[3f6f]] – DmGST – ''Drosophila melanogaster''<br />
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-
**[[3lxt]] - PsfGST – ''Pseudomonas fluorescens''<br />
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**[[4eci]] - PaGST – ''Pseudomonas aeruginosa''<br />
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-
**[[3niv]] - GST – ''Legionella pneumophila''<br />
+
-
**[[3tot]] - RsGST – ''Ralstonia solanacearum''<br />
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-
**[[3ay8]], [[4e8e]] - siGST – silkworm<br />
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-
**[[1jlw]] - AcGST - ''Anopheles cracens''<br />
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-
**[[4f03]] - PcGST - ''Phanerochaete chrysosporium''<br />
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-
**[[3vwx]] – GST 6B (mutant) – fly<br />
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-
**[[3w8s]] – hoGST 3 – hookworm<br />
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-
**[[4ofm]], [[4ofn]], [[4oft]] – hoGST 1<br />
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-
**[[4j2f]] – GST – castor bean<br />
+
-
**[[4mp4]] – GST – ''Acinetobacter baumannii''<br />
+
-
**[[4o7h]] – GST – ''Rhodospirillum rubrum''<br />
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-
**[[4o92]] – GST – ''Pichia kudriavzevii''<br />
+
-
**[[4mf7]] – GST – ''Bradyrhizobium''<br />
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-
**[[4n0v]] – GST N terminal – ''Marinobacter aquaeolei''<br />
+
-
**[[4pts]] – GST – ''Gordonia bronchialis''<br />
+
-
**[[5el8]], [[5ela]], [[5elg]] - AtGST DHAR1 – ''Arabidopsis thaliana''<br />
+
-
 
+
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*''GST binary complex with GSH''
+
-
 
+
-
**[[2x64]] – GST + GSH – ''Xylella fastidiosa''<br />
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-
**[[4hz2]] - GST + GSH - ''Xanthobacter autotrophicus''<br />
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-
**[[4ecj]] - PaGST + GSH<BR />
+
-
**[[1fhe]], [[2fhe]] - FhGST + GSH – ''Fasciola hepatica''<br />
+
-
**[[1pmt]], [[2pmt]] - GST + GSH – ''Proteus mirabilis''<br />
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-
**[[1m0u]], [[3gh6]] - DmGST + GSH<BR />
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-
**[[1oe7]], [[1oe8]] - ShGST + GSH – ''Schistosoma haematobium''<br />
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-
**[[1u3i]] - GST + GSH - ''Schistosoma mansoni''<br />
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-
**[[1oyj]] - GST + GSH - rice<br />
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-
**[[1u87]], [[1gne]] - SjGST + GSH<BR />
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-
**[[2dsa]], [[2gdr]] - GST + GSH – ''Burkholderia xenovorans''<br />
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-
**[[4isd]] - GST + GSH – ''Burkholderia glumae''<br />
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-
**[[2on5]] – NaGST-2 + GSH<BR />
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-
**[[2nto]] - OaGST + GSH – ''Ochrobactrum anthropi''<br />
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-
**[[2pvq]] - OaGST (mutant) + GSH<BR />
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**[[3ibh]] - yGST II + GSH<BR />
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-
**[[3fr9]] - PfGST + GSH<BR />
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**[[3m3m]] - PsfGST + GSH<BR />
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-
**[[3lsz]] - GST + GSH – ''Rhodobacter sphaeroides''<br />
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-
**[[3n5o]] - GST + GSH – ''Coccidioides immitis''<br />
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-
**[[3tou]], [[4kf9]] - RsGST + GSH<BR />
+
-
**[[3uar]] - McGST + GSH<BR />
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-
**[[4g9h]], [[4gci]] - GST + GSH – ''Yersinia pestis''<br />
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-
**[[4gf0]] - GST + GSH - ''Sulfitobacter''<br />
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-
**[[1jlv]] - AcGST + GSH<br />
+
-
**[[4g19]] - PcGST + GSH<br />
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-
**[[4ikh]] – GST + GSH – ''Pseudomonas protegens''<br />
+
-
**[[4jed]] – GST + GSH – ''Methylobacter radiotolerans''<br />
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-
**[[4kgi]] – GST + GSH – ''Shigella flexneri''<br />
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**[[4kh7]] – GST + GSH – ''Salmonella enterica''<br />
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**[[4mk3]] – GST + GSH derivative – ''Cupriavidus metallidurans''<br />
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**[[4nhw]] – GST + GSH – ''Sinorhizobium meliloti''<br />
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-
**[[4l8e]] – GST + GSH – ''Xenorhabdus nematophila''<br />
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**[[4nax]] – GST N terminal + GSH – ''Pseudomonas putida''<br />
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**[[4pua]] – GST + GSH – ''Streptococcus pneumoniae''<br />
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-
**[[5an1]] – GST + GSH – shrimp<br />
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-
**[[5lol]] - AtGST DHAR2 + GSH<br />
+
-
 
+
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*''GST binary complex''
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+
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**[[3ubl]] - LiGST + GSH derivative<br />
+
-
**[[2gsq]] – sqGST + GSH derivative – squid<br />
+
-
**[[2gst]], [[3gst]], [[4gst]], [[5gst]], [[1gss]] - rGST + GSH derivative<br />
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-
**[[1gnw]] - AtGST + GSH derivative <br />
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**[[5a4u]] - AtGST + indole aldehyde<br />
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**[[5a4v]], [[5a4w]] - AtGST + quercetin<br />
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**[[5a5k]] - AtGST + camalexin<br />
+
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**[[1aqv]] - hGST + GSH derivative – human<br />
+
-
**[[1gtb]], [[1gta]] - SjGST + praziquantel<br />
+
-
**[[1m99]], [[1m9a]], [[1m9b]] - SjGST + GSH derivative<br />
+
-
**[[1q4j]], [[2aaw]], [[3frc]] - PfGST + GSH derivative<br />
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**[[3fr3]] - PfGST (mutant) + GSH derivative<br />
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**[[1bx9]] - AtGST + herbicide<br />
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**[[1bye]] - cGST I + herbicide <br />
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**[[1axd]] – cGST I + lactoyl-GSH<BR />
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**[[1a0f]], [[1n2a]] - GST + GSH derivative – ''Eschericia coli''<br />
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**[[1f2e]] - GST + GSH derivative – ''Sphingomonas paucimobilis''<br />
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**[[1mtc]] - rGST + GSH derivative<br />
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-
**[[1ua5]] - SjGST + GSH derivative<br />
+
-
**[[1u88]] - SjGST (mutant) + GSH derivative<br />
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-
**[[3erg]] - yGST II + GSH derivative<br />
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**[[3qmz]] - yGST + dynein heavy chain<br />
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**[[2ycd]] - AtGST + GSH derivative<br />
+
-
**[[4yav]] - GST + GSH derivative – ''Sphingobium''<br />
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-
 
+
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*GST α class
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+
-
**[[1guh]], [[1gsd]], [[1k3o]], [[1pkz]] – hGST A1-1<br />
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-
**[[1xwg]], [[3q74]], [[3u6v]], [[3zfb]], [[3zfl]] - hGST A1-1 (mutant) <br />
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-
**[[1gum]] - hGST A4-4<br />
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**[[1guk]] - mGST A4-4 – mouse<br />
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**[[1vf4]] - GgGST A1-1 - chicken
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+
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*''GST α class complex with GSH''
+
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+
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**[[1pkw]] - hGST + GSH<BR />
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**[[1usb]] - hGST (mutant) + GSH<BR />
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**[[1f3a]] - mGST A1-1+ GSH<BR />
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-
**[[3i69]], [[3i6a]] - hGST A1-1 (mutant)+ GSH<BR />
+
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**[[2wju]] - hGST A2-2 + GSH<BR />
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**[[4acs]] - hGST A2-2 (mutant) + GSH<BR />
+
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**[[1tdi]] - hGST A3-3 + GSH<BR />
+
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**[[1vf1]] - GgGST A1-1 + GSH<BR />
+
-
 
+
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*''GST α class complex''
+
-
 
+
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**[[1gsf]] – hGST A1-1 + ethacrynic acid<br />
+
-
**[[1ags]], [[1pl2]], [[1ydk]], [[2r3x]], [[2r6k]], [[3ktl]], [[3l0h]] – hGST (mutant) + GSH derivative<br />
+
-
**[[1k3l]], [[1k3y]], [[1pl1]] - hGST + GSH derivative<br />
+
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**[[1gse]] – hGST (mutant) + GSH + ethacrynic acid<br />
+
-
**[[3ik9]] - hGST A1-1 + GSDN<br />
+
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**[[4hj2]] - hGST A1-1 + chemotherapeutic drug<br />
+
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**[[5jcu]] - hGST A1-1 + inhibitor<br />
+
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**[[2vct]] - hGST A2-2 + steroid<br />
+
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**[[2vcv]] - hGST A3-3 + steroid<br />
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**[[1gul]] - hGST A4-4+ iodobenzyl-GSH<BR />
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**[[3ik7]] - hGST A4-4 + GSDHN <br />
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**[[1b48]] - mGST A4-4 + GSH derivative<br />
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**[[1f3b]] - mGST A1-1 + GSH derivative<br />
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**[[1ml6]] - mGST A2-2+ GSH derivative<br />
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**[[1ev4]], [[1ev9]] - rGST A1-1 (mutant) + GSH derivative<br />
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**[[1vf2]], [[1vf3]] – GgGST A1-1 + GSH derivative<br />
+
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*GST δ class
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**[[1r5a]], [[1v2a]], [[1pn9]] - AcGST + GSH derivative <br />
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-
**[[3f63]], [[3g7i]] - AdGST + GSH derivative - ''Anopheles dirus''<br />
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**[[3f6d]], [[3g7j]] - AdGST )mutant) + GSH derivative<br />
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**[[3ein]] - DmGST + GSH<BR />
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**[[3vk9]] - siGST <br />
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**[[4i97]] – GST + GSH – ''Scaptomyza nigrita''<br />
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**[[3wyw]] – GST + GSH – brown planthopper<br />
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**[[5f0g]] – DmGST-2 <br />
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*GST ε class
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**[[2il3]] - AgGST – ''Anopheles gambiae''<br />
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-
**[[2imi]] - AgGST + GSH<BR />
+
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**[[2imk]], [[4gsn]] - AgGST + GSH derivative<br />
+
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**[[3zmk]], [[3zml]] - GST + GSH – ''Anopheles funestus''<br />
+
-
**[[5ft3]] - GST + GSH – ''Aedes aegypti''<br />
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**[[4yh2]] - DmGST + GSH <br />
+
-
**[[5ld0]], [[5lcz]] – hGST/rGST<br />
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+
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*GST κ class
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**[[3rpp]] - hGST <br />
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**[[1r4w]] - rGST + GSH derivative<br />
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**[[1yzx]], [[3rpn]] - hGST + GSH derivative<br />
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*GST μ class
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**[[1gsb]], [[1gsc]] – rGST<br />
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**[[6gsu]], [[6gsv]], [[6gsw]], [[6gsx]], [[6gsy]], [[5fwg]], [[3fyg]] - rGST (mutant) <br />
+
-
**[[1gtu]], [[2gtu]], [[3gtu]], [[4gtu]] - hGST<br />
+
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**[[2dc5]] - mGST <br />
+
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**[[2wrt]] - FhGST
+
-
 
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*''GST μ class complex with GSH''
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**[[1xw5]], [[1xw6]] - hGST + GSH<BR />
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**[[2f8f]] - mGST (mutant) + GSH<BR />
+
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**[[3crt]], [[4wr4]], [[4wr5]] - SjGST + GSH<BR />
+
-
**[[3cru]], [[3d0z]] - SjGST (mutant) + GSH<BR />
+
-
**[[6gst]] - rGST + GSH<br />
+
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**[[4q5q]] – GST + GSH – dust mite<br />
+
-
 
+
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*''GST μ class complex''
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**[[1c72]] - GgGST + conjugate<br />
+
-
**[[1hna]], [[1hnb]], [[1hnc]], [[1xwk]], [[1ykc]], [[1yj6]], [[2ab6]], [[2f3m]] – hGST + GSH derivative<br />
+
-
**[[1xwk]], [[1yj6]], [[2f3m]] – hGST-1 + GSH derivative<br />
+
-
**[[1ykc]], [[2ab6]] – hGST-2 + GSH derivative<br />
+
-
**[[2c4j]] - hGST-2 (mutant) + GSH derivative<br />
+
-
**[[1b4p]] - rGST + GSH derivative<br />
+
-
**[[3gur]] - hGST-2 + GSH + drug<br />
+
-
**[[5hwl]] – hGST-2 + GSH + acetamide derivative<br />
+
-
**[[1gsu]] - cGST + GSH derivative<br />
+
-
**[[4ai6]], [[4akg]] – SjGST + ATP + ADP<br />
+
-
**[[4aki]] – SjGST + ATP<br />
+
-
**[[4akh]] – SjGST + AMPPNP <br />
+
-
**[[5gzz]] – SjGST + JAR1 + GSH <br />
+
-
 
+
-
*GST ν class
+
-
 
+
-
**[[2ws2]] - GST – ''Haemonchus contortus''<br />
+
-
**[[4mzw]] – GST + GSH derivative – ''Streptococcus sanguinis''<br />
+
-
 
+
-
*GST π class
+
-
 
+
-
**[[1bay]] - mGST <br />
+
-
**[[10gs]], [[14gs]], [[16gs]], [[1lbk]], [[5dak]], [[5dal]], [[5dcg]], [[5djm]] - hGST<br />
+
-
**[[22gs]], [[1eog]], [[1eoh]], [[3hjm]], [[3hkr]], [[3kmn]] - hGST (mutant)<br />
+
-
**[[5djl]] – hGST + GSH <br />
+
-
**[[5ddl]] – hGST + GSH + GSH derivative <br />
+
-
**[[4ecb]], [[4ecc]] – SjGST/hKininogen peptide<br />
+
-
 
+
-
*''GST π class complex with GSH''
+
-
 
+
-
**[[1gsy]] - mGST + GSH<BR />
+
-
**[[1tu7]], [[2hnl]] - OvGST + GSH - ''Onchocerca volvulus''<br />
+
-
**[[5gss]], [[6gss]], [[7gss]], [[8gss]], [[19gs]], [[3dd3]] - hGST + GSH<BR />
+
-
**[[5jcw]] - hGST + GSH + phenethyl isocyanate<br />
+
-
**[[1md3]], [[1md4]], [[1px6]], [[1px7]], [[1kbn]] - hGST (mutant) + GSH<br />
+
-
**[[5l6x]] - hGST (mutant) + GSH derivative<br />
+
-
**[[5d73]] - GST + GSH – ''Wuchereria bancrofti''
+
-
 
+
-
*''GST π class complex''
+
-
+
-
**[[1gss]] – rGST + GSH derivative<br />
+
-
**[[1tu8]] - OvGST + GSH derivative<br />
+
-
**[[1glq]], [[1glp]], [[2glr]], [[1gti]] - mGST + GSH derivative<br />
+
-
**[[2oac]], [[2oad]], [[2oa7]], [[3o76]] - mGST (mutant) + GSH derivative<br />
+
-
**[[2gss]], [[3dgq]] – hGST + ethacrynic acid<br />
+
-
**[[3n9j]] - hGST + ethacrynic acid derivative<br />
+
-
**[[3gss]], [[11gs]] – hGST + ethacrynic acid + GSH<BR />
+
-
**[[3hjo]], [[3km6]], [[3kmo]] - hGST (mutant) + ethacrynic acid + GSH<BR />
+
-
**[[1pgt]], [[2pgt]], [[4gss]], [[17gs]], [[2j9h]], [[3csi]] - hGST (mutant) + GSH derivative<br />
+
-
**[[1aqw]], [[1aqx]], [[9gss]], [[12gs]], [[18gs]], [[3pgt]], [[4pgt]], [[1zgn]], [[2a2r]], [[2a2s]], [[3csh]] - hGST + GSH derivative<br />
+
-
**[[20gs]] - hGST + cibacron blue<br />
+
-
**[[13gs]], [[3csj]], [[1gus]] - hGST + drug<br />
+
-
**[[3ie3]] - hGST (mutant) + drug<br />
+
-
**[[5x79]] – hGST + inhibitor <br />
+
-
**[[5j41]] – hGST + piperlongumine + GSH <br />
+
-
**[[2gsr]] - GST + GSH derivative - pig
+
-
 
+
-
*GST ρ class
+
-
 
+
-
**[[3qav]] - AcGST – Atlantic clam<br />
+
-
**[[3qaw]] - AcGST + GSH<BR />
+
-
 
+
-
*GST σ class
+
-
 
+
-
**[[2c8u]], [[2cai]] - ShGST (mutant) <br />
+
-
**[[3vpt]], [[4e8h]] – siGST <br />
+
-
**[[2ca8]] - ShGST + GSH<BR />
+
-
**[[2wb9]] - FhGST + GSH<br />
+
-
**[[2wdu]] - FhGST + GSH + GSH derivative<br />
+
-
**[[1zl9]] - CeGST + GSH<BR />
+
-
**[[1iyh]], [[1iyi]] - hGST + GSH<BR />
+
-
**[[3vi7]] - hGST (mutant) + GSH<BR />
+
-
**[[1v40]], [[2cvd]], [[3ee2]], [[3kxo]], [[4ec0]], [[4edz]], [[4ee0]], [[4edy]], [[2vcq]], [[2vcw]], [[2vcx]], [[2vcz]], [[2vd0]], [[2vd1]] - hGST + GSH + inhibitor<br />
+
-
**[[3vi5]], [[3vi7]] - hGST (mutant) + GSH + inhibitor<br />
+
-
**[[4imn]] – hGST + PEG<br />
+
-
**[[4imo]] – hGST + substrate analog<br />
+
-
**[[2caq]] - ShGST (mutant) + GSH<BR />
+
-
**[[1pd2]] - rGST + GSH<BR />
+
-
**[[2c80]] - ShGST + GSH derivative<br />
+
-
**[[1gsq]] - sqGST + GSH derivative<br />
+
-
**[[3vpq]] – siGST + GSH<br />
+
-
**[[3vur]] – siGST + GSH derivative<br />
+
-
**[[4q5f]] – GST + GSH – pig roundworm<br />
+
-
**[[4q5r]] – GST + GSH – cockroach<br />
+
-
 
+
-
*GST ϑ class
+
-
 
+
-
**[[2ljr]], [[2c3n]], [[4mpf]] - hGST <br />
+
-
**[[2c3t]] - hGST (mutant) <br />
+
-
**[[1ljr]], [[4mpg]] - hGST + GSH<BR />
+
-
**[[3mak]] - DmGST + GSH<BR />
+
-
**[[3ljr]] - hGST + GSH derivative<br />
+
-
**[[2c3q]] - hGST (mutant) + GSH derivative<br />
+
-
 
+
-
*GST χ class
+
-
 
+
-
**[[3ppu]] - PcGST + GSH
+
-
 
+
-
*GST ω class
+
-
 
+
-
**[[1eem]] – hGST<br />
+
-
**[[3vln]], [[4is0]] – hGST-1 (mutant)<br />
+
-
**[[3lfl]] – hGST-1 + GSH <br />
+
-
**[[4yqm]], [[4yqu]], [[4yqv]], [[5v3q]], [[5ueh]] – hGST-1 + inhibitor<br />
+
-
**[[3qag]], [[3q19]] – hGST-2 (mutant) + GSH <br />
+
-
**[[3q18]] – hGST-2 (mutant)<br />
+
-
**[[3wd6]] – GST + GSH – silk moth<br />
+
-
**[[3rbt]] - siGST <br />
+
-
 
+
-
*GST ζ class
+
-
 
+
-
**[[1e6b]] – AtGST<br />
+
-
**[[2cz3]] - mGST <br />
+
-
**[[2cz2]] - mGST + GSH<BR />
+
-
**[[1fw1]] - hGST + GSH
+
-
 
+
-
*GST τ class
+
-
 
+
-
**[[1gwc]] - GST – wheat<br />
+
-
**[[5g5e]] - MiGST – ''Mangifera indica''<br />
+
-
**[[5g5f]] - MiGST + GSH<br />
+
-
**[[5kej]] - MiGST + GSH derivative<br />
+
-
**[[2vo4]], [[4chs]] - sGST + GSH derivative – soybean<br />
+
-
**[[5agy]] - sGST (mutant) + GSH derivative<br />
+
-
**[[4top]] - sGST + GSH<BR />
+
-
**[[6ep6]], [[5o84]] – AtGST <br />
+
-
**[[5ecs]], [[6ep7]] – AtGST + GSH <br />
+
-
**[[5g5a]] - AtGST + GSH derivative<br />
+
-
**[[5ech]], [[5eci]], [[5eck]], [[5ecl]], [[5ecm]], [[5ecn]], [[5eco]] [[5ecp]], [[5ecq]], [[5ecr]] – AtGST + JAR1 + GSH + ATP <br />
+
-
 
+
-
*Microsomal GST
+
-
**[[2h8a]], [[5i9k]] - rGST + GSH<BR />
 
-
**[[5ia9]] - rGST + GSH derivative<br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Glutathione S-tansferase complex with glutathione (PDB entry 1fhe)

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References

  1. ↑ Oakley A. Glutathione transferases: a structural perspective. Drug Metab Rev. 2011 May;43(2):138-51. doi: 10.3109/03602532.2011.558093. Epub, 2011 Mar 23. PMID:21428697 doi:http://dx.doi.org/10.3109/03602532.2011.558093
  2. ↑ Wongsantichon J, Robinson RC, Ketterman AJ. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Biosci Rep. 2015 Oct 20;35(6). pii: e00272. doi: 10.1042/BSR20150183. PMID:26487708 doi:http://dx.doi.org/10.1042/BSR20150183
  3. ↑ Morel F, Aninat C. The glutathione transferase kappa family. Drug Metab Rev. 2011 May;43(2):281-91. PMID:21428694 doi:10.3109/03602532.2011.556122
  4. ↑ Nazar-Stewart V, Motulsky AG, Eaton DL, White E, Hornung SK, Leng ZT, Stapleton P, Weiss NS. The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma. Cancer Res. 1993 May 15;53(10 Suppl):2313-8 PMID:8485718
  5. ↑ Kontur WS, Bingman CA, Olmsted CN, Wassarman DR, Ulbrich A, Gall DL, Smith RW, Yusko LM, Fox BG, Noguera DR, Coon JJ, Donohue TJ. Novosphingobium aromaticivorans uses a Nu-class glutathione-S-transferase as a glutathione lyase in breaking the beta-aryl ether bond of lignin. J Biol Chem. 2018 Feb 15. pii: RA117.001268. doi: 10.1074/jbc.RA117.001268. PMID:29449375 doi:http://dx.doi.org/10.1074/jbc.RA117.001268
  6. ↑ Henderson CJ, McLaren AW, Moffat GJ, Bacon EJ, Wolf CR. Pi-class glutathione S-transferase: regulation and function. Chem Biol Interact. 1998 Apr 24;111-112:69-82. PMID:9679544 doi:10.1016/s0009-2797(97)00176-2
  7. ↑ Pandey T, Chhetri G, Chinta R, Kumar B, Singh DB, Tripathi T, Singh AK. Functional classification and biochemical characterization of a novel rho class glutathione S-transferase in Synechocystis PCC 6803. FEBS Open Bio. 2014 Nov 24;5:1-7. PMID:25685659 doi:10.1016/j.fob.2014.11.006
  8. ↑ Sánchez Pérez LC, Zubillaga RA, García-Gutiérrez P, Landa A. Sigma-Class Glutathione Transferases (GSTσ): A New Target with Potential for Helminth Control. Trop Med Infect Dis. 2024 Apr 16;9(4):85. PMID:38668546 doi:10.3390/tropicalmed9040085
  9. ↑ Board PG. The omega-class glutathione transferases: structure, function, and genetics. Drug Metab Rev. 2011 May;43(2):226-35. PMID:21495794 doi:10.3109/03602532.2011.561353
  10. ↑ Board PG, Anders MW. Glutathione transferase zeta: discovery, polymorphic variants, catalysis, Drug Metab Rev. 2011 May;43(2):215-25. PMID:21303221 doi:10.3109/03602532.2010.549132
  11. ↑ Kilili KG, Atanassova N, Vardanyan A, Clatot N, Al-Sabarna K, Kanellopoulos PN, Makris AM, Kampranis SC. Differential roles of tau class glutathione S-transferases in oxidative stress. J Biol Chem. 2004 Jun 4;279(23):24540-51. PMID:15037622 doi:10.1074/jbc.M309882200
  12. ↑ Munyampundu JP, Xu YP, Cai XZ. Phi Class of Glutathione S-transferase Gene Superfamily Widely Exists in Nonplant Taxonomic Groups. Evol Bioinform Online. 2016 Feb 10;12:59-71. PMID:26884677 doi:10.4137/EBO.S35909
  13. ↑ Morgenstern R, Zhang J, Johansson K. Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab Rev. 2011 May;43(2):300-6. PMID:21495795 doi:10.3109/03602532.2011.558511
  14. ↑ Rossjohn J, Feil SC, Wilce MC, Sexton JL, Spithill TW, Parker MW. Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase. J Mol Biol. 1997 Nov 7;273(4):857-72. PMID:9367777 doi:10.1006/jmbi.1997.1338

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