6r2x
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of Chromogranin A (F39-D63)== | |
| + | <StructureSection load='6r2x' size='340' side='right'caption='[[6r2x]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6r2x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R2X FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2x OCA], [https://pdbe.org/6r2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r2x RCSB], [https://www.ebi.ac.uk/pdbsum/6r2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CMGA_HUMAN CMGA_HUMAN] Pancreastatin strongly inhibits glucose induced insulin release from the pancreas. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound (5) that has high affinity and bi-selectivity for alphavbeta6 and alphavbeta8 integrins and is stable in microsomal preparations. 5 is suitable for nanoparticle functionalization and delivery to cancer cells, holding promise for diagnostic and/or therapeutic applications. | ||
| - | + | A stapled chromogranin A-derived peptide is a potent dual ligand for integrins alphavbeta6 and alphavbeta8.,Nardelli F, Ghitti M, Quilici G, Gori A, Luo Q, Berardi A, Sacchi A, Monieri M, Bergamaschi G, Bermel W, Chen F, Corti A, Curnis F, Musco G Chem Commun (Camb). 2019 Nov 22. doi: 10.1039/c9cc08518a. PMID:31755501<ref>PMID:31755501</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6r2x" style="background-color:#fffaf0;"></div> |
| - | [[Category: Berardi | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Ghitti | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Berardi A]] |
| + | [[Category: Corti A]] | ||
| + | [[Category: Curnis F]] | ||
| + | [[Category: Ghitti M]] | ||
| + | [[Category: Gori A]] | ||
| + | [[Category: Musco G]] | ||
| + | [[Category: Nardelli F]] | ||
| + | [[Category: Quilici G]] | ||
Current revision
NMR structure of Chromogranin A (F39-D63)
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Categories: Homo sapiens | Large Structures | Berardi A | Corti A | Curnis F | Ghitti M | Gori A | Musco G | Nardelli F | Quilici G
