6r7g
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6r7g is ON HOLD Authors: Grinzato, A., Kandiah, E., Lico, C., Betti, C., Baschieri, S., Zanotti, G. Description: Atomic structure of potato virus X...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Atomic structure of potato virus X, the prototype of the Alphaflexiviridae family== | |
| + | <StructureSection load='6r7g' size='340' side='right'caption='[[6r7g]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6r7g]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Potato_virus_X Potato virus X]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R7G FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7g OCA], [https://pdbe.org/6r7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r7g RCSB], [https://www.ebi.ac.uk/pdbsum/6r7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAPSD_PVXX3 CAPSD_PVXX3] Required for genome encapsidation. Forms ribonucleoprotein complexes along with TGB1 helicase and viral RNA. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Potato virus X (PVX) is a positive-sense single-stranded RNA (ssRNA) filamentous plant virus belonging to the Alphaflexiviridae family, considered in recent years as a tool for nanotechnology applications. We present the cryo-electron microscopy structure of the PVX particle at a resolution of 2.2 A. The well-defined density of the coat proteins and of the genomic RNA allowed a detailed analysis of protein-RNA interactions, including those mediated by solvent molecules. The particle is formed by repeated segments made of 8.8 coat proteins, forming a left-handed helical structure. The RNA runs in an internal crevice along the virion, packaged in 5-nucleotide repeats in which the first four bases are stacked in the classical way, while the fifth is rotated and nearly perpendicular. The resolution of the structure described here suggests a mechanism for the virion assembly and potentially provides a platform for the rational design of antiviral compounds and for the use of PVX in nanotechnology. | ||
| - | + | Atomic structure of potato virus X, the prototype of the Alphaflexiviridae family.,Grinzato A, Kandiah E, Lico C, Betti C, Baschieri S, Zanotti G Nat Chem Biol. 2020 Mar 16. pii: 10.1038/s41589-020-0502-4. doi:, 10.1038/s41589-020-0502-4. PMID:32203412<ref>PMID:32203412</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6r7g" style="background-color:#fffaf0;"></div> |
| - | [[Category: Betti | + | |
| - | [[Category: Grinzato | + | ==See Also== |
| - | [[Category: | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Potato virus X]] | ||
| + | [[Category: Baschieri S]] | ||
| + | [[Category: Betti C]] | ||
| + | [[Category: Grinzato A]] | ||
| + | [[Category: Kandiah E]] | ||
| + | [[Category: Lico C]] | ||
| + | [[Category: Zanotti G]] | ||
Current revision
Atomic structure of potato virus X, the prototype of the Alphaflexiviridae family
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Categories: Large Structures | Potato virus X | Baschieri S | Betti C | Grinzato A | Kandiah E | Lico C | Zanotti G
