Aminoacyl tRNA synthetase 3D structures

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Current revision (10:14, 24 September 2024) (edit) (undo)
 
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Line 12: Line 12:
**[[4q2y]] – hArgRS (mutant) <br />
**[[4q2y]] – hArgRS (mutant) <br />
**[[1bs2]] – yArgRS - yeast<br />
**[[1bs2]] – yArgRS - yeast<br />
-
**[[3gdz]] – ArgRS residues 1-106 – ''Klebsiella pneumoniae''<br />
+
**[[3gdz]] – KpArgRS residues 1-106 – ''Klebsiella pneumoniae''<br />
**[[1iq0]] – TtArgRS - ''Thermus thermophilus''<br />
**[[1iq0]] – TtArgRS - ''Thermus thermophilus''<br />
Line 23: Line 23:
* ''Arg-RS + tRNA''
* ''Arg-RS + tRNA''
-
**[[2zuf]] - PhArgRS + tRNA-Arg - ''Pyrococcus horikoshii''<br />
+
 
**[[1f7v]] - yArgRS + Arg-tRNA<br />
**[[1f7v]] - yArgRS + Arg-tRNA<br />
 +
**[[2zuf]] - PhArgRS + tRNA-Arg - ''Pyrococcus horikoshii''<br />
**[[5yyn]], [[5b63]] - EcArgRS + Arg-tRNA<br />
**[[5yyn]], [[5b63]] - EcArgRS + Arg-tRNA<br />
Line 41: Line 42:
**[[3sp1]] - BbCysRS – ''Borrelia burgdorferi''<br />
**[[3sp1]] - BbCysRS – ''Borrelia burgdorferi''<br />
**[[3c8z]] – MsCysRS + Cys-SA - ''Mycobacterium smegmatis''<br />
**[[3c8z]] – MsCysRS + Cys-SA - ''Mycobacterium smegmatis''<br />
 +
**[[6ujd]] - ElCysRS (mutant) – ''Elizabethkingia'' <br />
*'''Gln-RS'''
*'''Gln-RS'''
Line 49: Line 51:
**[[3tl4]] – yGlnRS tRNA-binding domain<br />
**[[3tl4]] – yGlnRS tRNA-binding domain<br />
**[[1nyl]] – EcGlnRS<br />
**[[1nyl]] – EcGlnRS<br />
 +
**[[5zdo]] – TtGlnRS<br />
 +
**[[5zdk]], [[5zdl]] – TtGlnRS + ATP<br />
**[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br />
**[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br />
**[[5bnz]] – PaGlnRS – ''Pseudomonas aeruginosa'' <br />
**[[5bnz]] – PaGlnRS – ''Pseudomonas aeruginosa'' <br />
Line 57: Line 61:
* ''Gln-RS ternary complex''
* ''Gln-RS ternary complex''
 +
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br />
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br />
Line 76: Line 81:
**[[5tgt]] – PaGluRS <br />
**[[5tgt]] – PaGluRS <br />
**[[5h4v]] – GluRS – ''Xanthomonas oryzae'' <br />
**[[5h4v]] – GluRS – ''Xanthomonas oryzae'' <br />
 +
**[[7k86]] – SmGluRS – ''Stenotrophomonas maltophilia'' <br />
* ''Glu-RS + small substrates or analogs''
* ''Glu-RS + small substrates or analogs''
 +
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br />
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br />
Line 89: Line 96:
* ''Glu-RS + tRNA''
* ''Glu-RS + tRNA''
 +
**[[1zjw]] – EcGluRS + Glu-tRNA<br />
**[[1zjw]] – EcGluRS + Glu-tRNA<br />
**[[1g59]] – TtGluRS + Glu-tRNA<br />
**[[1g59]] – TtGluRS + Glu-tRNA<br />
* ''Glu-RS ternary complex''
* ''Glu-RS ternary complex''
 +
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br />
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br />
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br />
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br />
Line 105: Line 114:
**[[1ile]] - TtIleRS<br />
**[[1ile]] - TtIleRS<br />
-
**[[1wny]], [[1udz]] – TtIleRS editing domain<br />
+
**[[1wny]], [[1udz]] – TtIleRS editing domain 201-381<br />
* ''Ile-RS + small substrates or analogs''
* ''Ile-RS + small substrates or analogs''
 +
**[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
Line 115: Line 125:
* ''Ile-RS ternary complex''
* ''Ile-RS ternary complex''
 +
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br />
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br />
 +
**[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br />
-
*'''Leu-RS'''
+
*'''Leu-RS'''; Domains – editing 260-530;
-
**[[2wfd]] – hLeuRS editing domain<br />
+
**[[2wfd]] – hLeuRS editing domain 260-509<br />
-
**[[3o0a]], [[3pz0]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />
+
**[[3o0a]], [[3pz0]] – AaLeuRS editing domain – ''Aquifex aeolicus''<br />
-
**[[3pz5]] – AaLeuRS hydrolytic domain (mutant)<br />
+
**[[3pz5]] – AaLeuRS editing domain (mutant)<br />
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
**[[5agh]] - CaLeuRS editing domain (mutant)<br />
**[[5agh]] - CaLeuRS editing domain (mutant)<br />
-
**[[2ajg]] - EcLeuRS editing domain<br />
+
**[[2ajg]] - EcLeuRS editing domain 228-413<br />
**[[1wkb]] – PhLeuRS residues 1-810<br />
**[[1wkb]] – PhLeuRS residues 1-810<br />
**[[5fon]] - CmLeuRS editing domain – ''Cryptosporidium muris''<br />
**[[5fon]] - CmLeuRS editing domain – ''Cryptosporidium muris''<br />
Line 132: Line 144:
**[[4k48]] - SpLeuRS editing domain (mutant) – ''Streptococcus pneumoniae''<br />
**[[4k48]] - SpLeuRS editing domain (mutant) – ''Streptococcus pneumoniae''<br />
**[[3pz6]] - LeuRS editing domain (mutant) – ''Giardia intestinalis''<br />
**[[3pz6]] - LeuRS editing domain (mutant) – ''Giardia intestinalis''<br />
 +
**[[7nu4]] - NgLeuRS<br />
 +
**[[7nty]], [[7nu1]], [[7nua]] - NgLeuRS (mutant)<br />
 +
**[[7n11]] - MaLeuRS editing domain – ''Mycobacteroides abscessus''<br />
* ''Leu-RS + small substrates or analogs''
* ''Leu-RS + small substrates or analogs''
 +
 +
**[[6kqy]] - hLeuRS + Leu<br />
 +
**[[7d5c]] - yLeuRS + inhibitor<br />
 +
**[[7nu5]] - NgLeuRS + Leu<br />
 +
**[[6ykk]], [[6ykl]], [[6ykn]], [[6yko]], [[6ykq]], [[6yks]], [[6ykt]], [[6yku]], [[6ykv]], [[6kyw]], [[6ykx]], [[7a0p]], [[7ap2]] - NgLeuRS (mutant) + inhibitor<br />
 +
**[[6q89]], [[6q8a]], [[6q8b]], [[6q8c]], [[7ntz]], [[7nu2]], [[7nub]] - NgLeuRS (mutant) + intermediate analog<br />
 +
**[[7nu6]], [[7nu7]] - NgLeuRS + ATP <br />
 +
**[[7nu9]] - NgLeuRS + ATP + leucinol<br />
 +
**[[7nu3]], [[7nuc]] - NgLeuRS (mutant) + ATP + leucinol<br />
 +
**[[7nu8]] - NgLeuRS + Leu-AMP <br />
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
**[[1h3n]] - TtLeuRS + Leu-SA<br />
**[[1h3n]] - TtLeuRS + Leu-SA<br />
Line 146: Line 171:
**[[5agi]] - CaLeuRS editing domain (mutant) + AMP derivative<br />
**[[5agi]] - CaLeuRS editing domain (mutant) + AMP derivative<br />
**[[5agr]], [[5ags]], [[5agt]] - MtLeuRS editing domain + inhibitor<br />
**[[5agr]], [[5ags]], [[5agt]] - MtLeuRS editing domain + inhibitor<br />
 +
**[[7bzj]] - SpLeuRS + inhibitor<br />
**[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br />
**[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br />
**[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br />
**[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br />
 +
**[[7n12]] - MaLeuRS editing domain + epetraborole-AMP<br />
* ''Leu-RS + tRNA''
* ''Leu-RS + tRNA''
 +
**[[1wz2]] – PhLeuRS + Leu-tRNA<br />
**[[1wz2]] – PhLeuRS + Leu-tRNA<br />
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br >
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br >
* ''Leu-RS ternary complex''
* ''Leu-RS ternary complex''
 +
 +
**[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br />
 +
**[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br />
 +
**[[6kid]] - hLeuRS + ATP + Leu<br />
**[[4arc]] - EcLeuRS + Leu-tRNA + Leu<br />
**[[4arc]] - EcLeuRS + Leu-tRNA + Leu<br />
**[[5omw]] - EcLeuRS + Leu-tRNA + Leu-adenylate analog <br />
**[[5omw]] - EcLeuRS + Leu-tRNA + Leu-adenylate analog <br />
Line 168: Line 200:
**[[3bju]] – hLysRS residues 70-579<br />
**[[3bju]] – hLysRS residues 70-579<br />
-
**[[6ilh]] - hLysRS (mutant)<br />
+
**[[6ilh]], [[7ea9]] - hLysRS (mutant)<br />
 +
**[[7f6w]] – yLysRS<br />
**[[1irx]] – PhLysRS<br />
**[[1irx]] – PhLysRS<br />
**[[1bbw]] – EcLysRS<br />
**[[1bbw]] – EcLysRS<br />
Line 185: Line 218:
**[[3e9h]], 3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br />
**[[3e9h]], 3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br />
**[[3a74]] - BsLysRS + diadenosine tetraphosphate<br />
**[[3a74]] - BsLysRS + diadenosine tetraphosphate<br />
-
**[[5zh2]], [[5zh3]], [[5zh4]], [[5zh5]], [[4pg3]] - PfLysRS + inhibitor <br />
+
**[[5zh2]], [[5zh3]], [[5zh4]], [[5zh5]], [[4pg3]], [[6hcv]] - PfLysRS + inhibitor <br />
**[[4ycv]] - PfLysRS + cladosporin<br />
**[[4ycv]] - PfLysRS + cladosporin<br />
**[[5vl1]] - MuLysRS + Lys – ''Mycobacterium ulcerans''<br />
**[[5vl1]] - MuLysRS + Lys – ''Mycobacterium ulcerans''<br />
Line 194: Line 227:
**[[5eln]] - CpLysRS + Lys <br />
**[[5eln]] - CpLysRS + Lys <br />
**[[4ex5]] - BtLysRS + Lys <br />
**[[4ex5]] - BtLysRS + Lys <br />
 +
**[[6wbd]] - SmLysRS + Lys <br />
*''Lys-RS ternary complexes''
*''Lys-RS ternary complexes''
Line 203: Line 237:
**[[1e24]] - EcLysRS + Lys + ATP<br />
**[[1e24]] - EcLysRS + Lys + ATP<br />
**[[6nrz]] - CtLysRS + Lys + adenosine – ''Chlamydia trachomatis''<br />
**[[6nrz]] - CtLysRS + Lys + adenosine – ''Chlamydia trachomatis''<br />
-
**[[6ns0]] - CtLysRS + Lys + cladosporin<br />
+
**[[6ns0]], [[6o3f]] - CtLysRS + Lys + cladosporin<br />
**[[6bni]] - CpLysRS + Lys + adenine<br />
**[[6bni]] - CpLysRS + Lys + adenine<br />
**[[5elo]] - CpLysRS + Lys + cladosporin <br />
**[[5elo]] - CpLysRS + Lys + cladosporin <br />
**[[6aqg]] - MuLysRS + Lys + cladosporin <br />
**[[6aqg]] - MuLysRS + Lys + cladosporin <br />
 +
**[[6agt]], [[6ka6]], [[6kab]], [[6kbf]], [[6kcn]], [[6kct]] - PfLysRS + Lys + cladosporin derivative<br />
 +
**[[7bt5]] - PfLysRS + Lys + drug<br />
 +
**[[6hcu]], [[6hcw]] - PfLysRS + Lys + inhibitor<br />
**[[6aqh]] - LysRS + Lys + cladosporin – ''Mycobacterium thermoresistibile''<br />
**[[6aqh]] - LysRS + Lys + cladosporin – ''Mycobacterium thermoresistibile''<br />
Line 215: Line 252:
**[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br />
**[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br />
**[[1qqt]], [[3h9c]] - EcMetRS residues 2-552<br />
**[[1qqt]], [[3h9c]] - EcMetRS residues 2-552<br />
-
**[[3h97]] – EcMetRS residues 2-548 (mutant) <br />
+
**[[3h97]], [[6spp]] – EcMetRS residues 2-548 (mutant) <br />
**[[1a8h]] – TtMetRS<br />
**[[1a8h]] – TtMetRS<br />
**[[2d54]], [[2d5b]] – TtMetRS (mutant) <br />
**[[2d54]], [[2d5b]] – TtMetRS (mutant) <br />
Line 223: Line 260:
**[[1mkh]] – PabMetRS C-terminal<br />
**[[1mkh]] – PabMetRS C-terminal<br />
**[[5xgq]] – MtMetRS<br />
**[[5xgq]] – MtMetRS<br />
-
**[[5h34]] – MetRS C-terminal – ''Nanoarchaeum equitans''<br />
+
**[[5h34]] – NeMetRS C-terminal – ''Nanoarchaeum equitans''<br />
**[[2x1l]] - MsMetRS residues 2-515 <br />
**[[2x1l]] - MsMetRS residues 2-515 <br />
 +
**[[7wpj]] – SaMetRS<br />
* ''Met-RS + small substrates or analogs''
* ''Met-RS + small substrates or analogs''
 +
**[[5goy]] – hMetRS residues 221-834 + Met<br />
**[[5goy]] – hMetRS residues 221-834 + Met<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
Line 232: Line 271:
**[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br />
**[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br />
**[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br />
**[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br />
-
**[[1f4l]] - EcMetRS residues 1-551 + Met<br />
+
**[[1f4l]], [[6spo]] - EcMetRS residues 1-551 + Met<br />
 +
**[[6spq]] - EcMetRS (mutant) + Met<br />
 +
**[[6spn]] - EcMetRS + beta-Met<br />
 +
**[[6spr]] - EcMetRS (mutant) + beta-Met<br />
**[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br />
**[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br />
**[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br />
**[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br />
Line 244: Line 286:
**[[5k0s]], [[5k0t]] – MetRS + inhibitor – ''Brucella suis''<br />
**[[5k0s]], [[5k0t]] – MetRS + inhibitor – ''Brucella suis''<br />
**[[4zt2]], [[4zt3]], [[4zt4]], [[4zt5]], [[4zt6]], [[4zt7]], [[4mvw]], [[4mvx]], [[4mvy]], [[4mw0]], [[4mw1]], [[4mw2]], [[4mw4]], [[4mw5]], [[4mw6]], [[4mw7]], [[4mw9]], [[4mwb]], [[4mwc]], [[4mwd]], [[4mwe]] - TbMetRS residues 237-773 (mutant) + inhibitor – ''Trypanosoma brucei''<br />
**[[4zt2]], [[4zt3]], [[4zt4]], [[4zt5]], [[4zt6]], [[4zt7]], [[4mvw]], [[4mvx]], [[4mvy]], [[4mw0]], [[4mw1]], [[4mw2]], [[4mw4]], [[4mw5]], [[4mw6]], [[4mw7]], [[4mw9]], [[4mwb]], [[4mwc]], [[4mwd]], [[4mwe]] - TbMetRS residues 237-773 (mutant) + inhibitor – ''Trypanosoma brucei''<br />
 +
**[[6cml]], [[6mes]] - TbMetRS residues 237-773 (mutant) + Met + inhibitor <br />
**[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br />
**[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br />
 +
**[[7wpi]], [[7wpn]] - SaMetRS + inhibitor<br />
 +
**[[7wpk]] - SaMetRS + Met<br />
 +
**[[7wpl]] - SaMetRS + ATP<br />
 +
**[[7wpm]], [[7wpt]], [[7wpx]], [[7wq0]] - SaMetRS + inhibitor + ATP<br />
 +
**[[7ulz]] - PaMetRS + Met<br />
* ''Met-RS + tRNA''
* ''Met-RS + tRNA''
- 
**[[2csx]] – AaMetRS + Met-tRNA<br />
**[[2csx]] – AaMetRS + Met-tRNA<br />
Line 278: Line 325:
**[[5tev]] - NgTrpRS <br />
**[[5tev]] - NgTrpRS <br />
**[[4j76]] - PfTrpRS <br />
**[[4j76]] - PfTrpRS <br />
 +
**[[7el8]] - MtTrpRS <br />
* ''Trp-RS + small substrates or analogs''
* ''Trp-RS + small substrates or analogs''
 +
**[[5ujj]] – hTrpRS + Trp-AMP<br />
**[[5ujj]] – hTrpRS + Trp-AMP<br />
**[[2quh]] – hTrpRS + Trp<br />
**[[2quh]] – hTrpRS + Trp<br />
Line 291: Line 340:
**[[2ov4]] – BsTrpRS + adenosine tetraphosphate<br />
**[[2ov4]] – BsTrpRS + adenosine tetraphosphate<br />
**[[1i6k]], [[1i6l]], [[1i6m]] – BsTrpRS + Trp-adenylate<br />
**[[1i6k]], [[1i6l]], [[1i6m]] – BsTrpRS + Trp-adenylate<br />
 +
**[[1maw]], [[1m83]] - BsTrpRS + ATP<br />
 +
**[[1mb2]] - BsTrpRS + Trp<br />
 +
**[[7cms]] - BsTrpRS + antibiotic<br />
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br />
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br />
**[[1yi8]], [[1yia]]– DrTrpRS + Trp<br />
**[[1yi8]], [[1yia]]– DrTrpRS + Trp<br />
-
**[[1maw]], [[1m83]] - BsTrpRS + ATP<br />
 
-
**[[1mb2]] - BsTrpRS + Trp<br />
 
**[[1bks]] – StTrpRS + pyridoxal phosphate<br />
**[[1bks]] – StTrpRS + pyridoxal phosphate<br />
**[[6ncr]] - CtTrpRS + Trp<br />
**[[6ncr]] - CtTrpRS + Trp<br />
**[[5tew]] - NgTrpRS + Trp<br />
**[[5tew]] - NgTrpRS + Trp<br />
**[[4j75]] - PfTrpRS + Trp-AMP<br />
**[[4j75]] - PfTrpRS + Trp-AMP<br />
 +
**[[7elt]] - MtTrpRS + Trp-AMP<br />
 +
**[[6dfu]] - TrpRS + Trp – ''Haemophilus influenzae''<br />
*''Trp-RS ternary complex''
*''Trp-RS ternary complex''
-
**[[5ekd]] – hTrpRS + ATP + indolmycin<br />
+
**[[5ekd]] – hTrpRS + ATP + antibiotic<br />
-
**[[5dk4]] – BsTrpRS + ATP + indolmycin<br />
+
**[[5dk4]], [[7cki]] – BsTrpRS + ATP + antibiotic<br />
 +
**[[7eer]] – BsTrpRS + ATP + inhibitor<br />
**[[3fhj]], [[3ghd]], [[3fi0]] – BsTrpRS + Trp + AMP + Pi<br />
**[[3fhj]], [[3ghd]], [[3fi0]] – BsTrpRS + Trp + AMP + Pi<br />
**[[1mau]] – BsTrpRS + Trp + ATP<br />
**[[1mau]] – BsTrpRS + Trp + ATP<br />
**[[5v0i]] - EcTrpRS + Trp + AMP<br />
**[[5v0i]] - EcTrpRS + Trp + AMP<br />
 +
**[[7ens]] – MtTrpRS + ATP + antibiotic<br />
 +
**[[7ent]], [[7ev2]], [[7ev3]] – MtTrpRS + ATP + inhibitor<br />
* ''Trp-RS + tRNA''
* ''Trp-RS + tRNA''
 +
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br />
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br />
**[[2azx]] – hTrpRS (mutant) + tRNA<br />
**[[2azx]] – hTrpRS (mutant) + tRNA<br />
Line 320: Line 376:
**[[1tya]], [[1tyb]], [[1tyc]], [[1tyd]], [[2ts1]] – BsTyrRS<br />
**[[1tya]], [[1tyb]], [[1tyc]], [[1tyd]], [[2ts1]] – BsTyrRS<br />
**[[1jh3]] – BsTyrRS C-terminal – NMR<br />
**[[1jh3]] – BsTyrRS C-terminal – NMR<br />
-
**[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]], [[5n5v]], [[5nsf]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
+
**[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]], [[5n5v]], [[5nsf]], [[7c5c]], [[7ckh]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
**[[1u7x]], [[4hjr]], [[4hk4]], [[5u36]], [[5l7p]] - MjTyrRS (mutant) <br />
**[[1u7x]], [[4hjr]], [[4hk4]], [[5u36]], [[5l7p]] - MjTyrRS (mutant) <br />
**[[2jan]] – MtTyrRS<br />
**[[2jan]] – MtTyrRS<br />
Line 331: Line 387:
**[[2ktl]] - AnTyrRS C-terminal - NMR<br />
**[[2ktl]] - AnTyrRS C-terminal - NMR<br />
**[[5ijx]] - TyrRS – ''Coccidiodides posadasii''<br />
**[[5ijx]] - TyrRS – ''Coccidiodides posadasii''<br />
 +
**[[7fg6]] - NeTyrRS <br />
* ''Tyr-RS + small substrates or analogs''
* ''Tyr-RS + small substrates or analogs''
 +
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
Line 338: Line 396:
**[[4qbt]] - hTyrRS + Tyr<br />
**[[4qbt]] - hTyrRS + Tyr<br />
**[[3zxi]] - hTyrRS + Tyr-adenylate analog<br />
**[[3zxi]] - hTyrRS + Tyr-adenylate analog<br />
 +
**[[7rou]] – hTyrRS + Tyr derivative<br />
**[[3ts1]] – BsTyrRS + Tyr-adenylate intermediate<br />
**[[3ts1]] – BsTyrRS + Tyr-adenylate intermediate<br />
**[[4ts1]] – BsTyrRS + Tyr<br />
**[[4ts1]] – BsTyrRS + Tyr<br />
-
**[[3p0h]], 3p0i]], 3p0j]] – LmTyrRS + inhibitor <br />
+
**[[3p0h]], [[3p0i]], [[3p0j]] – LmTyrRS + inhibitor <br />
**[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
**[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
-
**[[1zh6]], [[2ag6]], [[4pbr]] - MjTyrRS (mutant) + Phe derivative<br />
+
**[[1zh6]], [[2ag6]], [[4pbr]], [[7ckg]] - MjTyrRS (mutant) + Phe derivative<br />
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
**[[4nx2]] - MjTyrRS (mutant) + di-chloro-Tyr<br />
**[[4nx2]] - MjTyrRS (mutant) + di-chloro-Tyr<br />
Line 354: Line 413:
**[[1x8x]] – EcTyrRS + Tyr<br />
**[[1x8x]] – EcTyrRS + Tyr<br />
**[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br />
**[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br />
 +
**[[6wn2]], [[6wrn]], [[6wrt]] - EcTyrRS (mutant) + Tyr derivative<br />
**[[4oud]] - EcTyrRS + bi-Phe <br />
**[[4oud]] - EcTyrRS + bi-Phe <br />
 +
**[[6i5y]] - EcTyrRS + Tyr-SA <br />
 +
**[[6hb5]] - EcTyrRS + Tyr-SC <br />
 +
**[[6hb6]], [[6hb7]] - EcTyrRS + Tyr-SU <br />
 +
**[[7ap3]] - EcTyrRS + inhibitor<br />
**[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus<br />
**[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus<br />
**[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br />
**[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br />
Line 360: Line 424:
**[[1h3f]]- TtTyrRS + Tyr-ol<br />
**[[1h3f]]- TtTyrRS + Tyr-ol<br />
**[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br />
**[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br />
 +
**[[6otj]] – NgTyrRS + Tyr<br />
 +
**[[7ror]] – PfTyrRS + Tyr-AMP<br />
 +
**[[7ros]] – PfTyrRS + Tyr derivative<br />
 +
**[[7rot]] – PfTyrRS (mutant) + Tyr derivative<br />
* ''Tyr-RS + tRNA''
* ''Tyr-RS + tRNA''
Line 367: Line 435:
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
**[[2rkj]] – NcTyrRS + RNA<br />
**[[2rkj]] – NcTyrRS + RNA<br />
 +
**[[7sc6]], [[7scq]] – TyrRS + RNA – ''Phaseolus vulgaris''<br />
*'''3-nitroTyr-RS'''
*'''3-nitroTyr-RS'''
Line 380: Line 449:
**[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
**[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
**[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA<br />
**[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA<br />
- 
*Class II aaRS
*Class II aaRS
Line 389: Line 457:
**[[4xeo]] - hAlaRS catalytic domain (mutant)<br />
**[[4xeo]] - hAlaRS catalytic domain (mutant)<br />
**[[5t5s]], [[5t76]] - hAlaRS residues 757-965<br />
**[[5t5s]], [[5t76]] - hAlaRS residues 757-965<br />
 +
**[[6nlq]], [[6nly]], [[6now]] - hAlaRS C-terminal<br />
**[[3g98]] – AaAlaRS residues 758-867<br />
**[[3g98]] – AaAlaRS residues 758-867<br />
**[[1riq]] - AaAlaRS catalytic fragment<br />
**[[1riq]] - AaAlaRS catalytic fragment<br />
Line 423: Line 492:
**[[5gro]] – HpAspRS N terminal<br />
**[[5gro]] – HpAspRS N terminal<br />
**[[4rmf]] – MsAspRS <br />
**[[4rmf]] – MsAspRS <br />
 +
**[[6wom]] – ElAspRS <br />
* ''Asp-RS + small substrates or analogs''
* ''Asp-RS + small substrates or analogs''
 +
**[[3nel]] – TkAspRS + Asp<br />
**[[3nel]] – TkAspRS + Asp<br />
**[[3nem]] - TkAspRS + Asp-adenylate<br />
**[[3nem]] - TkAspRS + Asp-adenylate<br />
Line 438: Line 509:
**[[5y6l]] - hAspRS + MetRS + Glu/ProRS + P18 + P38 <br />
**[[5y6l]] - hAspRS + MetRS + Glu/ProRS + P18 + P38 <br />
 +
**[[6iy6]] - hAspRS + AIMP2 + Glu/ProRS residues 1-157<br />
**[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate<br />
**[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate<br />
 +
**[[7ap4]] – TtAspRS + inhibitor<br />
 +
**[[6hhv]], [[6hhw]] – TtAspRS + Asp-SU<br />
 +
**[[6hhx]] – TtAspRS + Asp-SC<br />
 +
**[[6sjc]] – TtAspRS + Asp-SA<br />
**[[4wj4]] – PaAspRS + Asn-tRNA + Asp<br />
**[[4wj4]] – PaAspRS + Asn-tRNA + Asp<br />
**[[4wj3]] – PaAspRS + Asn-tRNA + amidotransferase<br />
**[[4wj3]] – PaAspRS + Asn-tRNA + amidotransferase<br />
Line 448: Line 524:
**[[1x56]] - PhAsnRS<br />
**[[1x56]] - PhAsnRS<br />
**[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''<br />
**[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''<br />
 +
**[[6pqh]] – ElAsnRS<br />
* ''Asn-RS + small substrates or analogs''
* ''Asn-RS + small substrates or analogs''
 +
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
Line 469: Line 547:
* ''Gly-RS + small substrates or analogs''
* ''Gly-RS + small substrates or analogs''
 +
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
Line 477: Line 556:
**[[5f5w]] - AaGlyRS + Gly-adenylate<br />
**[[5f5w]] - AaGlyRS + Gly-adenylate<br />
**[[3ufg]] - CjGlyRS + ATP<br />
**[[3ufg]] - CjGlyRS + ATP<br />
 +
**[[7eiv]] - EcGlyRS + ANP + Gly<br />
* ''Gly-RS + tRNA''
* ''Gly-RS + tRNA''
Line 485: Line 565:
*'''His-RS'''
*'''His-RS'''
-
**[[4x5o]], [[4g84]], [[4g85]] - hHisRS <br />
+
**[[4x5o]], [[4g84]], [[4g85]], [[6o76]] - hHisRS <br />
**[[5w6m]] - hHisRS (mutant)<br />
**[[5w6m]] - hHisRS (mutant)<br />
-
**[[1x59, [[2lw7]] – hHisRS WHEP-TRS domain - NMR<br />
+
**[[1x59]], [[2lw7]] – hHisRS WHEP-TRS domain - NMR<br />
**[[1htt]] - EcHisRS<br />
**[[1htt]] - EcHisRS<br />
**[[3net]] – HisRS – ''Nostoc''<br />
**[[3net]] – HisRS – ''Nostoc''<br />
Line 496: Line 576:
* ''His-RS + small substrates or analogs''
* ''His-RS + small substrates or analogs''
 +
**[[4phc]] - hHisRS + His <br />
**[[4phc]] - hHisRS + His <br />
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
Line 508: Line 589:
**[[3hrk]] - TbHisRS + His-adenylate<br />
**[[3hrk]] - TbHisRS + His-adenylate<br />
**[[2el9]] - EcHisRS + His-SA<br />
**[[2el9]] - EcHisRS + His-SA<br />
-
**[[1kmm]], 1ady]] - EcHisRS + His-adenylate<br />
+
**[[1kmm]], [[1ady]] - EcHisRS + His-adenylate<br />
**[[1kmn]] - EcHisRS + His-ol + ATP<br />
**[[1kmn]] - EcHisRS + His-ol + ATP<br />
**[[5e3i]] - AbHisRS + His + ATP<br />
**[[5e3i]] - AbHisRS + His + ATP<br />
Line 518: Line 599:
**[[5mgw]], [[5mgh]], [[5mgu]], [[5mgv]] – hPheRS (mutant)<br />
**[[5mgw]], [[5mgh]], [[5mgu]], [[5mgv]] – hPheRS (mutant)<br />
**[[1pys]] – TtPheRS<br />
**[[1pys]] – TtPheRS<br />
-
**[[2cxi]] – PhPheRS chain N-terminal<br />
+
**[[2cxi]] – PhPheRS β chain N-terminal<br />
-
**[[3ica]] – PheRS chain – ''Porphyromonas gingivalis''<br />
+
**[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis''<br />
-
**[[4p71]] – PaPheRS a+ chain<br />
+
**[[4p71]] – PaPheRS α+β chain<br />
-
**[[3ig2]] – PheRS chain – ''Bacterioides fragilis''<br />
+
**[[3ig2]] – PheRS β chain – ''Bacterioides fragilis''<br />
 +
**[[7daw]] – MtPheRS + α+β chains <br />
 +
**[[6p24]] – EcPheRS + α+β chains <br />
 +
**[[7n8y]] - SePheRS + chains – ''Salmonella enterica''<br />
* ''Phe-RS + small substrates or analogs''
* ''Phe-RS + small substrates or analogs''
 +
**[[3hfv]] – hPheRS + Tyr<br />
**[[3hfv]] – hPheRS + Tyr<br />
**[[3teg]] – hPheRS + L-DOPA<br />
**[[3teg]] – hPheRS + L-DOPA<br />
**[[3pco]] – EcPheRS + phenylalanine+ AMP <br />
**[[3pco]] – EcPheRS + phenylalanine+ AMP <br />
-
**[[3hfz]], [[2amc]] – TtPheRS + chains + Tyr<br />
+
**[[6oz5]], [[6p26]] – EcPheRS α+β chains + inhibitor<br />
-
**[[2akw]], [[1b70]] - TtPheRS + chains + Phe<br />
+
**[[3hfz]], [[2amc]] – TtPheRS α+β chains + Tyr<br />
-
**[[4tva]] - TtPheRS + chains + Phe + puromycin<br />
+
**[[2akw]], [[1b70]] - TtPheRS α+β chains + Phe<br />
-
**[[3teh]] - TtPheRS + chains + L-DOPA<br />
+
**[[4tva]] - TtPheRS α+β chains + Phe + puromycin<br />
-
**[[1jjc]], [[1b7y]] - TtPheRS + chains + Phe-adenylate<br />
+
**[[3teh]] - TtPheRS α+β chains + L-DOPA<br />
-
**[[2aly]] - TtPheRS + chains + Phe-SA<br />
+
**[[1jjc]], [[1b7y]] - TtPheRS α+β chains + Phe-adenylate<br />
-
**[[2rhq]], [[2rhs]] – PheRS + chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''<br />
+
**[[2aly]] - TtPheRS α+β chains + Phe-SA<br />
-
**[[4p72]], [[4p73]], [[4p74]], [[4p75]] – PaPheRS + chains + inhibitor<br />
+
**[[2rhq]], [[2rhs]] – PheRS α+β+ chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''<br />
 +
**[[4p72]], [[4p73]], [[4p74]], [[4p75]] – PaPheRS α+β chains + inhibitor<br />
 +
**[[7db7]], [[7db8]] – MtPheRS α+β chains + inhibitor<br />
 +
**[[6p8t]] – AbPheRS α+β chains + inhibitor<br />
 +
**[[7dpi]] – PfPheRS + α+β chains + inhibitor<br />
* ''Phe-RS + tRNA''
* ''Phe-RS + tRNA''
 +
**[[3tup]] – hPheRS + Phe-tRNA<br />
**[[3tup]] – hPheRS + Phe-tRNA<br />
-
**[[1eiy]] - TtPheRS + chains + Phe-tRNA<br />
+
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br />
-
**[[2iy5]] - TtPheRS + chains + Phe-ol + Phe-tRNA<br />
+
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA<br />
 +
**[[7k98]], [[7k9m]], [[7ka0]] - MtPheRS + chains + Phe-tRNA + Phe-AMS<br />
 +
**[[7kab]] - MtPheRS + chains + Phe-tRNA + Phe<br />
*'''Pro-RS'''
*'''Pro-RS'''
Line 548: Line 640:
**[[1nj2]] - MtProRS –'' Methanothermobacter thermautotrophicus''<br />
**[[1nj2]] - MtProRS –'' Methanothermobacter thermautotrophicus''<br />
**[[1nj8]] – MjProRS<br />
**[[1nj8]] – MjProRS<br />
-
**[[5xif]] – TgProRS residues 334-830 <br />
+
**[[5xif]], [[6aa0]] – TgProRS residues 334-830 <br />
**[[5ucm]] – PaProRS <br />
**[[5ucm]] – PaProRS <br />
**[[4twa]], [[4ncx]] – PfProRS residues 249-746 <br />
**[[4twa]], [[4ncx]] – PfProRS residues 249-746 <br />
* ''Pro-RS + small substrates or analogs''
* ''Pro-RS + small substrates or analogs''
 +
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
Line 560: Line 653:
**[[1h4t]] - TtProRS + Pro<br />
**[[1h4t]] - TtProRS + Pro<br />
**[[5ifu]] – PfProRS residues 249-746 + glyburide <br />
**[[5ifu]] – PfProRS residues 249-746 + glyburide <br />
-
**[[4wi1]] – PfProRS residues 249-746 + inhibitor<br />
+
**[[4wi1]], [[6t7k]], [[7qc1]] – PfProRS residues 249-746 + inhibitor<br />
*''Pro-RS ternary complex''
*''Pro-RS ternary complex''
 +
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br />
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br />
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br />
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br />
Line 571: Line 665:
**[[5f9y]] – CpProRS residues 186-688 + proline + AMP<br />
**[[5f9y]] – CpProRS residues 186-688 + proline + AMP<br />
**[[5xio]] – CpProRS residues 225-719 + halofuginone + ANP <br />
**[[5xio]] – CpProRS residues 225-719 + halofuginone + ANP <br />
-
**[[6nab]] - ProRS + Pro + AMP – Naegleria fowleri<br />
+
**[[5znj]] – SaProRS + halofuginone + ANP <br />
 +
**[[5znk]] – SaProRS + inhibitor + ANP <br />
 +
**[[6nab]] - NfProRS + Pro + AMP – ''Naegleria fowleri''<br />
 +
**[[6uyh]] – NfProRS + halofuginone + ANP <br />
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br />
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br />
-
**[[5xik]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br />
+
**[[7evu]], [[7f9u]], [[7f9v]] – TgProRS residues 215-711 + halofuginone + inhibitor <br />
 +
**[[7f9r]] – TgProRS residues 215-711 + febrifugine + inhibitor + Pro<br />
 +
**[[7evv]], [[7fal]] – TgProRS residues 215-711 + inhibitor + Pro <br />
 +
**[[5xik]], [[6a88]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br />
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br />
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br />
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br />
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br />
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br />
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br />
 +
**[[7qb7]], [[7qc2]] – PfProRS residues 249-746 + inhibitor + Pro <br />
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase)
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase)
-
**[[4hvc]] – hEPRS residues 1003-1513 + halofunginone + ATP analog<br />
+
**[[4hvc]] – hGlu/ProRS residues 1003-1513 + halofunginone + ATP analog<br />
-
**[[5v58]] – hEPRS residues 1003-1513 + AZ-SA<br />
+
**[[5v58]] – hGlu/ProRS residues 1003-1513 + AZ-SA<br />
-
**[[5vad]] – hEPRS residues 1003-1513 + inhibitor<br />
+
**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br />
-
**[[5a1n]], [[5a34]], [[5a5h]] – hEPRS GST-like domain + EPRS-AIMP2<br />
+
**[[7osy]] – hGlu/ProRS residues 1003-1513 + Pro<br />
 +
**[[7bbu]], [[7f98]], [[7f99]], [[7f9a]], [[7f9b]], [[7f9c]], [[7f9d]], [[7osz]], [[7ot0]], [[7ot1]], [[7ot2]], [[7ot3]] – hGlu/ProRS residues 1003-1513 + inhibitor + Pro<br />
 +
**[[7x09]], [[7x1o]] – hGlu/ProRS residues 1003-1513 + inhibitor + halofuginone<br />
 +
**[[7y1w]], [[7y28]], [[7y3s]] – hGlu/ProRS residues 1003-1513 + inhibitor + ATP<br />
 +
**[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain 1-175 + EPRS-AIMP2<br />
 +
**[[1fyj]] – hGlu/ProRS 677-733 – NMR<br />
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454
Line 590: Line 696:
**[[3vqw]], [[3vqx]], [[4cs2]] - MmPylRS catalytic domain (mutant)<br />
**[[3vqw]], [[3vqx]], [[4cs2]] - MmPylRS catalytic domain (mutant)<br />
**[[3dsq]] – DhPylRS<br />
**[[3dsq]] – DhPylRS<br />
-
**[[6ezd]] – PylRS – ''Methanomethylophilus alvus''<br />
+
**[[6ezd]], [[6jp2]] – PylRS – ''Methanomethylophilus alvus''<br />
 +
**[[7r6o]] - PylRS 1-273 – ''Methanogenic archaeon"<br />
*''Pyrrolysyl-RS binary complex''
*''Pyrrolysyl-RS binary complex''
Line 615: Line 722:
**[[4tqd]] - MmPylRS catalytic domain + iodo-Phe + ATP <br />
**[[4tqd]] - MmPylRS catalytic domain + iodo-Phe + ATP <br />
**[[4tqf]], [[4zib]] - MmPylRS catalytic domain + bromothienylo-Ala + ATP <br />
**[[4tqf]], [[4zib]] - MmPylRS catalytic domain + bromothienylo-Ala + ATP <br />
 +
**[[6ly3]], [[6ly6]], [[6lyb]] - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP <br />
 +
**[[6ly7]], [[6lya]] - MmPylRS catalytic domain (mutant) + Trp derivative + ANP <br />
 +
**[[7rsm]] - MmPylRS catalytic domain (mutant) + Phe derivative + ANP <br />
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br />
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br />
 +
**[[6aac]], [[6aad]], [[6aao]], [[6aap]], [[6aaz]], [[6ab0]], [[6ab1]], [[6ab2]], [[6ab8]], [[6abk]], [[6abl]], [[6abm]], [[6aan]], [[6anq]] - MmPylRS catalytic domain + azanyl derivative + ATP <br />
*'''Ser-RS'''
*'''Ser-RS'''
**[[3vbb]] - hSerRS <br />
**[[3vbb]] - hSerRS <br />
 +
**[[6gir]] - SerRS – ''Arabidopsis thaliana'' <br />
**[[3lsq]] – TbSerRS <br />
**[[3lsq]] – TbSerRS <br />
**[[1sry]] - TtSerRS<br />
**[[1sry]] - TtSerRS<br />
Line 627: Line 739:
**[[2dq3]] – AaSerRS<br />
**[[2dq3]] – AaSerRS<br />
**[[2du7]] – MjSerRS<br />
**[[2du7]] – MjSerRS<br />
-
**[[2odr]] – SerRS – ''Methanococcus maripaludis''<br />
+
**[[2odr]] – MemSerRS – ''Methanococcus maripaludis''<br />
**[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
**[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
-
**[[1wle]] – SerRS – bovine<br />
 
-
**[[6gir]] - SerRS – ''Arabidopsis thaliana'' <br />
 
**[[3qne]], [[3qo5]], [[3qo7]], [[3qo8]] - CaSerRS <br />
**[[3qne]], [[3qo5]], [[3qo7]], [[3qo8]] - CaSerRS <br />
* ''Ser-RS + small substrates or analogs''
* ''Ser-RS + small substrates or analogs''
**[[4l87]] - hSerRS + Ser-SA<br />
**[[4l87]] - hSerRS + Ser-SA<br />
 +
**[[1wle]] – bSerRS + Ser-adenylate - bovine<br />
**[[2zr2]] – PhSerRS + ATP<br />
**[[2zr2]] – PhSerRS + ATP<br />
**[[2dq0]] – PhSerRS + Ser-SA<br />
**[[2dq0]] – PhSerRS + Ser-SA<br />
Line 641: Line 752:
**[[2cja]] – MbSerRS + ATP<br />
**[[2cja]] – MbSerRS + ATP<br />
**[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br />
**[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br />
 +
**[[6r1m]], [[6r1n]] – SaSerRS + Ser-SA<br />
 +
**[[6hdz]], [[6he1]], [[6hhy]], [[6hi0]] – PaSerRS + Ser-SU<br />
 +
**[[6he3]], [[6hhz]] – PaSerRS + Ser-SC<br />
 +
**[[6r1o]] – EcSerRS + Ser-SA<br />
 +
**[[6h9x]] – KpSerRS + Ser-SA<br />
 +
**[[7ap1]] – KpSerRS + inhibitor<br />
 +
**[[6ote]] – CpSerRS + Ser-SA<br />
 +
**[[6x94]] – MmSerRS + Ser-SA<br />
* ''Ser-RS + tRNA''
* ''Ser-RS + tRNA''
Line 653: Line 772:
**[[2du3]], [[5x6c]] – AfPSerRS + Cys-tRNA + phosphoserine<br />
**[[2du3]], [[5x6c]] – AfPSerRS + Cys-tRNA + phosphoserine<br />
**[[2du5]], [[2du6]] - AfPSerRS (mutant) + Cys-tRNA + phosphoserine<br />
**[[2du5]], [[2du6]] - AfPSerRS (mutant) + Cys-tRNA + phosphoserine<br />
 +
**[[2odr]] - MemPSerRS <br />
*'''Thr-RS'''
*'''Thr-RS'''
Line 658: Line 778:
**[[1wwt]] – hThrRS TGS domain – NMR<br />
**[[1wwt]] – hThrRS TGS domain – NMR<br />
**[[3ugq]], [[3ugt]] - yThrRS <br />
**[[3ugq]], [[3ugt]] - yThrRS <br />
-
**[[1y2q]] - PaThrRS editing domain<br />
+
**[[1y2q]] - PabThrRS editing domain 1-143<br />
-
**[[1tje]] - EcThrRS editing domain<br />
+
**[[1tje]] - EcThrRS editing domain 1-224<br />
 +
**[[7l3o]] RBD 330-763 - CpThrRS <br />
* ''Thr-RS + small substrates or analogs''
* ''Thr-RS + small substrates or analogs''
-
**[[4p3n]] - hThrRS editing domain + borrelidin<br />
+
**[[4p3n]] - hThrRS editing domain 322-723 + borrelidin<br />
**[[4hws]] - hThrRS editing domain + inhibitor<br />
**[[4hws]] - hThrRS editing domain + inhibitor<br />
**[[3uh0]] - yThrRS editing domain + Thr-SA<br />
**[[3uh0]] - yThrRS editing domain + Thr-SA<br />
**[[4eo4]] - yThrRS editing domain + Ser-SA<br />
**[[4eo4]] - yThrRS editing domain + Ser-SA<br />
-
**[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br />
+
**[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PabThrRS editing domain + aa-aminoadenosine<br />
-
**[[2hkz]] – PaThrRS editing domain + Ser<br />
+
**[[2hkz]] – PabThrRS editing domain + Ser<br />
-
**[[2hl0]], [[2hl1]] - PaThrRS editing domain + Ser-adenylate<br />
+
**[[2hl0]], [[2hl1]] - PabThrRS editing domain + Ser-adenylate<br />
-
**[[2hl2]] - PaThrRS editing domain + Ser-SA<br />
+
**[[2hl2]] - PabThrRS editing domain + Ser-SA<br />
**[[1tke]] - EcThrRS editing domain + Ser<br />
**[[1tke]] - EcThrRS editing domain + Ser<br />
**[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
**[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
Line 684: Line 805:
**[[4rrf]] - MjThrRS editing domain + Ser<br />
**[[4rrf]] - MjThrRS editing domain + Ser<br />
**[[4rrg]] - MjThrRS editing domain + Thr<br />
**[[4rrg]] - MjThrRS editing domain + Thr<br />
 +
**[[6l2q]], [[7cbg]], [[7cbi]], [[7cbh]], [[7wm7]], [[7wmf]], [[7wmi]] - SeThrRS 222-622 + inhibitor <br />
* ''Thr-RS + tRNA''
* ''Thr-RS + tRNA''
Line 691: Line 813:
**[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA<br />
**[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA<br />
-
*'''Multifunctional RS'''
 
- 
-
**[[1fyj]] – hRS – NMR<br />
 
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

3D Structures of Aminoacyl tRNA Synthetase

Updated on 24-September-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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