User:Josephine Thestrup/Sandbox 1

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= Introduction=
= Introduction=
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<scene name='81/811087/Active_site_loop_1_s30-k36/13'>Ser39</scene>
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= Function =
= Function =
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<scene name='81/811087/Active_site_hdac8/1'>Active</scene>
<scene name='81/811087/Active_site_hdac8/1'>Active</scene>
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<scene name='81/811087/Active_site_loop_1_s30-k36/1'>Active loop site</scene>
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<scene name='81/811087/Active_site_loop_1_s30-k36/4'>N-Terminus L1 loop</scene>
<scene name='81/811087/Asp_to_the_ligand/1'>The crucial Asp 101 interacting with the ligand at the rim of the active site</scene>
<scene name='81/811087/Asp_to_the_ligand/1'>The crucial Asp 101 interacting with the ligand at the rim of the active site</scene>
= Inhibitors =
= Inhibitors =
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<scene name='81/811087/Ligand_interaction/2'>Asp101, Phe152 and Phe208</scene>
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 +
 +
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<scene name='81/811087/Active_site_loop_1_s30-k36/10'>Ser39</scene>
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= Medical relevance =
= Medical relevance =
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<scene name='81/811087/Inhibitor_and_zinc_binding/1'>Text To Be Displayed</scene>
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<scene name='81/811087/Inhibitor_and_zinc_binding/2'>Compound 1 (HDAC class 1 hydroxamic acid inhibitor) binding to the Zn2+ in a bidentate fashion</scene>
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
</StructureSection>
</StructureSection>
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<scene name='81/811087/Inhibitor_and_zinc_binding/4'>His142,His143 and Tyr306</scene>
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<scene name='81/811087/Inhibitor_and_zinc_binding/9'>at the active site of HDAC8</scene>
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<scene name='81/811087/Active_site_loop_1_s30-k36/11'>N-Terminus L1 loop</scene>
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<scene name='81/811087/Active_site_loop_1_s30-k36/12'>Ser39</scene>
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<scene name='81/811087/Inhibitor_and_zinc_binding/10'>Amino acid derived</scene>
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<scene name='81/811087/Inhibitor_and_zinc_binding/13'>binds to the zinc ion</scene>
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<scene name='81/811087/Potassium_ion/2'>potassium ions</scene>
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<scene name='81/811087/Ligand_interaction/4'>Asp101,Phe152 and Phe208</scene>
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<scene name='81/811087/Ligand_interaction/5'>Asp101</scene>
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<scene name='81/811087/Active_site_loop_1_s30-k36/14'>N-Terminus L1 loop</scene>
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<scene name='81/811087/Potassium_ion/4'>Asp178 and His180</scene>
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== References ==
== References ==
<references/>
<references/>

Current revision

Histone Deacetylase 8 from Homo Sapiens

This is a default text for your page Josephine Thestrup/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.

Human Histone Deacetylase 8 homodimer,pdb:2v5w

Drag the structure with the mouse to rotate

Contents

Introduction


Function

Structural highlights

HDAC 8 structure overview
HDAC 8 structure overview

Enzymatic mechanism

Inhibitors



Medical relevance

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

</StructureSection>






References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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Josephine Thestrup

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