6oa3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human PARG complexed with JA2131== | |
| + | <StructureSection load='6oa3' size='340' side='right'caption='[[6oa3]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6oa3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OA3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=M0M:(8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one'>M0M</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oa3 OCA], [https://pdbe.org/6oa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oa3 RCSB], [https://www.ebi.ac.uk/pdbsum/6oa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oa3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PARG_HUMAN PARG_HUMAN] Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers. Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters.<ref>PMID:23102699</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Poly(ADP-ribose) glycohydrolase 3D structures|Poly(ADP-ribose) glycohydrolase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Ellenberger | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Kim | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Tainer | + | [[Category: Ellenberger T]] |
| + | [[Category: Jones DE]] | ||
| + | [[Category: Kim IK]] | ||
| + | [[Category: Stegeman RA]] | ||
| + | [[Category: Tainer JA]] | ||
Current revision
Structure of human PARG complexed with JA2131
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