6r9l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A quadruplex hybrid structure with lpp loop orientation and 5 syn residues== | |
| + | <StructureSection load='6r9l' size='340' side='right'caption='[[6r9l]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6r9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R9L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9l OCA], [https://pdbe.org/6r9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r9l RCSB], [https://www.ebi.ac.uk/pdbsum/6r9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The oligomer d(GCGTG3 TCAG3 TG3 TG3 ACGC) with short complementary flanking sequences at the 5'- and 3'-ends was shown to fold into three different DNA G-quadruplex species. In contrast, a corresponding oligomer that lacks base complementarity between the two overhang sequences folds into a single parallel G-quadruplex. The three coexisting quadruplex structures were unambiguously identified and structurally characterized through detailed spectral comparisons with well-defined G-quadruplexes formed upon the deliberate incorporation of syn-favoring 8-bromoguanosine analogues into specific positions of the G-core. Two (3+1) hybrid structures coexist with the parallel fold and feature a novel lateral-propeller-propeller loop architecture that has not yet been confirmed experimentally. Both hybrid quadruplexes adopt the same topology and only differ in their pattern of anti-->syn transitions and tetrad stackings. | ||
| - | + | Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.,Karg B, Mohr S, Weisz K Angew Chem Int Ed Engl. 2019 May 28. doi: 10.1002/anie.201905372. PMID:31134741<ref>PMID:31134741</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Karg | + | <div class="pdbe-citations 6r9l" style="background-color:#fffaf0;"></div> |
| - | [[Category: Weisz | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Karg B]] | ||
| + | [[Category: Weisz K]] | ||
Current revision
A quadruplex hybrid structure with lpp loop orientation and 5 syn residues
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