6iji

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<StructureSection load='6iji' size='340' side='right'caption='[[6iji]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='6iji' size='340' side='right'caption='[[6iji]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6iji]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IJI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6iji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IJI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEL:2-{2-[5-methyl-1-(pyridin-4-yl)-1H-benzimidazol-2-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione'>AEL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iji OCA], [http://pdbe.org/6iji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iji RCSB], [http://www.ebi.ac.uk/pdbsum/6iji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iji ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEL:2-{2-[5-methyl-1-(pyridin-4-yl)-1H-benzimidazol-2-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione'>AEL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iji OCA], [https://pdbe.org/6iji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iji RCSB], [https://www.ebi.ac.uk/pdbsum/6iji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iji ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6iji" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6iji" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Huang, Y Y]]
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[[Category: Huang YY]]
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[[Category: Luo, H B]]
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[[Category: Luo HB]]
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[[Category: Wu, D]]
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[[Category: Wu D]]
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[[Category: Wu, Y]]
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[[Category: Wu Y]]
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[[Category: Yu, Y F]]
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[[Category: Yu YF]]
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[[Category: Zhang, C]]
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[[Category: Zhang C]]
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[[Category: Hydrolase-inhibitor complex]]
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Current revision

Crystal structure of PDE10 in complex with inhibitor 2b

PDB ID 6iji

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OCA

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