4n6q

Structural highlights

Function

VOSA_EMENI Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (PubMed:17912349, PubMed:21152013, PubMed:23049895, PubMed:24391470). Controls primarily the late process of sporulation including trehalose biogenesis (PubMed:17912349). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (PubMed:24391470). The vosA-velB complex binds to the beta-glucan synthase fksA gene promoter in asexual spores for repression (PubMed:25960370).[UniProtKB:A0SP16]^{[1] [2] [3] [4]}

References

1. ↑ Ni M, Yu JH. A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PLoS One. 2007 Oct 3;2(10):e970. doi: 10.1371/journal.pone.0000970. PMID:17912349 doi:http://dx.doi.org/10.1371/journal.pone.0000970
2. ↑ Sarikaya Bayram O, Bayram O, Valerius O, Park HS, Irniger S, Gerke J, Ni M, Han KH, Yu JH, Braus GH. LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet. 2010 Dec 2;6(12):e1001226. doi: 10.1371/journal.pgen.1001226. PMID:21152013 doi:http://dx.doi.org/10.1371/journal.pgen.1001226
3. ↑ Park HS, Ni M, Jeong KC, Kim YH, Yu JH. The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans. PLoS One. 2012;7(9):e45935. doi: 10.1371/journal.pone.0045935. Epub 2012 Sep 25. PMID:23049895 doi:http://dx.doi.org/10.1371/journal.pone.0045935
4. ↑ Park HS, Man Yu Y, Lee MK, Jae Maeng P, Chang Kim S, Yu JH. Velvet-mediated repression of beta-glucan synthesis in Aspergillus nidulans spores. Sci Rep. 2015 May 11;5:10199. doi: 10.1038/srep10199. PMID:25960370 doi:http://dx.doi.org/10.1038/srep10199