6oik
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6oik is ON HOLD Authors: Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B. Description: GPCR complex 2 Category: Unreleased Structures [[Categ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Muscarinic acetylcholine receptor 2-Go complex== | |
| + | <SX load='6oik' size='340' side='right' viewer='molstar' caption='[[6oik]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6oik]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OIK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2CU:3-AMINO-5-CHLORO-N-CYCLOPROPYL-4-METHYL-6-[2-(4-METHYLPIPERAZIN-1-YL)-2-OXOETHOXY]THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE'>2CU</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oik OCA], [https://pdbe.org/6oik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oik RCSB], [https://www.ebi.ac.uk/pdbsum/6oik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oik ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACM2_HUMAN ACM2_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Muscarinic acetylcholine receptors are G protein-coupled receptors that respond to acetylcholine and play important signaling roles in the nervous system. There are five muscarinic receptor subtypes (M1R to M5R), which, despite sharing a high degree of sequence identity in the transmembrane region, couple to different heterotrimeric GTP-binding proteins (G proteins) to transmit signals. M1R, M3R, and M5R couple to the Gq/ 11 family, whereas M2R and M4R couple to the Gi/ o family. Here, we present and compare the cryo-electron microscopy structures of M1R in complex with G11 and M2R in complex with GoA The M1R-G11 complex exhibits distinct features, including an extended transmembrane helix 5 and carboxyl-terminal receptor tail that interacts with G protein. Detailed analysis of these structures provides a framework for understanding the molecular determinants of G-protein coupling selectivity. | ||
| - | + | Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.,Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK Science. 2019 May 10;364(6440):552-557. doi: 10.1126/science.aaw5188. PMID:31073061<ref>PMID:31073061</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6oik" style="background-color:#fffaf0;"></div> |
| - | [[Category: Maeda | + | |
| - | [[Category: Qianhui | + | ==See Also== |
| - | [[Category: | + | *[[Antibody 3D structures|Antibody 3D structures]] |
| + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | ||
| + | *[[Muscarinic acetylcholine receptor|Muscarinic acetylcholine receptor]] | ||
| + | *[[Transducin 3D structures|Transducin 3D structures]] | ||
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Kobilka B]] | ||
| + | [[Category: Maeda S]] | ||
| + | [[Category: Qianhui Q]] | ||
| + | [[Category: Skiniotis G]] | ||
Current revision
Muscarinic acetylcholine receptor 2-Go complex
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