6nig

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:28, 21 November 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 3: Line 3:
<StructureSection load='6nig' size='340' side='right'caption='[[6nig]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='6nig' size='340' side='right'caption='[[6nig]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6nig]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NIG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NIG FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6nig]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Eptatretus_stoutii Eptatretus stoutii] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NIG FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KQD:(3S,4S,3S,4S)-1,1-(1,4-phenylenedicarbonyl)bis{N~3~,N~4~-bis[(1S,2R)-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxamide}'>KQD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nig OCA], [http://pdbe.org/6nig PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nig RCSB], [http://www.ebi.ac.uk/pdbsum/6nig PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nig ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KQD:(3~{S},4~{S})-1-[4-[(3~{S},4~{S})-3,4-bis[[(1~{S},2~{R})-2-phenylcyclopropyl]carbamoyl]pyrrolidin-1-yl]carbonylphenyl]carbonyl-~{N}3,~{N}4-bis[(1~{S},2~{R})-2-phenylcyclopropyl]pyrrolidine-3,4-dicarboxamide'>KQD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nig OCA], [https://pdbe.org/6nig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nig RCSB], [https://www.ebi.ac.uk/pdbsum/6nig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nig ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN]] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.
+
[https://www.uniprot.org/uniprot/TLR2_HUMAN TLR2_HUMAN] Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.[https://www.uniprot.org/uniprot/Q2YE02_EPTST Q2YE02_EPTST]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 6nig" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6nig" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
 +
*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Eptatretus stoutii]]
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Beutler, B A]]
+
[[Category: Beutler BA]]
-
[[Category: Su, L]]
+
[[Category: Su L]]
-
[[Category: Tomchick, D R]]
+
[[Category: Tomchick DR]]
-
[[Category: Zhang, H]]
+
[[Category: Zhang H]]
-
[[Category: Immune system-agonist complex]]
+
-
[[Category: Innate immune agonist]]
+
-
[[Category: Toll-like receptor]]
+

Current revision

Crystal structure of the human TLR2-Diprovocim complex

PDB ID 6nig

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6nig"
Personal tools