This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4ppr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:20, 20 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='4ppr' size='340' side='right'caption='[[4ppr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4ppr' size='340' side='right'caption='[[4ppr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4ppr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PPR FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4ppr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PPR FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MER:(4R,5S)-3-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-5-[(2S,3R)-3-HYDROXY-1-OXOBUTAN-2-YL]-4-METHYL-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>MER</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p0m|4p0m]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MER:(4R,5S)-3-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-5-[(2S,3R)-3-HYDROXY-1-OXOBUTAN-2-YL]-4-METHYL-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>MER</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rv3330, RVBD_3330 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ppr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppr OCA], [https://pdbe.org/4ppr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ppr RCSB], [https://www.ebi.ac.uk/pdbsum/4ppr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppr ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ppr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ppr OCA], [http://pdbe.org/4ppr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ppr RCSB], [http://www.ebi.ac.uk/pdbsum/4ppr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ppr ProSAT]</span></td></tr>
+
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/DACB1_MYCTU DACB1_MYCTU] Probably cleaves the terminal D-Ala-D-Ala dipeptide of the peptidoglycan stem peptide (Probable). Shows weak D,D-carboxypeptidase activity in vitro (PubMed:22906310). Acts on the synthetic penta-peptide substrate Penta-DAP (L-Ala-gamma-D-Gln-DAP-D-Ala-D-Ala) (PubMed:22906310). The catalytic domain binds weakly to peptidoglycan in vitro (PubMed:25551456).<ref>PMID:22906310</ref> <ref>PMID:25551456</ref> <ref>PMID:22906310</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 19:
</div>
</div>
<div class="pdbe-citations 4ppr" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ppr" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 23: Line 27:
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Myctu]]
+
[[Category: Mycobacterium tuberculosis H37Rv]]
-
[[Category: Alber, T]]
+
[[Category: Alber T]]
-
[[Category: Huizar, J P]]
+
[[Category: Huizar JP]]
-
[[Category: Mavrici, D]]
+
[[Category: Mavrici D]]
-
[[Category: Prigozhin, D M]]
+
[[Category: Prigozhin DM]]
-
[[Category: Structural genomic]]
+
-
[[Category: D-peptidase]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: National institute of allergy and infectious disease]]
+
-
[[Category: Niaid]]
+
-
[[Category: Penicillin-binding protein]]
+
-
[[Category: Peptidoglycan d]]
+
-
[[Category: Tbsgc]]
+

Current revision

Crystal structure of Mycobacterium tuberculosis D,D-peptidase Rv3330 in complex with meropenem

PDB ID 4ppr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4ppr"
Personal tools