Calcineurin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Calcineurin''' (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. | + | '''Calcineurin''' (CN) is a eukaryotic calcium-dependent '''serine/threonine protein phosphatase 2B''' which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. |
For more details see [[Group:MUZIC:Calcineurin]]. | For more details see [[Group:MUZIC:Calcineurin]]. | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of calcineurin== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | [[1tco]] – CN subunit A, B + FK-506-binding protein + Ca + Fe + Zn – bovine<br /> | ||
| - | [[1aui]] - hCN subunit A, B + Ca + Fe + Zn – human<br /> | ||
| - | [[4il1]] – CN subunit A, B/calmodulin + Ca – rat<br /> | ||
| - | [[1m63]], [[1mf8]] - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn<br /> | ||
| - | [[2p6b]] - hCN subunit A, B + PVIVIT peptide + Ca + Fe + Zn<br /> | ||
| - | [[3ll8]] - hCN subunit A, B + AKAP79 peptide + Ca + Fe + Zn<br /> | ||
| - | [[2jog]] - hCN subunit A + NFAT peptide<br /> | ||
| - | [[5c1v]] – hCN subunit A residues 2-347 (mutant) + Fe + Zn<br /> | ||
| - | [[2w73]], [[2jzi]] - hCN subunit A calmodulin-binding domain + calmodulin + Ca<br /> | ||
| - | [[4f0z]] – hCN subunit B + African swine protein virus + Ca<br /> | ||
| - | [[4or9]], [[4ora]], [[4orb]], [[4orc]] – hCN subunit B + serine/threonine protein phosphatase + Ca + Fe + Zn <br /> | ||
| - | [[5b8i]] – hCN subunit B + serine/threonine protein phosphatase + peptidyl-prolyl cis-trans isomerase + Ca + Fe + Zn <br /> | ||
| - | [[5sve]] – hCN subunit B + serine/threonine protein phosphatase + NAFTC1 LXVP peptide + Ca + Fe + Zn <br /> | ||
==References== | ==References== | ||
Current revision
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References
- ↑ Kissinger CR, Parge HE, Knighton DR, Lewis CT, Pelletier LA, Tempczyk A, Kalish VJ, Tucker KD, Showalter RE, Moomaw EW, et al.. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature. 1995 Dec 7;378(6557):641-4. PMID:8524402 doi:http://dx.doi.org/10.1038/378641a0
