CAMP-dependent protein kinase
From Proteopedia
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<StructureSection load='1xh6' size='350' side='right' scene='46/468128/Cv/1' caption='Bovine PKA catalytic subunit (magenta) complex with PKA inhibitor (green) and nicotinamide derivative (PDB code [[1xh6]])'> | <StructureSection load='1xh6' size='350' side='right' scene='46/468128/Cv/1' caption='Bovine PKA catalytic subunit (magenta) complex with PKA inhibitor (green) and nicotinamide derivative (PDB code [[1xh6]])'> | ||
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== Function == | == Function == | ||
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* [[Eukaryotic Protein Kinase Catalytic Domain]] | * [[Eukaryotic Protein Kinase Catalytic Domain]] | ||
* [[Protein Kinase A]]. | * [[Protein Kinase A]]. | ||
| + | * [[CAMP-dependent pathway]]. | ||
| + | * [[CAMP is second messenger]]. | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of cAMP-dependent protein kinase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''PKA catalytic subunit''' | ||
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| - | **[[1j3h]] – mPKA – mouse | ||
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| - | **[[1syk]], [[4dfy]], [[4nts]] - mPKA (mutant) | ||
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| - | **[[1fot]] - yPKA – yeast<br /> | ||
| - | **[[4ae6]], [[4ae9]] – hPKA 2 – human<br /> | ||
| - | **[[6eh0]] – haPKA – hamster<br /> | ||
| - | |||
| - | *PKA catalytic subunit binary complex | ||
| - | |||
| - | **[[4ntt]] – mPKA (mutant) + ADP<br /> | ||
| - | **[[5n1f]], [[5n1g]], [[5n1h]], [[5n3g]], [[5n3h]], [[5n3i]], [[5n3j]], [[5n3k]], [[5n3l]], [[5n3m]], [[5n3n]], [[5n3o]], [[5n3p]], [[5n3q]], [[5n3r]], [[5n3s]], [[5n3t]] - haPKA + fragment molecule<br /> | ||
| - | **[[6em2]] - haPKA + fasudil<br /> | ||
| - | **[[6c0u]] - hPKA + inhibitor<br /> | ||
| - | **[[3bwj]] - bPKA + bisubstrate inhibitor<br /> | ||
| - | **[[3agl]], [[3agm]] – hPKA + bisubstrate inhibitor<br /> | ||
| - | **[[1bkx]] – mPKA + adenosine<br /> | ||
| - | **[[3o7l]] – mPKA + phospholamban<br /> | ||
| - | **[[1bx6]], [[1re8]], [[1rej]], [[1rek]] - mPKA + balanol analog<br /> | ||
| - | **[[1szm]] - bPKA + bisindolymaleimide<br /> | ||
| - | **[[3ag9]] - bPKA + inhibitor<br /> | ||
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| - | *PKA catalytic subunit binary complex with peptide inhibitor | ||
| - | |||
| - | **[[2cpk]], [[1ctp]], [[1fmo]], [[1l3r]], [[1xh4]], [[1xh5]], [[1xh6]], [[1xh7]], [[1xh8]], [[1xh9]], [[1xha]], [[3fjq]], [[4dg0]], [[4dg2]], [[4dh1]], [[4dh3]], [[4dh5]], [[4dh7]], [[4dh8]], [[4hpt]], [[4hpu]], [[4xw6]], [[4xw5]], [[4xw4]], [[3x2w]], [[3x2v]], [[3x2u]] – mPKA + peptide inhibitor<br /> | ||
| - | **[[1q61]], [[1q62]], [[1smh]], [[2qur]], [[3qal]], [[3qam]], [[4dfx]], [[4dfz]], [[4dg3]] - mPKA (mutant) + peptide inhibitor<br /> | ||
| - | **[[4iac]], [[4iad]], [[4iaf]], [[4iai]], [[4iak]], [[4iay]], [[4iaz]], [[4ib0]], **[[4ib1]], [[4ib3]], [[4o22]] – mPKA + SP20 peptide<br /> | ||
| - | **[[2gfc]], [[3dnd]], [[3dne]], [[3kkv]], [[3zo1]], [[3zo2]], [[3zo3]], [[3zo4]], [[4ie9]], [[4ij9]], [[4yxs]], [[4yxr]] - bPKA + peptide inhibitor<br /> | ||
| - | **[[4wih]], [[5lcp]], [[5lcq]], [[5lcr]], [[5lct]], [[5lcu]], [[5m0u]] - haPKA + peptide inhibitor <br /> | ||
| - | **[[2gng]], [[4axa]], [[4c33]], [[4c34]], [[4c35]], [[4c36]], [[4c37]], [[4c38]] - bPKA (mutant) + peptide inhibitor<br /> | ||
| - | **[[3mvj]], [[3oog]], [[3poo]], [[3vqh]], [[5j5x]], [[5izj]], [[5izf]], [[5bx7]], [[5bx6]], [[4ujb]], [[4uja]], [[4uj9]], [[4uj2]], [[4uj1]] - hPKA + peptide inhibitor<br /> | ||
| - | **[[4z84]], [[4z83]] - hPKA (mutant) + peptide inhibitor<br /> | ||
| - | **[[4wb5]], [[4wb6]], [[4wb8]] – mPKA (mutant) + PKI peptide<br /> | ||
| - | **[[1cdk]] - pPKA + peptide inhibitor – pig<br /> | ||
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| - | *PKA catalytic subunit ternary complex | ||
| - | |||
| - | **[[1apm]], [[1jlu]] - mPKA + detergent + peptide inhibitor<br /> | ||
| - | **[[2erz]] - mPKA + peptide inhibitor + hydroxyfasudil<br /> | ||
| - | **[[1cmk]] - pPKA + peptide inhibitor + myristic acid<br /> | ||
| - | **[[1stc]] - bPKA + peptide inhibitor + saturosporine<br /> | ||
| - | **[[2gnh]], [[2gni]], [[2gnj]], [[2gnl]], [[2jdv]], [[2uvx]], [[2uvy]], [[2uvz]], [[2uw0]], [[2uw3]], [[2uw4]], [[2uw5]], [[2uw6]], [[2uw7]], [[2uw8]], [[2vnw]], [[2vny]], [[2vo0]], [[2vo3]], [[2vo6]], [[2vo7]] - bPKA (mutant) + peptide inhibitor + inhibitor<br /> | ||
| - | **[[1ydr]], [[1yds]], [[1ydt]], [[2c1a]], [[2c1b]], [[2oh0]], [[2ojf]], [[2uzt]], [[2uzu]], [[2uzv]], [[2uzw]], [[2f7e]], [[2f7x]], [[2f7z]], [[2jds]], [[5vib]] - bPKA + peptide inhibitor + inhibitor<br /> | ||
| - | **[[2jdt]], [[5vi9]] - bPKA (mutant) + peptide inhibitor + inhibitor<br /> | ||
| - | **[[3e8c]], [[3e8e]] - bPKA catalytic subunit + peptide inhibitor + ATP-competitive inhibitor<br /> | ||
| - | **[[1q8t]], [[1q8u]], [[1q8w]]- bPKA + peptide inhibitor + rho-kinase inhibitor<br /> | ||
| - | **[[2gnf]] - bPKA (mutant) + peptide inhibitor + rho-kinase inhibitor<br /> | ||
| - | **[[1sve]], [[1svg]], [[1svh]], [[1veb]] - bPKA + detergent + peptide inhibitor + azepane derivative<br /> | ||
| - | **[[2gu8]], [[3l9l]], [[3ovv]], [[3owp]], [[3oxt]], [[3p0m]], [[5uzk]] - hPKA catalytic subunit + peptide inhibitor + inhibitor<br /> | ||
| - | **[[3nx8]] - hPKA catalytic subunit + peptide inhibitor + phenol<br /> | ||
| - | **[[3l9m]], [[3l9n]], [[3ama]], [[3amb]] - hPKA (mutant) + peptide inhibitor + inhibitor<br /> | ||
| - | **[[3wyg]] – hPKA + GSP1P + exportin<br /> | ||
| - | **[[3ow3]] - mPKA catalytic subunit + peptide inhibitor + inhibitor<br /> | ||
| - | **[[5mhi]], [[5n1d]], [[5n1e]], [[5n1k]], [[5n1l]], [[5n1m]], [[5n1n]], [[5n1o]], [[5n32]], [[5n33]], [[5n36]], [[5n37]], [[5n39]], [[5n3a]], [[5n3b]], [[5n3c]], [[5n3d]], [[5n3e]], [[5n3f]], [[5n7p]], [[5n7u]] - haPKA + peptide inhibitor + fragment molecule<br /> | ||
| - | **[[6f14]], [[6frx]], [[6erv]], [[6eru]], [[6ert]], [[6eme]], [[6emd]], [[6emc]], [[6eh3]], [[6egw]], [[5ous]], [[5ouc]], [[5oua]], [[5otg]], [[5ot3]], [[5ol3]], [[5ok3]], [[5o5m]], [[5o0e]], [[5nw8]], [[5ntj]] - haPKA + peptide inhibitor + inhibitor<br /> | ||
| - | **[[6erw]], [[6ers]], [[6emb]], [[5m75]], [[5m71]], [[5m6y]], [[5m6v]], [[5m0l]], [[5m0c]], [[5m0b]] - haPKA + peptide inhibitor + fasudil derivative<br /> | ||
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| - | *PKA catalytic subunit ternary complex with nucleotide | ||
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| - | **[[1jbp]] - mPKA + detergent + peptide inhibitor + ADP<br /> | ||
| - | **[[1rdq]] - mPKA + peptide inhibitor + ADP + ATP<br /> | ||
| - | **[[4o21]] - mPKA + peptide inhibitor + ATP-G-S<br /> | ||
| - | **[[1atp]] - mPKA + peptide inhibitor + Mn-ATP<br /> | ||
| - | **[[1q24]] - bPKA + peptide inhibitor + Mg-ATP<br /> | ||
| - | **[[6ema]] - haPKA + peptide inhibitor + inhibitor + ATP<br /> | ||
| - | **[[6e21]] - mPKA + peptide inhibitor + ADP<br /> | ||
| - | **[[6em7]], [[6em6]] - haPKA + peptide inhibitor + inhibitor + ADP<br /> | ||
| - | **[[6eh2]] - haPKA + peptide inhibitor + inhibitor + AMP<br /> | ||
| - | **[[6esa]] - haPKA + peptide inhibitor + ribose + AMP<br /> | ||
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| - | *PKA regulatory subunit | ||
| - | |||
| - | **[[1cx4]] - rPKA II-β cAMP-binding domain – rat<br /> | ||
| - | **[[1r2a]] - mPKA II dimerization-anchoring domain – NMR<br /> | ||
| - | **[[1l6e]] - mPKA II-α dimerization-anchoring domain – NMR<br /> | ||
| - | **[[2ezw]] - bPKA I-α dimerization-anchoring domain – bovine - NMR<br /> | ||
| - | **[[1ne4]], [[1ne6]], [[1rl3]], [[3iia]], [[1rgs]], [[4mx3]] - bPKA <br /> | ||
| - | **[[3im3]] - bPKA I-α dimerization-anchoring domain<br /> | ||
| - | **[[3pna]] - bPKA I-α cAMP-binding domain<br /> | ||
| - | **[[3of1]] - yPKA <br /> | ||
| - | **[[4f9k]] – hPKA I-β<br /> | ||
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| - | *PKA regulatory subunit binary complex | ||
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| - | **[[2drn]], [[2h9r]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide – NMR<br /> | ||
| - | **[[2izx]], [[2izy]], [[4zp3]] - hPKA II-α + A-kinase anchoring protein peptide<br /> | ||
| - | **[[3im4]], [[5hvz]] - bPKA I-α + A-kinase anchoring protein peptide<br /> | ||
| - | **[[2hwn]] - rPKA II-α + A-kinase binding peptide<br /> | ||
| - | **[[4jva]] – rPKA II-β + cAMP analog<br /> | ||
| - | **[[4jv4]] – bPKA I-α + cAMP analog<br /> | ||
| - | **[[2kyg]] - hPKA II-α + CBFA2T1<br /> | ||
| - | **[[5kjx]] - hPKA I-α + cAMP<br /> | ||
| - | **[[5kjy]], [[5kjz]] - hPKA I-α (mutant) + cAMP<br /> | ||
| - | **[[3plq]] - bPKA I-α + cAMP derivative<br /> | ||
| - | **[[5t3n]] - PfPKA + cAMP derivative – ''Plasmodium falciparum''<br /> | ||
| - | **[[5kbf]], [[5k8s]] - PfPKA + cAMP <br /> | ||
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| - | *PKA regulatory subunit ternary complex | ||
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| - | **[[3tmh]] - rPKA II-α dimerization-anchoring domain + A-kinase anchoring protein peptide + NHERF-3<br /> | ||
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| - | *PKA catalytic and regulatory subunits | ||
| - | **[[6bys]] – hPKA<br /> | ||
| - | **[[2qvs]], [[3idb]], [[3idc]], [[3pvb]], [[4din]], [[4x6q]], [[4wbb]] - mPKA <br /> | ||
| - | **[[3fhi]], [[2qcs]], [[3tnp]], [[3tnq]], [[4x6r]] - mPKA (mutant) <br /> | ||
| - | **[[3j4q]], [[3j4r]] – mPKA + A-kinase anchor protein 18<br /> | ||
| - | **[[5jr7]] – m+bPKA + ADP<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Bastidas AC, Wu J, Taylor SS. Molecular Features of Product Release for the PKA Catalytic Cycle. Biochemistry. 2014 Aug 8. PMID:25077557 doi:http://dx.doi.org/10.1021/bi500684c
- ↑ Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs. ACS Chem Biol. 2013 Sep 10. PMID:23978166 doi:10.1021/cb400247t
