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Carbonic anhydrase 3D structures
From Proteopedia
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(New page: == 3D Structures of Carbonic anhydrase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| <br /> *'''α-carbonic an...) |
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| - | + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} - For a general description of the protein see [[Carbonic anhydrase]] | |
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | + | |
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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*'''α-carbonic anhydrase''' | *'''α-carbonic anhydrase''' | ||
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**[[5tt3]] – HpCA (mutant) + inhibitor <br /> | **[[5tt3]] – HpCA (mutant) + inhibitor <br /> | ||
**[[6gwu]] – CA – ''Candida albicans''<br /> | **[[6gwu]] – CA – ''Candida albicans''<br /> | ||
| - | **[[6eki]] – CA – ''Persephonella marina''<br /> | + | **[[6eki]], [[6im0]], [[6im1]], [[6im3]] – CA – ''Persephonella marina''<br /> |
**[[5ztp]] – CA – ''Glaciozyma antarctica''<br /> | **[[5ztp]] – CA – ''Glaciozyma antarctica''<br /> | ||
| + | **[[7o2s]] – SmCA – ''Schistosoma mansoni''<br /> | ||
| + | **[[7bm4]], [[7nex]], [[7ng1]], [[7nwy]], [[7o48]], [[7oa1]] – SmCA + sulfonamide derivative<br /> | ||
*''Carbonic anhydrase I'' | *''Carbonic anhydrase I'' | ||
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**[[1jv0]] – hCA1 (mutant) <br /> | **[[1jv0]] – hCA1 (mutant) <br /> | ||
**[[1j9w]] - hCA1 (mutant) – NMR<br /> | **[[1j9w]] - hCA1 (mutant) – NMR<br /> | ||
| - | **[[3lxe]], [[2it4]], [[2nn7]], [[2nmx]], [[2nn1]], [[1azm]], [[1bzm]], [[1czm]], [[1hug]], [[1huh]], [[4wr7]]. [[4wup]], [[4wuq]], [[5e2m]] – hCA1 + inhibitor<br /> | + | **[[3lxe]], [[2it4]], [[2nn7]], [[2nmx]], [[2nn1]], [[1azm]], [[1bzm]], [[1czm]], [[1hug]], [[1huh]], [[4wr7]]. [[4wup]], [[4wuq]], [[5e2m]], [[6i0l]] – hCA1 + inhibitor<br /> |
| - | **[[5gmm]] – hCA1 + NSAID drug<br /> | + | **[[5gmm]], [[7pif]] – hCA1 + NSAID drug<br /> |
**[[1hcb]] – hCA1 + bicarbonate<br /> | **[[1hcb]] – hCA1 + bicarbonate<br /> | ||
**[[2fw4]] – hCA1 + activator<br /> | **[[2fw4]] – hCA1 + activator<br /> | ||
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**[[6hwz]] – hCA1 + benzene derivative<br /> | **[[6hwz]] – hCA1 + benzene derivative<br /> | ||
**[[6g3v]] – hCA1 + famotidine<br /> | **[[6g3v]] – hCA1 + famotidine<br /> | ||
| + | **[[6swm]] – hCA1 + selenol<br /> | ||
**[[6faf]], [[6fag]], [[6f3b]] – hCA1 + urea derivative<br /> | **[[6faf]], [[6fag]], [[6f3b]] – hCA1 + urea derivative<br /> | ||
| - | **[[6ex1]], [[6evr]] – hCA1 + sulfonamide derivative<br /> | + | **[[6ex1]], [[6evr]], [[6xze]], [[6xzo]], [[6xzs]], [[6xzy]], [[6y00]], [[7q0d]] – hCA1 + sulfonamide derivative<br /> |
| + | **[[6i0j]] – hCA1 + sulfamate derivative<br /> | ||
**[[3b1b]] – CrCA1 – ''Chlamydomonas rheinhardtii''<br /> | **[[3b1b]] – CrCA1 – ''Chlamydomonas rheinhardtii''<br /> | ||
**[[4xiw]] – CrCA1 + acetazolamide <br /> | **[[4xiw]] – CrCA1 + acetazolamide <br /> | ||
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*''Carbonic anhydrase II'' | *''Carbonic anhydrase II'' | ||
| + | **[[3mwo]], [[3ks3]], [[3gz0]], [[3efi]], [[2ili]], [[2ax2]], [[1xev]], [[1t9n]], [[1tb0]], [[1tbt]], [[1te3]], [[1teq]], [[1teu]], [[1tg3]], [[1tg9]], [[1th9]], [[1thk]], [[1lug]], [[1luq]], [[1cng]], [[1cnh]], [[1cni]], [[1cnj]], [[1cnk]], [[1yda]], [[1ydb]], [[1ydc]], [[1ydd]], [[1ccs]], [[1cct]], [[1ccu]], [[1cvh]], [[1cvd]], [[1cve]], [[1cvf]], [[1cnb]], [[1cnc]], [[4cac]], [[5cac]], [[1cva]], [[1cvb]], [[1mua]], [[2cba]], [[2cbb]], [[2cbe]], [[1dca]], [[1dcb]], [[4ca2]], [[5ca2]], [[12ca]], [[1ca3]], [[1hca]], [[1hea]], [[1heb]], [[1hec]], [[1hed]], [[6ca2]], [[7ca2]], [[8ca2]], [[9ca2]], [[1ca2]], [[2fmg]], [[3tmj]], [[3v2j]], [[3v2m]], [[3zp9]], [[4q49]], [[4zao]], [[5yui]], [[5yuj]], [[5dsk]], [[5dsl]], [[5dsm]], [[5yuk]], [[5dso]], [[5dsp]], [[5dsq]], [[5dsr]], [[5y2r]], [[5y2s]], [[6fji]], [[5zxw]], [[6km3]], [[6km4]], [[6km5]], [[6km6]], [[6luu]], [[6luv]], [[6luw]], [[6lux]], [[6luy]], [[6luz]], [[6lv1]], [[6lv2]], [[6lv3]], [[6lv4]], [[6lv5]], [[6lv9]], [[6pea]] – hCA2<br /> | ||
| + | **[[6hd2]] – hCA2 – NMR<br /> | ||
| + | **[[3kkx]], [[4y0j]] – hCA2 - Neutron<br /> | ||
| + | **[[3koi]], [[3kok]], [[3kon]], [[1rza]], [[1rzb]] – hCA2 + Co <br /> | ||
| + | **[[1fqr]], [[1fsq]] – hCA2 (mutant) + Co <br /> | ||
| + | **[[1rzc]], [[5eoi]], [[6pdv]] – hCA2 + Cu <br /> | ||
| + | **[[1fr4]], [[1fsr]] – hCA2 (mutant) + Cu<br /> | ||
| + | **[[1rzd]] – hCA2 + Mn <br /> | ||
| + | **[[1rze]], [[6h6s]], [[6lv6]], [[6lv7]], [[6lv8]] – hCA2 + Ni <br /> | ||
| + | **[[1yo0]], [[1yo1]], [[1yo2]], [[1lzv]], [[1moo]], [[1fql]], [[1fqm]], [[1fqn]], [[1fr7]], [[1fsn]], [[1g3z]], [[1g0f]], [[1h9n]], [[1h9q]], [[1ugc]], [[1uge]], [[1ugf]], [[1uga]], [[1ugb]], [[1ugd]], [[1ugg]], [[1zsa]], [[1zsc]], [[1cvc]], [[1cai]], [[1caj]], [[1cak]], [[1cal]], [[1cam]], [[1hva]], [[2fnn]], [[2wd2]], [[3m1q]], [[3m1w]], [[3m5s]], [[3m5t]], [[3m2z]], [[3mnh]], [[3mni]], [[3mnj]], [[3mnk]], [[3dv7]], [[3dvb]], [[3dvc]], [[3dvd]], [[2nwo]], [[2nwp]], [[2nwy]], [[2nwz]], [[2nxr]], [[2nxs]], [[2nxt]], [[2fnk]], [[2fnm]], [[3rg3]], [[3rg4]], [[3rge]], [[3rld]], [[3tvn]], [[3tvo]], [[3u3a]], [[3u45]], [[3u47]], [[3v3f]], [[3v3g]], [[3v3h]], [[3v3i]], [[3v3j]], [[4idr]], [[3u7c]], [[4hba]], [[4js6]], [[4jsw]], [[4gl1]], [[4k1q]], [[4l5u]], [[4l5v]], [[4l5w]], [[4qk1]], [[4qk2]], [[4qk3]], [[4pxx]], [[5bru]], [[5brv]], [[5brw]], [[6b00]], [[6klz]], [[6km0]], [[6km1]], [[6km2]] - hCA2 (mutant) <br /> | ||
**[[1v9e]], [[5a25]], [[5ezt]] – bCA2 – bovine<br /> | **[[1v9e]], [[5a25]], [[5ezt]] – bCA2 – bovine<br /> | ||
**[[1v9i]], [[4cnr]], [[4cnv]], [[4cnw]], [[4cnx]] – bCA2 (mutant) <br /> | **[[1v9i]], [[4cnr]], [[4cnv]], [[4cnw]], [[4cnx]] – bCA2 (mutant) <br /> | ||
| - | **[[ | + | **[[1y7w]] – CA2 – ''Dunaliella salina''<br /> |
| - | + | **[[2w3n]], [[2w3q]] – CA2 – ''Cryptococcus neoformans''<br /> | |
| - | **[[ | + | |
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*''Carbonic anhydrase II binary complex'' | *''Carbonic anhydrase II binary complex'' | ||
**[[1xeg]], [[1cay]], [[1caz]] – hCA2 + acetate<br /> | **[[1xeg]], [[1cay]], [[1caz]] – hCA2 + acetate<br /> | ||
| - | **[[3ml2]], [[3mmf]], [[3mna]], [[3nb5]], [[3p4v]], [[3po6]], [[3n0n]], [[3mzc]], [[3n2p]], [[3n3j]], [[3n4b]], [[3m98]], [[3m2n]], [[3m96]], [[3myq]], [[3l14]], [[3kig]], [[3m1k]], [[3m67]], [[3m3x]], [[3m40]], [[3m5e]], [[3mhi]], [[3mhl]], [[3mhm]], [[3mho]], [[3mhc]], [[3kwa]], [[3mnu]], [[3k34]], [[2x7s]], [[2x7t]], [[2x7u]], [[3igp]], [[3hlj]], [[2wd3]], [[3ieo]], [[3hs4]], [[3k2f]], [[2weg]], [[2weh]], [[2wej]], [[2weo]], [[3hkn]], [[3hkq]], [[3hkt]], [[3hku]], [[3f8e]], [[3ibi]], [[3ibl]], [[3ibn]], [[3ibu]], [[3eft]], [[3ffp]], [[3f4x]], [[3d8w]], [[3d9z]], [[3daz]], [[3dbu]], [[3dc3]], [[3dc9]], [[3dcc]], [[3dcs]], [[3dcw]], [[3dd0]], [[3c7p]], [[3bet]], [[3bl1]], [[2osf]], [[3cyu]], [[3caj]], [[2osm]], [[2qo8]], [[2qoa]], [[3b4f]], [[3bl0]], [[2pou]], [[2pov]], [[2pow]], [[2hl4]], [[2o4z]], [[2nng]], [[2nno]], [[2nns]], [[2nnv]], [[2h15]], [[2gd8]], [[2hnc]], [[2f14]], [[2hoc]], [[2hd6]], [[2eu2]], [[2eu3]], [[2aw1]], [[2geh]], [[1z9y]], [[1zfk]], [[1zfq]], [[1zge]], [[1zgf]], [[1zh9]], [[1ze8]], [[1xpz]], [[1xq0]], [[1ttm]], [[1oq5]], [[1kwq]], [[1kwr]], [[1if4]], [[1if5]], [[1if6]], [[1if7]], [[1if8]], [[1if9]], [[1i8z]], [[1i90]], [[1i91]], [[1g1d]], [[1g52]], [[1g53]], [[1g54]], [[1am6]], [[1h4n]], [[2h4n]], [[1okl]], [[1okm]], [[1okn]], [[1cnw]], [[1cnx]], [[1cny]], [[1cil]], [[1cim]], [[1cin]], [[1cra]], [[1bcd]], [[2ca2]], [[3ca2]], [[3m04]], [[3m14]], [[3m2x]], [[3m2y]], [[3r16]], [[3r17]], [[3ni5]], [[3nj9]], [[3oim]], [[3oku]], [[3oy0]], [[3oyq]], [[3oys]], [[3p3h]], [[3p3j]], [[3p44]], [[3p55]], [[3p58]], [[3p5a]], [[3p5l]], [[3ryj]], [[3ryv]], [[3ryx]], [[3ryy]], [[3ryz]], [[3rz0]], [[3rz1]], [[3rz5]], [[3rz7]], [[3rz8]], [[3t82]], [[3t83]], [[3t84]], [[3t85]], [[3qyk]], [[3rj7]], [[3s73]], [[3s8x]], [[3s9t]], [[3sap]], [[3sax]], [[3sbh]], [[3sbi]], [[3v7x]], [[3vbd]], [[3t5u]], [[3t5z]], [[3v5g]], [[4e3d]], [[4e3f]], [[4e3g]], [[4e3h]], [[4e49]], [[4e4a]], [[4fl7]], [[4bf1]], [[4bf6]], [[4mty]], [[4mlt]], [[4mlx]], [[4cq0]], [[4q78]], [[4q7p]], [[4q7s]], [[4q7v]], [[4q7w]], [[4q81]], [[4q83]], [[4q87]], [[4q8x]], [[4q8y]], [[4q8z]], [[4q90]], [[4q99]], [[4q9y]], [[4rfc]], [[4rfd]], [[4rh2]], [[4wl4]], [[4zwi]], [[4zwy]], [[4zx0]], [[5amd]], [[5amg]], [[5aml]], [[5bnl]], [[5byi]], [[5c8i]], [[6b4d]], [[5eh7]], [[5eh8]], [[5ehv]], [[5ehw]], [[5flo]], [[5flp]], [[5flq]], [[5fls]], [[5flt]], [[5fng]], [[5fnh]], [[5fni]], [[5fnj]], [[5fnk]], [[5fnl]], [[5fnm]], [[5jq0]], [[5jqt]], [[5l3o]], [[5l6k]], [[5lmd]], [[5lvs]], [[5thj]], [[5thn]], [[5umc]], [[5wg7]], [[5wgp]], [[6c7x]] - hCA2 + inhibitor<br /> | + | **[[3ml2]], [[3mmf]], [[3mna]], [[3nb5]], [[3p4v]], [[3po6]], [[3n0n]], [[3mzc]], [[3n2p]], [[3n3j]], [[3n4b]], [[3m98]], [[3m2n]], [[3m96]], [[3myq]], [[3l14]], [[3kig]], [[3m1k]], [[3m67]], [[3m3x]], [[3m40]], [[3m5e]], [[3mhi]], [[3mhl]], [[3mhm]], [[3mho]], [[3mhc]], [[3kwa]], [[3mnu]], [[3k34]], [[2x7s]], [[2x7t]], [[2x7u]], [[3igp]], [[3hlj]], [[2wd3]], [[3ieo]], [[3hs4]], [[3k2f]], [[2weg]], [[2weh]], [[2wej]], [[2weo]], [[3hkn]], [[3hkq]], [[3hkt]], [[3hku]], [[3f8e]], [[3ibi]], [[3ibl]], [[3ibn]], [[3ibu]], [[3eft]], [[3ffp]], [[3f4x]], [[3d8w]], [[3d9z]], [[3daz]], [[3dbu]], [[3dc3]], [[3dc9]], [[3dcc]], [[3dcs]], [[3dcw]], [[3dd0]], [[3c7p]], [[3bet]], [[3bl1]], [[2osf]], [[3cyu]], [[3caj]], [[2osm]], [[2qo8]], [[2qoa]], [[3b4f]], [[3bl0]], [[2pou]], [[2pov]], [[2pow]], [[2hl4]], [[2o4z]], [[2nng]], [[2nno]], [[2nns]], [[2nnv]], [[2h15]], [[2gd8]], [[2hnc]], [[2f14]], [[2hoc]], [[2hd6]], [[2eu2]], [[2eu3]], [[2aw1]], [[2geh]], [[1z9y]], [[1zfk]], [[1zfq]], [[1zge]], [[1zgf]], [[1zh9]], [[1ze8]], [[1xpz]], [[1xq0]], [[1ttm]], [[1oq5]], [[1kwq]], [[1kwr]], [[1if4]], [[1if5]], [[1if6]], [[1if7]], [[1if8]], [[1if9]], [[1i8z]], [[1i90]], [[1i91]], [[1g1d]], [[1g52]], [[1g53]], [[1g54]], [[1am6]], [[1h4n]], [[2h4n]], [[1okl]], [[1okm]], [[1okn]], [[1cnw]], [[1cnx]], [[1cny]], [[1cil]], [[1cim]], [[1cin]], [[1cra]], [[1bcd]], [[2ca2]], [[3ca2]], [[3m04]], [[3m14]], [[3m2x]], [[3m2y]], [[3r16]], [[3r17]], [[3ni5]], [[3nj9]], [[3oim]], [[3oku]], [[3oy0]], [[3oyq]], [[3oys]], [[3p3h]], [[3p3j]], [[3p44]], [[3p55]], [[3p58]], [[3p5a]], [[3p5l]], [[3ryj]], [[3ryv]], [[3ryx]], [[3ryy]], [[3ryz]], [[3rz0]], [[3rz1]], [[3rz5]], [[3rz7]], [[3rz8]], [[3t82]], [[3t83]], [[3t84]], [[3t85]], [[3qyk]], [[3rj7]], [[3s73]], [[3s8x]], [[3s9t]], [[3sap]], [[3sax]], [[3sbh]], [[3sbi]], [[3v7x]], [[3vbd]], [[3t5u]], [[3t5z]], [[3v5g]], [[4e3d]], [[4e3f]], [[4e3g]], [[4e3h]], [[4e49]], [[4e4a]], [[4fl7]], [[4bf1]], [[4bf6]], [[4mty]], [[4mlt]], [[4mlx]], [[4cq0]], [[4q78]], [[4q7p]], [[4q7s]], [[4q7v]], [[4q7w]], [[4q81]], [[4q83]], [[4q87]], [[4q8x]], [[4q8y]], [[4q8z]], [[4q90]], [[4q99]], [[4q9y]], [[4rfc]], [[4rfd]], [[4rh2]], [[4wl4]], [[4zwi]], [[4zwy]], [[4zx0]], [[5amd]], [[5amg]], [[5aml]], [[5bnl]], [[5byi]], [[5c8i]], [[6b4d]], [[5eh7]], [[5eh8]], [[5ehv]], [[5ehw]], [[5flo]], [[5flp]], [[5flq]], [[5fls]], [[5flt]], [[5fng]], [[5fnh]], [[5fni]], [[5fnj]], [[5fnk]], [[5fnl]], [[5fnm]], [[5jq0]], [[5jqt]], [[5l3o]], [[5l6k]], [[5lmd]], [[5lvs]], [[5thj]], [[5thn]], [[5umc]], [[5wg7]], [[5wgp]], [[6b4d]], [[6c7x]], [[6sdh]], [[6sdi]], [[6sdj]], [[6sfq]], [[6sg0]], [[6uzu]], [[6xwz]], [[6yma]], [[6yqu]], [[7bi5]], [[7jo0]], [[7jo1]], [[7jo2]], [[7jo3]], [[7job]], [[7ntb]], [[7onp]], [[7qbh]] - hCA2 + inhibitor<br /> |
| - | **[[4fpt]], [[4frc]], [[4dz9]], [[4dz7]], [[4fu5]], [[4fvn]], [[4fvo]], [[4ht0]], [[4ht2]], [[4ilx]], [[4jsa]], [[4jss]], [[4jsz]], [[4kap]], [[3s71]], [[3s72]], [[3s74]], [[3s75]], [[3s76]], [[3s77]], [[3s78]], [[1bnq]], [[1bnt]], [[1bnu]], [[1bnw]], [[1bn1]], [[1bn3]], [[1bn4]], [[1bnm]], [[1bnn]], [[1a42]], [[1bnv]], [[4itp]], [[4kni]], [[4knj]], [[4mdg]], [[4mdl]], [[4mdm]], [[4mo8]], [[4n0x]], [[4ito]], [[4kuv]], [[4kuw]], [[4kuy]], [[4kv0]], [[4lhi]], [[4pq7]], [[4pyx]], [[4pyy]], [[4pzh]], [[4q6d]], [[4q6e]], [[4qsa]], [[4qsb]], [[4qsi]], [[4cq0]], [[4qiy]], [[4qjm]], [[4qtl]], [[4rux]], [[4ruy]], [[4ruz]], [[4ww6]], [[4yvy]], [[4yx4]], [[4yxi]], [[4yxo]], [[4yxu]], [[4yyt]], [[4z0q]], [[4z1e]], [[4z1j]], [[4z1k]], [[4z1n]], [[5a6h]], [[5dog]], [[5doh]], [[5drs]], [[5e28]], [[5e2k]], [[5e2r]], [[5e2s]], [[5eh5]], [[5ehe]], [[5eij]], [[5fdc]], [[5fdi]], [[5flr]], [[5g01]], [[5g03]], [[5j8z]], [[5sz0]], [[5sz1]], [[5sz2]], [[5sz3]], [[5sz4]], [[5sz5]], [[5sz6]], [[5sz7]], [[5jmz]], [[ | + | **[[3kne]], [[1lg5]], [[1lg6]], [[1i9l]], [[1i9m]], [[1i9n]], [[1i9o]], [[1i9p]], [[1i9q]], [[1g45]], [[1g46]], [[1g48]], [[1g4j]], [[1g4o]], [[1g0e]], [[3oik]], [[3oil]], [[3okv]], [[3pyk]], [[3pjj]], [[4fik]], [[4bcw]], [[4zwx]], [[4zwz]], [[4zx1]], [[5ekh]], [[5ekj]], [[5ekm]], [[5g0b]], [[5g0c]], [[5jdv]], [[5je7]], [[5jeg]], [[5jeh]], [[5jep]], [[5jes]], [[5jg3]], [[5jg5]], [[5jgs]], [[5jgt]], [[5thi]], [[5ti0]], [[6nj2]], [[6nj3]], [[6nj4]], [[6nj5]], [[6nj6]], [[7mu3]], [[7onm]], [[7onq]], [[7onv]] - hCA2 (mutant) + inhibitor<br /> |
| - | **[[4q06]], [[4q07]], [[4q08]], [[4q09]], [[5t71]], [[5t72]], [[5t75]], [[6eea]], [[6eeh]], [[6eeo]], [[5ogo]] - hCA2 (mutant) + sulfonamide inhibitor<br /> | + | **[[4fpt]], [[4frc]], [[4dz9]], [[4dz7]], [[4fu5]], [[4fvn]], [[4fvo]], [[4ht0]], [[4ht2]], [[4ilx]], [[4jsa]], [[4jss]], [[4jsz]], [[4kap]], [[3s71]], [[3s72]], [[3s74]], [[3s75]], [[3s76]], [[3s77]], [[3s78]], [[1bnq]], [[1bnt]], [[1bnu]], [[1bnw]], [[1bn1]], [[1bn3]], [[1bn4]], [[1bnm]], [[1bnn]], [[1a42]], [[1bnv]], [[4itp]], [[4kni]], [[4knj]], [[4mdg]], [[4mdl]], [[4mdm]], [[4mo8]], [[4n0x]], [[4ito]], [[4kuv]], [[4kuw]], [[4kuy]], [[4kv0]], [[4lhi]], [[4pq7]], [[4pyx]], [[4pyy]], [[4pzh]], [[4q6d]], [[4q6e]], [[4qsa]], [[4qsb]], [[4qsi]], [[4cq0]], [[4qiy]], [[4qjm]], [[4qtl]], [[4rux]], [[4ruy]], [[4ruz]], [[4ww6]], [[4yvy]], [[4yx4]], [[4yxi]], [[4yxo]], [[4yxu]], [[4yyt]], [[4z0q]], [[4z1e]], [[4z1j]], [[4z1k]], [[4z1n]], [[5a6h]], [[5dog]], [[5doh]], [[5drs]], [[5e28]], [[5e2k]], [[5e2r]], [[5e2s]], [[5eh5]], [[5ehe]], [[5eij]], [[5fdc]], [[5fdi]], [[5flr]], [[5g01]], [[5g03]], [[5j8z]], [[5sz0]], [[5sz1]], [[5sz2]], [[5sz3]], [[5sz4]], [[5sz5]], [[5sz6]], [[5sz7]], [[5jmz]], [[6uzu]], [[5jn3]], [[5jn7]], [[5ljq]], [[5ljt]], [[5ll4]], [[5ll8]], [[5llc]], [[5lle]], [[5llg]], [[5llh]], [[5mjn]], [[5n0d]], [[5n0e]], [[5n1r]], [[5n1s]], [[5n24]], [[5n25]], [[5nea]], [[5nee]], [[5nxi]], [[5nxm]], [[5nxo]], [[5nya]], [[5uln]], [[5wex]], [[6equ]], [[6qfu]], [[6qfv]], [[6qfw]], [[6qfx]], [[6h33]], [[6h34]], [[6h2z]], [[6got]], [[6g6t]], [[6ecz]], [[6eda]], [[6ebe]], [[6d1m]], [[6d1l]], [[6ceh]], [[6b5a]], [[6b59]], [[5wlv]], [[5wlu]], [[5wlt]], [[5wlr]], [[6gdc]], [[6gm9]], [[6gxb]], [[6gxe]], [[6h3q]], [[6hqx]], [[6hr3]], [[6hxd]], [[6i0w]], [[6i1u]], [[6i2f]], [[6i3e]], [[6oto]], [[6otp]], [[6otq]], [[6oub]], [[6oue]], [[6ouh]], [[6ouj]], [[6ouk]], [[6r6f]], [[6r6j]], [[6rfh]], [[6rg3]], [[6rg4]], [[6rg5]], [[6rh4]], [[6rhj]], [[6rhk]], [[6rig]], [[6rit]], [[6rjj]], [[6rkn]], [[6rl9]], [[6rnp]], [[6rob]], [[6roe]], [[6rqi]], [[6rrg]], [[6rri]], [[6rs5]], [[6rsz]], [[6rzx]], [[6s03]], [[6s9g]], [[6sbh]], [[6sbl]], [[6sbm]], [[6sd7]], [[6sds]], [[6sdl]], [[6sey]], [[6sfu]], [[6sg6]], [[6sks]], [[6skt]], [[6skv]], [[6sx9]], [[6syb]], [[6sys]], [[6t4n]], [[6t4o]], [[6t4p]], [[6t5c]], [[6t81]], [[6ufb]], [[6ufc]], [[6ufd]], [[6vkg]], [[6wq4]], [[6wq5]], [[6wq7]], [[6wq8]], [[6wq9]], [[[6xvh]], [6xxt]], [[6yh4]], [[6yh5]], [[6yh6]], [[6yh7]], [[6yh8]], [[6yha]], [[6yhb]], [[6yhc]], [[6yj3]], [[6ykc]], [[6ykh]], [[6yo2]], [[6yo4]], [[6yo7]], [[6yoi]], [[6yok]], [[6yol]], [[6ypw]], [[6yqt]], [[6yzj]], [[6yzl]], [[6yzk]], [[6yzm]], [[6yzn]], [[6yzo]], [[6yzp]], [[6yzq]], [[6yzr]], [[6yzs]], [[6yzt]], [[6yzu]], [[6yzv]], [[6yzw]], [[6yzx]], [[6z04]], [[7a6v]], [[7aeq]], [[7aes]], [[7agn]], [[7asj]], [[7bfa]], [[7bg5]], [[7bhh]], [[7jnr]], [[7jnv]], [[7jnw]], [[7jnx]], [[7jnz]], [[7joc]], [[7k6i]], [[7k6j]], [[7k6k]], [[7k6l]], [[7k6t]], [[7k6u]], [[7k6x]], [[7k6z]], [[7nh6]], [[7nh8]], [[7nzr]], [[7nzs]], [[7nzt]], [[7nzu]], [[7nzw]], [[7nzx]], [[7ok8]], [[7orp]], [[7orq]], [[7q0c]], [[7q0e]], [[7qgx]], [[7qgy]], [[7qgz]], [[7rny]], [[7rnz]], [[7suw]], [[7suy]], [[7sv1]], [[7sv8]] - hCA2 + sulfonamide inhibitor<br /> |
| + | **[[4q06]], [[4q07]], [[4q08]], [[4q09]], [[5t71]], [[5t72]], [[5t75]], [[6eea]], [[6eeh]], [[6eeo]], [[5ogo]], [[6oti]], [[6otk]], [[6otm]], [[6oud]], [[6ouf]], [[6oui]], [[6oum]], [[6ql1]], [[6ql3]], [[6rmx]], [[6rmy]], [[6rof]], [[6sdt]] - hCA2 (mutant) + sulfonamide inhibitor<br /> | ||
**[[6qeb]] - hCA2 + sulfonamide inhibitor - NMR<br /> | **[[6qeb]] - hCA2 + sulfonamide inhibitor - NMR<br /> | ||
**[[2fos]], [[2fou]], [[2fov]], [[2foy]], [[2foq]] - hCA2 + two-prong inhibitor<br /> | **[[2fos]], [[2fou]], [[2fov]], [[2foy]], [[2foq]] - hCA2 + two-prong inhibitor<br /> | ||
| - | **[[3kne]], [[1lg5]], [[1lg6]], [[1i9l]], [[1i9m]], [[1i9n]], [[1i9o]], [[1i9p]], [[1i9q]], [[1g45]], [[1g46]], [[1g48]], [[1g4j]], [[1g4o]], [[1g0e]], [[3oik]], [[3oil]], [[3okv]], [[3pyk]], [[3pjj]], [[4fik]], [[4bcw]], [[4zwx]], [[4zwz]], [[4zx1]], [[5ekh]], [[5ekj]], [[5ekm]], [[5g0b]], [[5g0c]], [[5jdv]], [[5je7]], [[5jeg]], [[5jeh]], [[5jep]], [[5jes]], [[5jg3]], [[5jg5]], [[5jgs]], [[5jgt]], [[5thi]], [[5ti0]] - hCA2 (mutant) + inhibitor<br /> | ||
**[[1cah]] - hCA2 (Co) + bicarbonate<br /> | **[[1cah]] - hCA2 (Co) + bicarbonate<br /> | ||
**[[1lgd]], [[1bic]] - hCA2 (mutant) + bicarbonate<br /> | **[[1lgd]], [[1bic]] - hCA2 (mutant) + bicarbonate<br /> | ||
| - | **[[3m1j]] – hCA2 + anticancer | + | **[[3m1j]], [[6ic2]], [[3dd8]], [[2qp6]], [[6nm0]], [[6pgx]], [[6t7u]], [[6t9z]], [[6u4q]], [[6u4t]], [[6ugn]], [[6ugo]], [[6ugp]], [[6ugr]], [[6uh0]] – hCA2 + anticancer inhibitor<br /> |
| - | **[[ | + | **[[6nlv]] – hCA2 (mutant) + anticancer inhibitor<br /> |
| + | **[[6odz]], [[6oe0]], [[6oe1]] – hCA2 + anti-pain drug <br /> | ||
**[[1eou]] - hCA2 + anticonvulsant sulfamate<br /> | **[[1eou]] - hCA2 + anticonvulsant sulfamate<br /> | ||
**[[4r5b]] – hCA2 + sulfamate inhibitor<br /> | **[[4r5b]] – hCA2 + sulfamate inhibitor<br /> | ||
**[[4r59]], [[4r5a]], [[6c7n]], [[6c7w]] – hCA2 (mutant) + sulfamate inhibitor<br /> | **[[4r59]], [[4r5a]], [[6c7n]], [[6c7w]] – hCA2 (mutant) + sulfamate inhibitor<br /> | ||
**[[6c7x]] – hCA2 + sulfamoyladenosine inhibitor<br /> | **[[6c7x]] – hCA2 + sulfamoyladenosine inhibitor<br /> | ||
| + | **[[6rvf]], [[6rvk]], [[6rvl]], [[6rw1]] – hCA2 + benzoxaborole inhibitor<br /> | ||
**[[2q1q]], [[4g0c]] – hCA2 + antiepileptic drug<br /> | **[[2q1q]], [[4g0c]] – hCA2 + antiepileptic drug<br /> | ||
| - | **[[5gmn]] – hCA2 + NSAID drug<br /> | + | **[[5gmn]], [[7m23]], [[7m24]], [[7m26]], [[7pri]], [[8dj9]] – hCA2 + NSAID drug<br /> |
**[[6e92]], [[6e91]], [[6e8x]], [[6e8p]] – hCA2 (mutant) + NSAID drug<br /> | **[[6e92]], [[6e91]], [[6e8x]], [[6e8p]] – hCA2 (mutant) + NSAID drug<br /> | ||
**[[6bc9]], [[6bbs]], [[6bcc]] – hCA2 + glaucoma drug<br /> derivative | **[[6bc9]], [[6bbs]], [[6bcc]] – hCA2 + glaucoma drug<br /> derivative | ||
| Line 82: | Line 88: | ||
**[[5tfx]], [[5txy]], [[5ty1]], [[5ty8]], [[5ty9]], [[5tya]], [[5u0d]], [[5u0e]], [[5u0f]], [[5u0g]] – hCA2 + oxazole derivative<br /> | **[[5tfx]], [[5txy]], [[5ty1]], [[5ty8]], [[5ty9]], [[5tya]], [[5u0d]], [[5u0e]], [[5u0f]], [[5u0g]] – hCA2 + oxazole derivative<br /> | ||
**[[4iwz]], [[4m2r]], [[4m2u]], [[4rn4]] – hCA2 + azolamide derivative<br /> | **[[4iwz]], [[4m2r]], [[4m2u]], [[4rn4]] – hCA2 + azolamide derivative<br /> | ||
| - | **[[4m2w]], [[4m2v]], [[4k0s]], [[4k0t]], [[4k0z]], [[4k13]] – hCA2 (mutant) + azolamide derivative<br /> | + | **[[4m2w]], [[4m2v]], [[4k0s]], [[4k0t]], [[4k0z]], [[4k13]], [[6ql2]] – hCA2 (mutant) + azolamide derivative<br /> |
| - | **[[4lp6]], [[5l6t]], [[5l70]], [[5l9e]] – hCA2 + quinoline derivative<br /> | + | **[[4lp6]], [[5l6t]], [[5l70]], [[5l9e]], [[6q3o]] – hCA2 + quinoline derivative<br /> |
| + | **[[6hzx]], [[6q9t]] – hCA2 + quinoline derivative + sulfamide derivative + pyridine derivative<br /> | ||
**[[3k7k]], [[1can]], [[1cao]], [[1ray]], [[1raz]], [[2cbc]], [[2cbd]], [[4ygj]], [[4ygk]], [[4ygl]], [[4ygn]] – hCA2 + anion<br /> | **[[3k7k]], [[1can]], [[1cao]], [[1ray]], [[1raz]], [[2cbc]], [[2cbd]], [[4ygj]], [[4ygk]], [[4ygl]], [[4ygn]] – hCA2 + anion<br /> | ||
**[[4n16]] – hCA2 + cholate<br /> | **[[4n16]] – hCA2 + cholate<br /> | ||
| + | **[[7rre]], [[7rrf]] – hCA2 + galactose<br /> | ||
| + | **[[6ux1]] – hCA2 + salicilate<br /> | ||
**[[6mbv]] – hCA2 + nicotinic acid<br /> | **[[6mbv]] – hCA2 + nicotinic acid<br /> | ||
| + | **[[6yri]] – hCA2 + caffeic acid<br /> | ||
**[[6mby]] – hCA2 + ferulic acid<br /> | **[[6mby]] – hCA2 + ferulic acid<br /> | ||
| - | **[[4qy3]], [[5m78]] – hCA2 + benzoate<br /> | + | **[[4qy3]], [[5m78]], [[6rm1]], [[6rmp]], [[6s9z]], [[6sac]], [[6sas]], [[6say]], [[6sb7]] – hCA2 + benzoate derivative<br /> |
**[[6hx5]], [[6h29]] – hCA2 + benzene derivative<br /> | **[[6hx5]], [[6h29]] – hCA2 + benzene derivative<br /> | ||
**[[6g3q]] – hCA2 + famotidine<br /> | **[[6g3q]] – hCA2 + famotidine<br /> | ||
| Line 96: | Line 106: | ||
**[[5nxp]], [[5nxv]], [[5nxw]] – hCA2 + ethanamide inhibitor<br /> | **[[5nxp]], [[5nxv]], [[5nxw]] – hCA2 + ethanamide inhibitor<br /> | ||
**[[5t74]] – hCA2 (mutant) + ethanamide inhibitor<br /> | **[[5t74]] – hCA2 (mutant) + ethanamide inhibitor<br /> | ||
| + | **[[6vj3]] – hCA2 + pyrimidine inhibitor<br /> | ||
**[[5th4]], [[5w8b]] – hCA2 (mutant) + pyridine inhibitor<br /> | **[[5th4]], [[5w8b]] – hCA2 (mutant) + pyridine inhibitor<br /> | ||
**[[2q38]], [[2q1b]], [[5clu]], [[4xe1]], [[6gcy]], [[6fjj]] – hCA2 + saccharin derivative<br /> | **[[2q38]], [[2q1b]], [[5clu]], [[4xe1]], [[6gcy]], [[6fjj]] – hCA2 + saccharin derivative<br /> | ||
| Line 101: | Line 112: | ||
**[[6cjv]] – hCA2 + sucralose<br /> | **[[6cjv]] – hCA2 + sucralose<br /> | ||
**[[1g6v]] – bCA2 + antibody heavy chain<br /> | **[[1g6v]] – bCA2 + antibody heavy chain<br /> | ||
| - | **[[1y7w]] – CA2 – ''Dunaliella salina''<br /> | ||
| - | **[[2w3n]], [[2w3q]] – CA2 – ''Cryptococcus neoformans''<br /> | ||
*''Carbonic anhydrase III'' | *''Carbonic anhydrase III'' | ||
| Line 113: | Line 122: | ||
**[[1znc]] – hCA4<br /> | **[[1znc]] – hCA4<br /> | ||
| - | **[[2znc]] – mCA4 – mouse<br /> | ||
| - | **[[3znc]] – mCA4 + inhibitor<br /> | ||
**[[5ipz]], [[3fw3]], [[3f7b]], [[3f7u]], [[5jnc]] – hCA4 soluble domain + sulfonamide inhibitor<br /> | **[[5ipz]], [[3fw3]], [[3f7b]], [[3f7u]], [[5jnc]] – hCA4 soluble domain + sulfonamide inhibitor<br /> | ||
**[[5jn8]], [[5jn9]], [[5ku6]] – hCA4 soluble domain + azolamide inhibitor<br /> | **[[5jn8]], [[5jn9]], [[5ku6]] – hCA4 soluble domain + azolamide inhibitor<br /> | ||
**[[5jna]] – hCA4 soluble domain + antiepilepsy drug<br /> | **[[5jna]] – hCA4 soluble domain + antiepilepsy drug<br /> | ||
| + | **[[2znc]] – mCA4 – mouse<br /> | ||
| + | **[[3znc]] – mCA4 + inhibitor<br /> | ||
*''Carbonic anhydrase V'' | *''Carbonic anhydrase V'' | ||
| Line 133: | Line 142: | ||
**[[3mdz]] – hCA7<br /> | **[[3mdz]] – hCA7<br /> | ||
**[[3ml5]], [[6g4t]] – hCA7 (mutant)<br /> | **[[3ml5]], [[6g4t]] – hCA7 (mutant)<br /> | ||
| + | **[[6sdt]], [[7nc4]], [[7p1a]] – hCA7 + sulfonamide derivative<br /> | ||
**[[6h36]], [[6h37]], [[6h38]] – hCA7 (mutant) + sulfonamide derivative<br /> | **[[6h36]], [[6h37]], [[6h38]] – hCA7 (mutant) + sulfonamide derivative<br /> | ||
| Line 142: | Line 152: | ||
*''Carbonic anhydrase IX'' | *''Carbonic anhydrase IX'' | ||
| + | **[[6rqu]] – hCA9 <br /> | ||
| + | **[[6rqn]], [[6rqq]], [[6rqw]] – hCA9 (mutant) <br /> | ||
| + | **[[6y74]] – hCA9 catalytic domain<br /> | ||
**[[3iai]], [[5dvx]], [[6fe2]] – hCA9 catalytic domain (mutant)<br /> | **[[3iai]], [[5dvx]], [[6fe2]] – hCA9 catalytic domain (mutant)<br /> | ||
**[[2hkf]] – hCA9 peptide + antibody<br /> | **[[2hkf]] – hCA9 peptide + antibody<br /> | ||
**[[4ywp]] – hCA9 (mutant) + sucrose <br /> | **[[4ywp]] – hCA9 (mutant) + sucrose <br /> | ||
| - | **[[5fl4]], [[6fe0]] – hCA9 + sulfonamide inhibitor<br /> | + | **[[5fl4]], [[6fe0]], [[6qn2]], [[6qn5]], [[6qn6]], [[6qut]], [[6tl5]], [[6tl6]], [[7pom]] – hCA9 + sulfonamide inhibitor<br /> |
**[[5fl5]], [[5fl6]], [[6g98]], [[6g9u]], [[6fe1]] – hCA9 (mutant) + sulfonamide inhibitor<br /> | **[[5fl5]], [[5fl6]], [[6g98]], [[6g9u]], [[6fe1]] – hCA9 (mutant) + sulfonamide inhibitor<br /> | ||
| + | **[[6ugo]], [[6ugq]], [[6ugz]] – hCA9 + anticancer inhibitor<br /> | ||
*''Carbonic anhydrase XII'' | *''Carbonic anhydrase XII'' | ||
| Line 152: | Line 166: | ||
**[[1jcz]] - hCA12 extracellular domain<br /> | **[[1jcz]] - hCA12 extracellular domain<br /> | ||
**[[1jd0]] - hCA12 extracellular domain + inhibitor<br /> | **[[1jd0]] - hCA12 extracellular domain + inhibitor<br /> | ||
| - | **[[4kp5]], [[4kp8]], [[4q0l]], [[4qj0]], [[4qjo]], [[4qjw]], [[4ww8]], [[5ll5]], [[5ll9]], [[5llo]], [[5llp]], [[5msa]], [[5msb]], [[6g7a]], [[6g5l]] – hCA12 + sulfonamide inhibitor<br /> | + | **[[4kp5]], [[4kp8]], [[4q0l]], [[4qj0]], [[4qjo]], [[4qjw]], [[4ww8]], [[5ll5]], [[5ll9]], [[5llo]], [[5llp]], [[5msa]], [[5msb]], [[6g7a]], [[6g5l]], [[6qn0]], [[6qng]], [[6qnl]], [[6r6y]], [[6r71]], [[6t5p]], [[6t5q]], [[7pp9]], [[7puu]], [[7puv]], [[7puw]] – hCA12 + sulfonamide inhibitor<br /> |
| + | ** [[6rps]] – hCA12 + antibody<br /> | ||
*''Carbonic anhydrase XIII'' | *''Carbonic anhydrase XIII'' | ||
| Line 160: | Line 175: | ||
*''Carbonic anhydrase XIV'' | *''Carbonic anhydrase XIV'' | ||
| + | **[[4lu3]], [[5cjf]] – hCA14 + sulfonamide inhibitor<br /> | ||
**[[1rj5]] – mCA14 extracellular domain <br /> | **[[1rj5]] – mCA14 extracellular domain <br /> | ||
**[[1rj6]] – mCA14 extracellular domain + inhibitor<br /> | **[[1rj6]] – mCA14 extracellular domain + inhibitor<br /> | ||
| - | **[[4lu3]], [[5cjf]] – hCA14 + sulfonamide inhibitor<br /> | ||
*'''Other carbonic anhydrases''' | *'''Other carbonic anhydrases''' | ||
| Line 171: | Line 186: | ||
*'''β-carbonic anhydrase''' | *'''β-carbonic anhydrase''' | ||
| - | **[[ | + | **[[1ekj]] – CA – pea<br /> |
**[[3eyx]] – CA residues 14-221 – yeast<br /> | **[[3eyx]] – CA residues 14-221 – yeast<br /> | ||
| - | **[[2esf]], [[1t75]], [[1i6o]], [[1i6p]], [[4znz]] – CA2 – ''Escherichia coli''<br /> | + | **[[6jqc]], [[6jqe]], [[7coi]], [[7coj]], [[7cxw]], [[7cxx]], [[7cxy]] – AfCA – ''Aspergillus fumigatus''<br /> |
| + | **[[6jqd]], [[6lac]], [[6lai]] – AfCA (mutant)<br /> | ||
| + | **[[6y04]] – CA – ''Trichomonas vaginalis''<br /> | ||
| + | **[[2esf]], [[1t75]], [[1i6o]], [[1i6p]], [[4znz]], [[7sev]] – CA2 – ''Escherichia coli''<br /> | ||
**[[2fgy]] – CA (mutant) – ''Halothiobacillus neapolitanus''<br /> | **[[2fgy]] – CA (mutant) – ''Halothiobacillus neapolitanus''<br /> | ||
**[[2a5v]], [[1ym3]], [[4yf4]], [[4yf5]], [[4yf6]] – CA – ''Mycobacterium tuberculosis''<br /> | **[[2a5v]], [[1ym3]], [[4yf4]], [[4yf5]], [[4yf6]] – CA – ''Mycobacterium tuberculosis''<br /> | ||
**[[1g5c]] – CA – ''Methanobacterkium thermoautotrophicum''<br /> | **[[1g5c]] – CA – ''Methanobacterkium thermoautotrophicum''<br /> | ||
| - | **[[1ekj]] – CA – pea<br /> | ||
**[[1ddz]] – CA – ''Porphyridium purpureum''<br /> | **[[1ddz]] – CA – ''Porphyridium purpureum''<br /> | ||
**[[3mf3]] – HiCA (Co) – ''Haemophilus influenza''<br /> | **[[3mf3]] – HiCA (Co) – ''Haemophilus influenza''<br /> | ||
| Line 188: | Line 205: | ||
**[[6d2o]], [[2d2m]] – PaCA + imidazole derivative<br /> | **[[6d2o]], [[2d2m]] – PaCA + imidazole derivative<br /> | ||
**[[6d2n]] – PaCA + sulfonamide<br /> | **[[6d2n]] – PaCA + sulfonamide<br /> | ||
| - | **[[6d2j]] – PaCA + SCN<br /> | + | **[[6d2j]], [[6d2m]] – PaCA + SCN<br /> |
**[[5cxk]] – CA – ''Vibrio cholerae''<br /> | **[[5cxk]] – CA – ''Vibrio cholerae''<br /> | ||
**[[5swc]] – CA – ''Synechocystis''<br /> | **[[5swc]] – CA – ''Synechocystis''<br /> | ||
| + | **[[1qy1]], [[3qy1]] – CA – ''Salmonella enterica''<br /> | ||
| + | **[[6yjn]], [[6yl7]] – CA – ''Burkholderia pseudomallei''<br /> | ||
*'''γ-carbonic anhydrase''' | *'''γ-carbonic anhydrase''' | ||
| Line 200: | Line 219: | ||
**[[1v67]], [[1v3w]] - PhCA + bicarbonate<br /> | **[[1v67]], [[1v3w]] - PhCA + bicarbonate<br /> | ||
**[[3kwc]], [[3kwd]], [[3kwe]] – CA – ''Thermosynechococcus elongatus''<br /> | **[[3kwc]], [[3kwd]], [[3kwe]] – CA – ''Thermosynechococcus elongatus''<br /> | ||
| + | |||
| + | *'''ι-carbonic anhydrase''' | ||
| + | |||
| + | **[[7c5v]], [[7c5w]], [[7c5x]], [[7c5y]] – CA – ''Bigelowiella natans''<br /> | ||
| + | |||
| + | *'''Cd-specific carbonic anhydrase''' | ||
| + | |||
**[[3r1w]] – CA – unidentified<br /> | **[[3r1w]] – CA – unidentified<br /> | ||
**[[3bob]], [[3boe]], [[3boh]] – TwCA (Cd) domain 2 – ''Thalassiosira weissflogii''<br /> | **[[3bob]], [[3boe]], [[3boh]] – TwCA (Cd) domain 2 – ''Thalassiosira weissflogii''<br /> | ||
**[[3boj]] - TwCA domain 1<br /> | **[[3boj]] - TwCA domain 1<br /> | ||
**[[3boc]] - TwCA domain 2<br /> | **[[3boc]] - TwCA domain 2<br /> | ||
| - | **[[3uk8]] - TwCA domain 3<br /> | + | **[[3uk8]], [[7bez]], [[7bf0]] - TwCA domain 3<br /> |
**[[1kop]], [[1koq]] – CA – ''Neisseria gonorrheae'' | **[[1kop]], [[1koq]] – CA – ''Neisseria gonorrheae'' | ||
}} | }} | ||
Current revision
Updated on 13-November-2022 - For a general description of the protein see Carbonic anhydrase
