6rgi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6rgi is ON HOLD Authors: Engilberge, S., Rennie, M.L., Crowley, P.B. Description: Partially unfolded cytochrome c in complex with sulfonatocalix[6]...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Partially unfolded cytochrome c in complex with sulfonatocalix[6]arene== | |
| + | <StructureSection load='6rgi' size='340' side='right'caption='[[6rgi]], [[Resolution|resolution]] 2.64Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6rgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RGI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rgi OCA], [https://pdbe.org/6rgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rgi RCSB], [https://www.ebi.ac.uk/pdbsum/6rgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rgi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CYC1_YEAST CYC1_YEAST] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Supramolecular receptors such as water-soluble calixarenes are in development as 'molecular glues' for protein assembly. Here, we obtained cocrystals of sulfonato-calix[6]arene (sclx6 ) and yeast cytochrome c (cytc) in the presence of imidazole. A crystal structure at 2.65 A resolution reveals major structural rearrangement and disorder in imidazole-bound cytc. The largest protein-calixarene interface involves 440 A(2) of the protein surface with key contacts at Arg13, Lys73, and Lys79. These lysines participate in alkaline transitions of cytc and are part of Omega-loop D, which is substantially restructured in the complex with sclx6 . The structural modification also includes Omega-loop C, which is disordered (residues 41-55 inclusive). These results suggest the possibility of using supramolecular scaffolds to trap partially disordered proteins. | ||
| - | + | Calixarene capture of partially unfolded cytochrome c.,Engilberge S, Rennie ML, Crowley PB FEBS Lett. 2019 Jun 29. doi: 10.1002/1873-3468.13512. PMID:31254353<ref>PMID:31254353</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6rgi" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: Engilberge | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae S288C]] | ||
| + | [[Category: Crowley PB]] | ||
| + | [[Category: Engilberge S]] | ||
| + | [[Category: Rennie ML]] | ||
Current revision
Partially unfolded cytochrome c in complex with sulfonatocalix[6]arene
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