6n1t

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Current revision (06:43, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6n1t' size='340' side='right'caption='[[6n1t]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6n1t' size='340' side='right'caption='[[6n1t]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6n1t]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N1T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6n1t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N1T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eil|4eil]], [[6aog|6aog]], [[6aoh|6aoh]], [[6aoi|6aoi]], [[6n1s|6n1s]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOD:5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine'>BOD</scene>, <scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1t OCA], [http://pdbe.org/6n1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n1t RCSB], [http://www.ebi.ac.uk/pdbsum/6n1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n1t OCA], [https://pdbe.org/6n1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n1t RCSB], [https://www.ebi.ac.uk/pdbsum/6n1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n1t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
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[https://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6n1t" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6n1t" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Toxgo]]
 
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[[Category: Barks, J]]
 
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[[Category: Brockman, A]]
 
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[[Category: Gould, J]]
 
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[[Category: Hopper, A T]]
 
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[[Category: Radke, J B]]
 
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[[Category: Sibley, L D]]
 
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[[Category: Thomas, S B]]
 
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[[Category: Wise, A]]
 
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[[Category: Zou, Y]]
 
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[[Category: Dhfr]]
 
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[[Category: Oxidoreductase]]
 
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
 
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Barks J]]
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[[Category: Brockman A]]
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[[Category: Gould J]]
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[[Category: Hopper AT]]
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[[Category: Radke JB]]
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[[Category: Sibley LD]]
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[[Category: Thomas SB]]
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[[Category: Wise A]]
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[[Category: Zou Y]]

Current revision

Toxoplasma gondii TS-DHFR in complex with selective inhibitor 3

PDB ID 6n1t

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OCA

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