4qy2

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<StructureSection load='4qy2' size='340' side='right'caption='[[4qy2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4qy2' size='340' side='right'caption='[[4qy2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qy2]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QY2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qy2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QY2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.399&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qy0|4qy0]], [[4qy1|4qy1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qy2 OCA], [http://pdbe.org/4qy2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qy2 RCSB], [http://www.ebi.ac.uk/pdbsum/4qy2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qy2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qy2 OCA], [https://pdbe.org/4qy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qy2 RCSB], [https://www.ebi.ac.uk/pdbsum/4qy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qy2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A059T4A1_9INFA A0A059T4A1_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046810]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Hemagglutinin|Hemagglutinin]]
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Influenza A virus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bi, Y]]
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[[Category: Bi Y]]
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[[Category: Gao, G F]]
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[[Category: Gao GF]]
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[[Category: Huang, C]]
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[[Category: Huang C]]
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[[Category: Li, X]]
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[[Category: Li X]]
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[[Category: Liu, J]]
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[[Category: Liu J]]
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[[Category: Qi, J]]
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[[Category: Qi J]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Shu, Y]]
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[[Category: Shu Y]]
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[[Category: Sun, H]]
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[[Category: Sun H]]
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[[Category: Wang, F]]
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[[Category: Wang F]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Wu, Y]]
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[[Category: Wu Y]]
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[[Category: Yan, J]]
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[[Category: Yan J]]
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[[Category: Zhang, W]]
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[[Category: Zhang W]]
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[[Category: Zhou, J]]
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[[Category: Zhou J]]
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[[Category: Memebrane fusion]]
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[[Category: Receptor binding]]
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[[Category: Viral protein]]
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Current revision

Structure of H10 from human-infecting H10N8 virus in complex with human receptor analog

PDB ID 4qy2

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