4qlo

<table><tr><td colspan='2'>[[4qlo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staat Staat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QLO FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AZ30_00060, metX, SACOL0012, USA300HOU_0012 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=451516 STAAT])</td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_O-acetyltransferase Homoserine O-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.31 2.3.1.31] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qlo OCA], [http://pdbe.org/4qlo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qlo RCSB], [http://www.ebi.ac.uk/pdbsum/4qlo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qlo ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Homoserine O-acetyltransferase (HTA) catalyzes the formation of L-O-acetyl-homoserine from L-homoserine through the transfer of an acetyl group from acetyl-CoA. This is the first committed step required for the biosynthesis of methionine in many fungi, Gram-positive bacteria and some Gram-negative bacteria. The structure of HTA from Staphylococcus aureus (SaHTA) has been determined to a resolution of 2.45 A. The structure belongs to the alpha/beta-hydrolase superfamily, consisting of two distinct domains: a core alpha/beta-domain containing the catalytic site and a lid domain assembled into a helical bundle. The active site consists of a classical catalytic triad located at the end of a deep tunnel. Structure analysis revealed some important differences for SaHTA compared with the few known structures of HTA.

Structure of homoserine O-acetyltransferase from Staphylococcus aureus: the first Gram-positive ortholog structure.,Thangavelu B, Pavlovsky AG, Viola R Acta Crystallogr F Struct Biol Commun. 2014 Oct;70(Pt 10):1340-5. doi:, 10.1107/S2053230X14018664. Epub 2014 Sep 25. PMID:25286936<ref>PMID:25286936</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4qlo" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Homoserine O-acetyltransferase]]

[[Category: Staat]]

[[Category: Pavlovsky, A G]]

[[Category: Thangavelu, B]]

[[Category: Viola, R E]]

[[Category: Transferase]]