This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4q6z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:44, 1 March 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='4q6z' size='340' side='right'caption='[[4q6z]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4q6z' size='340' side='right'caption='[[4q6z]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4q6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecout Ecout]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6Z FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4q6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_UTI89 Escherichia coli UTI89]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6Z FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q6v|4q6v]], [[4q6l|4q6l]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpoB, UTI89_C1233 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=364106 ECOUT])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6z OCA], [https://pdbe.org/4q6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6z RCSB], [https://www.ebi.ac.uk/pdbsum/4q6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6z ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6z OCA], [http://pdbe.org/4q6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q6z RCSB], [http://www.ebi.ac.uk/pdbsum/4q6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6z ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/Q1RD49_ECOUT Q1RD49_ECOUT]] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity).[HAMAP-Rule:MF_01889]
+
[https://www.uniprot.org/uniprot/Q1RD49_ECOUT Q1RD49_ECOUT] Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity).[HAMAP-Rule:MF_01889]
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
In bacteria, the synthesis of the protective peptidoglycan sacculus is a dynamic process that is tightly regulated at multiple levels. Recently, the lipoprotein co-factor LpoB has been found essential for the in-vivo function of the major peptidoglycan synthase PBP1b in Enterobacteriaceae. Herein, we reveal the crystal structures of Salmonella enterica and Escherichia coli LpoB. The LpoB protein can be modeled as a ball and tether, consisting of a disordered N-terminal region, followed by a compact globular C-terminal domain. Taken together, our structural data allows us to propose a revised model for LpoB mediated regulation of peptidoglycan synthesis.
+
-
 
+
-
Structural insights into the lipoprotein outer-membrane regulator of penicillin-binding protein 1B.,King DT, Lameignere E, Strynadka NC J Biol Chem. 2014 May 7. pii: jbc.M114.565879. PMID:24808177<ref>PMID:24808177</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4q6z" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Ecout]]
+
[[Category: Escherichia coli UTI89]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: King, D T]]
+
[[Category: King DT]]
-
[[Category: Strynadka, N C.J]]
+
[[Category: Strynadka NCJ]]
-
[[Category: Activator of pbp1b]]
+
-
[[Category: Lipidation]]
+
-
[[Category: Lipoprotein]]
+
-
[[Category: Mixed alpha-beta]]
+
-
[[Category: Outer-membrane]]
+
-
[[Category: Pbp1b]]
+
-
[[Category: Protein binding]]
+

Current revision

LpoB C-terminal domain from Escherichia coli

PDB ID 4q6z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4q6z"
Personal tools