4qpf
From Proteopedia
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<StructureSection load='4qpf' size='340' side='right'caption='[[4qpf]], [[Resolution|resolution]] 1.59Å' scene=''> | <StructureSection load='4qpf' size='340' side='right'caption='[[4qpf]], [[Resolution|resolution]] 1.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPF FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [https://pdbe.org/4qpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [https://www.ebi.ac.uk/pdbsum/4qpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpf ProSAT]</span></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
==See Also== | ==See Also== | ||
- | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | + | *[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Barnett | + | [[Category: Barnett BL]] |
- | [[Category: Duan | + | [[Category: Duan Z]] |
- | [[Category: Dunford | + | [[Category: Dunford JE]] |
- | [[Category: Ebetino | + | [[Category: Ebetino FH]] |
- | [[Category: Jeans | + | [[Category: Jeans G]] |
- | [[Category: Kwaasi | + | [[Category: Kwaasi AA]] |
- | [[Category: Lundy | + | [[Category: Lundy M]] |
- | [[Category: Mazur | + | [[Category: Mazur A]] |
- | [[Category: Russell | + | [[Category: Russell RGG]] |
- | [[Category: Triffitt | + | [[Category: Triffitt J]] |
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Current revision
New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
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Categories: Homo sapiens | Large Structures | Barnett BL | Duan Z | Dunford JE | Ebetino FH | Jeans G | Kwaasi AA | Lundy M | Mazur A | Russell RGG | Triffitt J