Catabolite control protein
From Proteopedia
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'''Catabolite control protein''' (CcpA) or '''glucose-resistant amylase regulator''' is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref> | '''Catabolite control protein''' (CcpA) or '''glucose-resistant amylase regulator''' is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.<ref>PMID:16321938</ref> | ||
| + | *'''CcpC''' Regulates the transcription of genes belonging to the TCA cycle<ref>PMID:34645869</ref> . | ||
| + | *'''CcpE''' Regulates the transcription of genes belonging to the TCA cycle in ''Staphylococcus aureus''<ref>PMID:25193664</ref> . | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of catabolite control protein== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *CcpA | ||
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| - | **[[2jcg]], [[2hsg]] - BmCcpA – ''Bacillus megaterium'' <br /> | ||
| - | **[[2o20]] - CcpA (mutant) – ''Streptococcus lactis'' <br /> | ||
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| - | *CcpA binary complex | ||
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| - | **[[2oen]] - BmCcpA + phosphocarrier protein HPr <br /> | ||
| - | **[[2fep]] - BsCcpA + phosphocarrier protein HPr – ''Bacillus subtilis''<br /> | ||
| - | **[[4rk6]] - WpCcpA + glucose – ''Weissella paramesenteroides'' <br /> | ||
| - | **[[4rk7]] - WpCcpA + sucrose <br /> | ||
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| - | *CcpA ternary complex | ||
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| - | **[[1rzr]] – BmCcpA + phosphocarrier protein HPr + DNA <br /> | ||
| - | **[[2nzu]] - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate <br /> | ||
| - | **[[2nzv]] - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate <br /> | ||
| - | **[[1zvv]] – BsCcpA + catabolite repression Crh + DNA <br /> | ||
| - | **[[3oqm]], [[3oqn]], [[3oqo]] - BsCcpA + phosphocarrier protein HPr + DNA<br /> | ||
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| - | *CcpC | ||
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| - | **[[5z72]] - CcpC + citrate – ''Bacillus velezensis''<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Iyer R, Baliga NS, Camilli A. Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae. J Bacteriol. 2005 Dec;187(24):8340-9. PMID:16321938 doi:http://dx.doi.org/10.1128/JB.187.24.8340-8349.2005
- ↑ Liu W, Chen J, Jin L, Liu ZY, Lu M, Jiang G, Yang Q, Quan C, Nam KH, Xu Y. Functional and structural analysis of catabolite control protein C that responds to citrate. Sci Rep. 2021 Oct 13;11(1):20285. PMID:34645869 doi:10.1038/s41598-021-99552-x
- ↑ Hartmann T, Baronian G, Nippe N, Voss M, Schulthess B, Wolz C, Eisenbeis J, Schmidt-Hohagen K, Gaupp R, Sunderkötter C, Beisswenger C, Bals R, Somerville GA, Herrmann M, Molle V, Bischoff M. The catabolite control protein E (CcpE) affects virulence determinant production and pathogenesis of Staphylococcus aureus. J Biol Chem. 2014 Oct 24;289(43):29701-11. PMID:25193664 doi:10.1074/jbc.M114.584979
- ↑ Deutscher J, Reizer J, Fischer C, Galinier A, Saier MH Jr, Steinmetz M. Loss of protein kinase-catalyzed phosphorylation of HPr, a phosphocarrier protein of the phosphotransferase system, by mutation of the ptsH gene confers catabolite repression resistance to several catabolic genes of Bacillus subtilis. J Bacteriol. 1994 Jun;176(11):3336-44. PMID:8195089
- ↑ Fujita Y, Miwa Y, Galinier A, Deutscher J. Specific recognition of the Bacillus subtilis gnt cis-acting catabolite-responsive element by a protein complex formed between CcpA and seryl-phosphorylated HPr. Mol Microbiol. 1995 Sep;17(5):953-60. PMID:8596444
