Image:Homocysteine metabolic pathway.png
From Proteopedia
Size of this preview: 657 × 600 pixels
Full resolution (998 × 911 pixel, file size: 296 KB, MIME type: image/png)
(Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate red) |
|||
| (One intermediate revision not shown.) | |||
| Line 2: | Line 2: | ||
Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate reductase (Mthfr). The methyl group is donated to Hcy and in the presence of methionine synthase (Mtr), and B12 is converted to methionine. Methionine is used in many methyl transfer reactions. When the diet is replete with methionine, Hcy is converted, via the transsulfuration pathway, to cystathionine by cystathionine β-synthase (Cbs) and then converted to cysteine via the action of cystathionase (Cth, Cse) in the presence of B6. Cysteine is converted to several beneficial downstream products. | Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate reductase (Mthfr). The methyl group is donated to Hcy and in the presence of methionine synthase (Mtr), and B12 is converted to methionine. Methionine is used in many methyl transfer reactions. When the diet is replete with methionine, Hcy is converted, via the transsulfuration pathway, to cystathionine by cystathionine β-synthase (Cbs) and then converted to cysteine via the action of cystathionase (Cth, Cse) in the presence of B6. Cysteine is converted to several beneficial downstream products. | ||
== Licensing == | == Licensing == | ||
| - | + | Cui X, Navneet S, Wang J, Roon P, Chen W, Xian M, Smith SB. Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice. Invest Ophthalmol Vis Sci. 2017 Apr;58(4):1954-1963. doi: 10.1167/iovs.16-21247. PubMed PMID: 28384716; PubMed Central PMCID: PMC5381329. | |
Current revision
Beskrivning
Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate reductase (Mthfr). The methyl group is donated to Hcy and in the presence of methionine synthase (Mtr), and B12 is converted to methionine. Methionine is used in many methyl transfer reactions. When the diet is replete with methionine, Hcy is converted, via the transsulfuration pathway, to cystathionine by cystathionine β-synthase (Cbs) and then converted to cysteine via the action of cystathionase (Cth, Cse) in the presence of B6. Cysteine is converted to several beneficial downstream products.
Licensing
Cui X, Navneet S, Wang J, Roon P, Chen W, Xian M, Smith SB. Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice. Invest Ophthalmol Vis Sci. 2017 Apr;58(4):1954-1963. doi: 10.1167/iovs.16-21247. PubMed PMID: 28384716; PubMed Central PMCID: PMC5381329.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | User | Dimensions | File size | Comment | |
|---|---|---|---|---|---|
| (current) | 19:48, 28 April 2019 | Jan Hamalcik (Talk | contribs) | 998×911 | 296 KB | Homocysteine metabolic pathway. Homocysteine sits at the intersection of the remethylation and transsulfuration pathways. In the remethylation pathway, THF is converted to N5,N10-methylene tetrahydrofolate and then to MTHF by methylenetetrahydrofolate red |
- Edit this file using an external application
See the setup instructions for more information.
Links
The following pages link to this file:
